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    • 6. 发明授权
    • Apparatus and method for testing socket
    • 插座测试装置及方法
    • US06792376B2
    • 2004-09-14
    • US10353217
    • 2003-01-27
    • Ill Young LeeDong Myun ByonTae Won KangSei Woong Kim
    • Ill Young LeeDong Myun ByonTae Won KangSei Woong Kim
    • G01R3100
    • G01R31/2808G01R35/005
    • An apparatus and a method for testing a socket are disclosed. The resistance values of the contactor pins of the socket can be precisely measured, and the measurement is made automatic so as to decrease the expense and manpower. The method includes the following steps. That is, a calibration PCB is formed into a closed circuit, and all the resistance values forming a closed circuit loop for respective channels are extracted and stored (first step). A socket-installed PCB is formed into a closed circuit, and all resistance values forming a closed circuit loop for respective channels are extracted and stored (second step). Differences between the resistance values of the respective channels of the calibration PCB and the resistance values of the respective channels of the socket-installed PCB are calculated (third step). The differences thus calculated are displayed to a screen for the respective channels (fourth step).
    • 公开了一种用于测试插座的装置和方法。 可以精确测量插座的接触器销的电阻值,自动进行测量,以降低成本和人力。 该方法包括以下步骤。 也就是说,校准PCB被形成为闭合电路,并且提取并存储形成用于各个通道的闭路回路的所有电阻值(第一步)。 将插座安装的PCB形成为闭合电路,并且提取并存储形成用于相应通道的闭路回路的所有电阻值(第二步骤)。 计算校准PCB的各个通道的电阻值与插座安装的PCB的各个通道的电阻值之间的差异(第三步)。 将如此计算的差异显示给相应通道的屏幕(第四步骤)。
    • 7. 发明授权
    • Process for preparing simvastatin
    • 辛伐他汀的制备方法
    • US06833461B2
    • 2004-12-21
    • US10468852
    • 2003-08-25
    • Chung Il HongJung Woo KimHee Jong ShinTae Won KangDong Ock Cho
    • Chung Il HongJung Woo KimHee Jong ShinTae Won KangDong Ock Cho
    • C07D30930
    • C07D309/30Y02P20/55
    • The present invention relates to an improved process for preparing simvastatin and more particularly, the improved process for preparing simvastatin expressed by formula 1 with high yield and high purity by performing the following sequential processes comprising: (i) hydrolysis of lovastatin as starting material with potassium t-butoxide in an organic solvent and small amount of water under a mild reaction condition, followed by lactonization of the obtained solid intermediate with preventing from formation of by-products; (ii) protection of an alcohol group with t-butyldimethylsilyl group which can be easily removed with concentrated hydrochloric acid without the formation of by-products; (iii) acylation of the obtained protected intermediate with acyloxytriphenyl phosphonium salt as an acylating agent under a mild reaction condition; and (iv) removal of the silyl protective group with a concentrated hydrochloric acid. The present invention is to provide the improved process of preparing simvastatin expressed by formula 1 environmentally sound, economically efficient, and industrially useful.
    • 本发明涉及一种制备辛伐他汀的改进方法,更具体地说,涉及通过进行以下顺序方法制备具有高产率和高纯度的式1所表达的辛伐他汀的改进方法,包括:(i)将洛伐他汀作为原料与钾 叔丁醇在有机溶剂和少量水中,在温和的反应条件下,然后将所得固体中间体内酯化,防止副产物的形成; (ii)用叔丁基二甲基甲硅烷基保护醇基,其可以用浓盐酸容易地除去而不形成副产物; (iii)在温和的反应条件下用酰氧基三苯基鏻盐作为酰化剂酰化所得保护的中间体; 和(iv)用浓盐酸除去甲硅烷基保护基。 本发明提供了由式1表达的辛伐他汀的改进方法,其在环境无害,经济有效和工业上有用。