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1. 发明申请

US20120220890A1 DETECTING AND TREATING NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：检测和治疗神经系统疾病
公开(公告)号：US20120220890A1
公开(公告)日：2012-08-30
申请号：US13468337
申请日：2012-05-10
申请人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
发明人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
IPC分类号： A61B5/0476 , A61M5/168 , A61N1/36
CPC分类号： A61B5/0478 , A61B5/4064 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B18/082 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B2018/00214 , A61B2018/00446 , A61B2018/00577 , A61B2018/1467 , A61N1/0529
摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
摘要翻译：映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其他治疗。在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经系统紊乱这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。

2. 发明申请

US20080312715A1 Detecting and Treating Nervous System Disorders 有权
标题翻译：检测和治疗神经系统疾病
公开(公告)号：US20080312715A1
公开(公告)日：2008-12-18
申请号：US12094704
申请日：2006-11-21
申请人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
发明人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
IPC分类号： A61N1/05 , A61B18/14
CPC分类号： A61B5/0478 , A61B5/4064 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B18/082 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B2018/00214 , A61B2018/00446 , A61B2018/00577 , A61B2018/1467 , A61N1/0529
摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
摘要翻译：映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其它治疗。在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经系统紊乱这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。

3. 发明申请

US20100121188A1 REDUCING CONTRAST AGENT-INDUCED TOXICITY 审中-公开
标题翻译：减少对比剂引起的毒性
公开(公告)号：US20100121188A1
公开(公告)日：2010-05-13
申请号：US12445062
申请日：2007-10-10
申请人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
发明人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
IPC分类号： A61B6/10 , A61M25/00 , A61M25/10
CPC分类号： A61K49/18 , A61B17/22031 , A61B2017/00876 , A61B2017/22035 , A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076
摘要： This document provides methods and materials that can be used to reduce or prevent contrast agent-induced toxicity. For example, devices for capturing contrast agents from blood are provided.
摘要翻译：本文档提供了可用于减少或预防造影剂诱导的毒性的方法和材料。例如，提供用于从血液捕获造影剂的装置。

4. 发明申请

US20110144411A1 SYSTEMS AND METHODS FOR MAGNETIC-ASSISTED THERAPEUTIC AGENT DELIVERY 有权
标题翻译：用于磁辅助治疗药物递送的系统和方法
公开(公告)号：US20110144411A1
公开(公告)日：2011-06-16
申请号：US12809197
申请日：2008-12-19
申请人： Gurpreet S. Sandhu , David R. Holmes, JR. , Robert D. Simari , Nicole P. Sandhu
发明人： Gurpreet S. Sandhu , David R. Holmes, JR. , Robert D. Simari , Nicole P. Sandhu
IPC分类号： A61M37/00 , A61N2/02
CPC分类号： A61M37/00 , A61K9/5094 , A61N2/002 , A61N2/06
摘要： Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.
摘要翻译：公开了向选定组织提供治疗剂磁力增强递送的系统和方法。系统和方法涉及使用载体装置和释放装置以及两个不同的磁场以将磁性颗粒移动到选定的组织中。磁性颗粒（和任何相关联的治疗剂）进入组织的移动可以通过磁性吸引力以及磁性排斥力来辅助。

5. 发明申请

US20090210050A1 Implantable Device For Promoting Repair Of A Body Lumen 审中-公开
标题翻译：用于促进身体内腔修复的植入式装置
公开(公告)号：US20090210050A1
公开(公告)日：2009-08-20
申请号：US12429803
申请日：2009-04-24
申请人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译：提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长细胞以有组织的模式。或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

6. 发明申请

US20130211537A1 MEDICAL DEVICES INCLUDING DUPLEX STAINLESS STEEL 审中-公开
标题翻译：包括双相不锈钢的医疗设备
公开(公告)号：US20130211537A1
公开(公告)日：2013-08-15
申请号：US13699477
申请日：2011-05-24
申请人： Gurpreet S. Sandhu , Robert D. Simari , David R. Holmes, JR. , Dan Dragomir-Daescu , Anthony P. Parakka
发明人： Gurpreet S. Sandhu , Robert D. Simari , David R. Holmes, JR. , Dan Dragomir-Daescu , Anthony P. Parakka
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/915 , A61F2230/0054 , A61L31/022 , A61L31/14
摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The endoprostheses comprise a tubular member capable of maintaining patency of a bodily vessel. The tubular member includes a duplex stainless steel (e.g., 2205 stainless steel), which may be magnetized.
摘要翻译：公开了医疗装置，例如内用假体，以及制造装置的方法。内用假体包括能够保持身体血管通畅的管状构件。管状构件包括可被磁化的双相不锈钢（例如2205不锈钢）。

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