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1. 发明申请

US20050089884A1 Genes for synthesis of FR-008 polyketides 失效
标题翻译：用于合成FR-008聚酮化合物的基因
公开(公告)号：US20050089884A1
公开(公告)日：2005-04-28
申请号：US10819386
申请日：2004-04-06
申请人： Sang Lee , Zixin Deng , Shi Chen , Ki Jeong , Xiufen Zhou
发明人： Sang Lee , Zixin Deng , Shi Chen , Ki Jeong , Xiufen Zhou
IPC分类号： C12N15/09 , A61K31/335 , A61K31/35 , A61K31/7048 , A61P31/04 , C07D313/00 , C07D493/08 , C07H17/08 , C07H21/04 , C07K14/36 , C12N1/21 , C12N9/00 , C12N15/31 , C12N15/52 , C12P17/08 , C12P19/62 , C12Q1/68 , C12N9/10 , C12N15/74
CPC分类号： C12P19/62 , C07H21/04 , C07K14/36 , C12N15/52 , C12P17/08
摘要： The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
摘要翻译：本发明涉及参与由链霉菌属（Streptomyces sp。）生产的FR-008聚酮化合物的生物合成的全基因的碱基序列。 FR-008。该碱基序列包括编码酮解酶（KS），酰基转移酶（AT），酰基载体蛋白（ACP），酮还原酶（KR），脱水酶（DH）和烯酰还原酶（ER）结构域的基因，以及编码修饰酶的基因，作为ABC转运蛋白，细胞色素P450单加氧酶，铁氧还蛋白，硫酯酶，糖合成蛋白，FAD依赖性单加氧酶，4-氨基-4-脱氧激酶（ADC）合酶和ADC裂解酶。根据本发明的基因碱基序列可用于通过改变其部分来提高现有FR-008聚酮化合物的生产率或生产新的FR-008聚酮化合物。

2. 发明申请

US20050244856A1 Diagnostic method for cancer characterized in the detection of the deletion of G-CSF exon 3 失效
公开(公告)号：US20050244856A1
公开(公告)日：2005-11-03
申请号：US11058976
申请日：2005-02-16
申请人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
发明人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
IPC分类号： G01N33/53 , C07K14/535 , C07K16/00 , C07K16/24 , C12M1/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N37/00 , C07H21/04 , G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

3. 发明申请

US20050170416A1 Diagnostic method for cancer characterized in the detection of the deletion of G-CSF exon 3 审中-公开
公开(公告)号：US20050170416A1
公开(公告)日：2005-08-04
申请号：US11059192
申请日：2005-02-16
申请人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
发明人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
IPC分类号： G01N33/53 , C07K14/535 , C07K16/00 , C07K16/24 , C12M1/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N37/00 , C07H21/04 , G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

4. 发明申请

US20050266430A1 Diagnostic method for cancer characterized in the detection of the deletion of G-CSF exon 3 审中-公开
公开(公告)号：US20050266430A1
公开(公告)日：2005-12-01
申请号：US11059222
申请日：2005-02-16
申请人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
发明人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
IPC分类号： G01N33/53 , C07K14/535 , C07K16/00 , C07K16/24 , C12M1/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N37/00 , C07H21/04 , C12P21/06 , G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

5. 发明申请

US20050170417A1 Diagnostic method for cancer characterized in the detection of the deletion of G-CSF exon 3 审中-公开
公开(公告)号：US20050170417A1
公开(公告)日：2005-08-04
申请号：US11059268
申请日：2005-02-16
申请人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
发明人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
IPC分类号： G01N33/53 , C07K14/535 , C07K16/00 , C07K16/24 , C12M1/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N37/00 , C07H21/04 , G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

6. 发明申请

US20050158810A1 Diagnostic method for cancer characterized in the detection of the deletion of G-CSF exon 3 审中-公开
标题翻译：用于检测G-CSF外显子3缺失的癌症诊断方法
公开(公告)号：US20050158810A1
公开(公告)日：2005-07-21
申请号：US11059127
申请日：2005-02-16
申请人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
发明人： Sang Lee , Nae Yoo , So Yoo , Hyun Chung , Ki Keum , Won Yoo , Ki Jeong
IPC分类号： G01N33/53 , C07K14/535 , C07K16/00 , C07K16/24 , C12M1/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N37/00 , G01N33/574 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

7. 发明申请

US20060029947A1 Combinatorial protein library screening by periplasmic expression 审中-公开
标题翻译：组织蛋白质文库筛选周质表达
公开(公告)号：US20060029947A1
公开(公告)日：2006-02-09
申请号：US11084055
申请日：2005-03-18
申请人： George Georgiou , Ki Jeong , Brent Iverson
发明人： George Georgiou , Ki Jeong , Brent Iverson
IPC分类号： C40B40/02 , C12Q1/68 , G01N33/53 , C12P21/06 , C12N15/74
CPC分类号： C12N15/1086 , C07K2319/02 , C07K2319/03 , C07K2319/034 , C07K2319/21 , C12N15/1037 , C40B40/02 , G01N33/5082 , G01N33/56911 , G01N33/6803
摘要： The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides. In the technique, libraries of candidate binding proteins, such as antibody sequences, may be expressed in the periplasm of gram negative bacteria with at least one target ligand. In clones expressing recombinant polypeptides with affinity for the ligand, the ligand becomes bound and retained by the cell even after removal of the outer membrane, allowing the cell to be isolated from cells not expressing a binding polypeptide with affinity for the target ligand. The target ligand may be detected in numerous ways, including use of direct fluorescence or secondary antibodies that are fluorescently labeled, allowing use of efficient screening techniques such as fluorescence activated cell sorting (FACS). The approach is more rapid and robust than prior art methods and avoids problems associated with the outer surface-expression of ligand fusion proteins employed with phage display.
摘要翻译：本发明通过提供用于分离能够结合小分子和肽的结合蛋白的快速方法来克服现有技术的缺陷。在该技术中，候选结合蛋白（例如抗体序列）的文库可以用至少一种靶配体在革兰氏阴性细菌的周质中表达。在表达具有对配体具有亲和力的重组多肽的克隆中，甚至在去除外膜之后，配体也被细胞结合并保留，使细胞从不表达具有对靶配体的亲和力的结合多肽的细胞中分离。可以以多种方式检测靶配体，包括使用荧光标记的直接荧光或二次抗体，允许使用有效的筛选技术，例如荧光激活细胞分选（FACS）。该方法比现有技术方法更快速和鲁棒，并且避免与用噬菌体展示使用的配体融合蛋白的外表面表达相关的问题。

8. 发明申请

US20060227499A1 Liquid crystal display device 有权
标题翻译：液晶显示装置
公开(公告)号：US20060227499A1
公开(公告)日：2006-10-12
申请号：US11449782
申请日：2006-06-09
申请人： Ki Jeong , Do Kim
发明人： Ki Jeong , Do Kim
IPC分类号： G06F1/16 , G09G3/20
CPC分类号： G02F1/133308 , G02F2001/133317 , G02F2201/46
摘要： An LCD device includes a joining structure for coupling a liquid crystal display module (LCM) and a front case and/or a back case without screws. The LCD device includes an LCM having at least one receiving part or at least one slot, and a bracket having at least one pin, or at least one joining part for securely coupling LCM and a back or front system case.
摘要翻译： LCD装置包括用于将液晶显示模块（LCM）和前壳体和/或后壳没有螺钉连接的接合结构。 LCD装置包括具有至少一个接收部分或至少一个狭槽的LCM以及具有至少一个销或至少一个用于牢固地联接LCM的连接部分和后部或前部系统壳体的支架。

9. 发明申请

US20070085826A1 Method of and system for evaluating tactile sensations of car seat covers using artificial neural network 有权
标题翻译：使用人工神经网络评估汽车座椅套的触感的方法和系统
公开(公告)号：US20070085826A1
公开(公告)日：2007-04-19
申请号：US11302406
申请日：2005-12-12
申请人： Jung Noh , Ki Jeong , Joo Kim , Baek Park
发明人： Jung Noh , Ki Jeong , Joo Kim , Baek Park
IPC分类号： G09G5/08
CPC分类号： B60N2/58
摘要： Disclosed herein is a method of and system for evaluating tactile sensations of car seat covers using an artificial neural network, in which mechanical and thermal/physiological characteristics of the seat covers is measured with a measuring system, the physical quantity of the measured characteristics is acquired, and then the acquired physical quantity is converted into the amount of tactile qualities which a person feels using a statistical recursive model, thereby quantitatively evaluating tactile sensations of sticky, soft, elastic, coolness to the touch, and thermal and humid in case of car seat covers made of leather, and tactile sensations of soft, elastic, voluminous, smooth, coolness to the touch, and thermal and humid in case of car seat covers made of cloth, as well as quantitatively evaluating tactile sensations of sporty and high-class of the leather and cloths using an artificial neural network model.
摘要翻译：本发明公开了一种使用人造神经网络评估汽车座椅罩的触感的方法和系统，其中用测量系统测量座椅罩的机械和热/生理特性，获得测量特性的物理量，然后将获得的物理量转换为人们使用统计递归模型的触觉质量，从而定量评估粘性，柔软，弹性，凉爽触觉的触感，以及汽车情况下的热湿度由皮革制成的座椅套，以及柔软，弹性，体积大，光滑，凉爽触感的触觉，以及用布制成的汽车座椅套的热湿度，以及定量评估运动型和高级别的触觉感觉的皮革和布料使用人造神经网络模型。

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