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2. 发明申请

US20100260677A1 METHODS AND SYSTEMS FOR TREATMENT AND/OR DIAGNOSIS 审中-公开
标题翻译：用于治疗和/或诊断的方法和系统
公开(公告)号：US20100260677A1
公开(公告)日：2010-10-14
申请号：US12716217
申请日：2010-03-02
申请人： Sangeeta N. Bhatia , Geoffrey A. von Maltzahn
发明人： Sangeeta N. Bhatia , Geoffrey A. von Maltzahn
IPC分类号： A61K9/14 , A61K49/00
CPC分类号： C07K7/02 , A61K41/0052 , A61K47/62 , A61K47/6923 , C07K7/08
摘要： The invention relates to methods and systems that can be used for treatment and/or diagnosis. In one aspect, the present invention involves systems and methods for activating a biological cascade in a subject, and administering, to the subject, a composition or a component comprising an agent able to bind a product of a biological cascade or otherwise interact with the biological cascade. The biological cascade may be, for example, a coagulation cascade, a complement cascade, an inflammation cascade, or the like. In some cases, the concentration of a protein, the metabolic demand for a substrate, or the like may be increased as a result of activation of the biological cascade. As a specific non-limiting example, in one set of embodiments, the biological cascade may be a coagulation cascade and the composition administered to the subject may include a fibrin-binding peptide and an antitumor species. By activating the biological cascade, e.g., with an activation composition or by applying energy, coagulation may be induced in a tumor, which the antitumor species may associate with due to an increase in fibrin caused by the coagulation cascade. In addition, in certain aspects, the present invention involves systems and methods for changing tissue from a first state to a second state, for instance, with a first composition comprising nanoparticles. The second composition may be more responsive to the tissue in the second state than in the first state in some cases. In still other aspects, the present invention is generally directed to systems and methods for making such compositions, systems and methods for promoting such compositions, kits involving such compositions, or the like.
摘要翻译：本发明涉及可用于治疗和/或诊断的方法和系统。在一个方面，本发明涉及用于激活受试者中的生物级联的系统和方法，以及向受试者施用组合物或组分，所述组合物或组分包含能够结合生物级联产物或以其它方式与生物级联相互作用的试剂级联。生物级联可以是例如凝血级联，补体级联，炎症级联等。在某些情况下，由于生物级联的活化，蛋白质的浓度，对底物的代谢需求等可能会增加。作为具体的非限制性实例，在一组实施方案中，生物级联可以是凝血级联，并且施用于受试者的组合物可以包括纤维蛋白结合肽和抗肿瘤物质。通过活化生物级联，例如通过活化组合物或通过施加能量，可以在肿瘤中诱导凝血，抗肿瘤物质可能由于凝血级联引起的纤维蛋白增加而与之结合。此外，在某些方面，本发明涉及用于将组织从第一状态改变到第二状态的系统和方法，例如，包含纳米颗粒的第一组合物。在某些情况下，第二组合物可能对第二状态中的组织比对第一状态更有反应。在其它方面，本发明一般涉及用于制备这种组合物的系统和方法，用于促进这种组合物的系统和方法，涉及这种组合物的试剂盒等。

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