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    • 2. 发明授权
    • Inhibition of gene expression using RNA interfering agents
    • 使用RNA干扰剂抑制基因表达
    • US07696179B2
    • 2010-04-13
    • US10533621
    • 2003-10-29
    • Judy LiebermanManjunath NarasimhaswamyErwei SongSang-Kyung LeePremlata Shankar
    • Judy LiebermanManjunath NarasimhaswamyErwei SongSang-Kyung LeePremlata Shankar
    • A01N63/00A61K48/00
    • C12N15/1138A61K38/00A61M1/14A61M1/16A61M1/1609A61M1/1617A61M1/3406A61M1/3609A61M1/3612A61M2202/0498A61M2205/15A61M2205/33A61M2205/3317A61M2205/3324A61M2205/50A61M2205/52C12N15/1132C12N2310/111C12N2310/14C12N2310/53Y02A50/465
    • The present invention is based, at least in part, on the discovery of compositions and methods for the treatment and prevention of infectious diseases or disorders, e.g., HIV infection, AIDS, and AIDS-related diseases. In particular, the present invention pertains to methods of modulating cellular gene expression or protein activity, e.g., CCR5, gene expression or protein activity and/or gene expression or protein activity of a gene or sequence of an infectious agent, in order to treat or prevent infectious diseases or disorders, HIV infection, AIDS, or an AIDS-related disease or disorder. In one embodiment the combination of an RNA interfering agent targeting a cellular gene in combination with an RNA interfering agent targeting a gene or sequence of an infectious agent results in prolonged prevention of infection by an infectious agent. The present invention is based on the identification of novel RNA interference agents, e.g., siRNA molecules, which target cellular genes, e.g., chemokine receptors, e.g., the CCR5 gene, and result in inhibition of target gene expression on target gene expressing cells, thereby inhibiting entry of infectious agents, e,g., HIV infection into target cells, prevention infection, and/or suppressing replication in established infection.
    • 本发明至少部分地基于发现用于治疗和预防感染性疾病或病症的组合物和方法,例如HIV感染,AIDS和AIDS相关疾病。 特别地,本发明涉及调节细胞基因表达或蛋白质活性的方法,例如CCR5,基因表达或蛋白质活性和/或感染因子的基因或序列的基因表达或蛋白质活性,以便治疗或 预防传染病或疾病,艾滋病毒感染,艾滋病或艾滋病相关疾病或病症。 在一个实施方案中,靶向细胞基因的RNA干扰剂与靶向感染因子的基因或序列的RNA干扰剂的组合导致长期预防感染性感染的感染。 本发明基于鉴定靶向细胞基因(例如趋化因子受体,例如CCR5基因)的新型RNA干扰剂,例如siRNA分子,并导致靶基因表达细胞的靶基因表达的抑制,从而 抑制感染因子的侵入,例如艾滋病毒感染进入靶细胞,预防感染和/或抑制确定的感染中的复制。
    • 3. 发明申请
    • APPARATUS AND METHOD FOR RENDERING OBJECT IN 3D GRAPHIC TERMINAL
    • 3D图形终端渲染对象的设备和方法
    • US20120032951A1
    • 2012-02-09
    • US13197545
    • 2011-08-03
    • Sang-Kyung LeeKwang-Cheol ChoiHyung-Jin Bae
    • Sang-Kyung LeeKwang-Cheol ChoiHyung-Jin Bae
    • G06T15/00
    • H04N13/275
    • A method for rendering an object in a 3D graphic terminal includes constructing camera coordinates, based on vertex information of objects existing in a 3D space, and selecting one object in a left frustum and a right frustum, based on the constructed camera coordinates, wherein the left frustum is defined centered on a left virtual camera viewpoint, and the right frustum is defined centered on a right virtual camera viewpoint. The method further includes determining a binocular disparity by projecting vertexes of the selected object in the left frustum and the right frustum, and adjusting frustum parameters of the left virtual camera and the right virtual camera when the determined binocular disparity is greater than an allowable binocular disparity.
    • 一种用于在3D图形终端中渲染对象的方法包括:基于所建立的相机坐标,基于存在于3D空间中的对象的顶点信息来构造相机坐标,以及选择左平截头体和右平截头体中的一个对象,其中 左平截头体被定义为以左虚拟摄像机视点为中心,并且右平截头体被定义为以右虚拟摄像机视点为中心。 该方法还包括通过将所选择的对象的顶点投影在左平截头体和右平截头体中来确定双目视差,并且当确定的双目视差大于允许的双目视差时调整左虚拟照相机和右虚拟照相机的平截头体参数 。
    • 7. 发明授权
    • Method for crystallizing a silicon substrate
    • 硅衬底结晶方法
    • US09087697B2
    • 2015-07-21
    • US13890476
    • 2013-05-09
    • Sung-Ho KimMin-Hwan ChoiMin-Ji BaekSang-Kyung LeeSang-Ho JeonJong-Moo Huh
    • Sung-Ho KimMin-Hwan ChoiMin-Ji BaekSang-Kyung LeeSang-Ho JeonJong-Moo Huh
    • H01L21/02H01L21/66
    • H01L21/02686H01L21/02532H01L22/12H01L22/20
    • A method for crystallizing a silicon substrate includes manufacturing a crystallized silicon test substrate that is crystallized by scanning excimer laser annealing beams with different energy densities on respective areas of an amorphous silicon test substrate, irradiating a surface of the crystallized silicon test substrate using a light source, and measuring reflectivity corresponding to the respective areas of the crystallized silicon test substrate in a visible light wavelength range, extracting average reflectivities of the respective areas of the crystallized silicon test substrate in wavelength ranges corresponding to respective colors, calculating an optimum energy density (OPED) index per energy density by using a value acquired by subtracting average reflectivity of red-based colors from average reflectivity of blue-based colors, selecting an optimal energy density, and crystallizing an amorphous silicon substrate using the optimal energy density.
    • 一种硅衬底的结晶方法包括:制造结晶硅测试衬底,其通过在非晶硅测试衬底的各个区域上扫描具有不同能量密度的准分子激光退火光束而被结晶,使用光源照射结晶硅测试衬底的表面 ,并且在可见光波长范围内测量对应于结晶硅测试衬底的各个区域的反射率,提取结晶硅测试衬底的各个区域的平均反射率,其对应于各种颜色的波长范围,计算最佳能量密度(OPED )通过使用通过从基于蓝色的颜色的平均反射率减去红色颜色的平均反射率而获得的值,选择最佳能量密度,并使用最佳能量密度结晶非晶硅衬底而获得的值。