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1. 发明授权

US4928687A CO.sub.2 diagnostic monitor 失效
标题翻译：二氧化碳诊断监测仪
公开(公告)号：US4928687A
公开(公告)日：1990-05-29
申请号：US255400
申请日：1988-10-11
申请人： Samsun Lampotang , Dietrich Gravenstein , Joachim S. Gravenstein , Nikolaus Gravenstein , Michael J. Banner
发明人： Samsun Lampotang , Dietrich Gravenstein , Joachim S. Gravenstein , Nikolaus Gravenstein , Michael J. Banner
IPC分类号： A61M16/04
CPC分类号： A61M16/0488 , A61M2016/0413
摘要： A diagnostic monitor checks the carbon dioxide (CO.sub.2) content of a gas exiting a patient during endotracheal or esophageal intubation. A plurality of composition portions substantially change color in response to exposure to the carbon dioxide. The composition portions change color in response to different times of exposure to carbon dioxide. A magnifying or condensing lens may be positioned on the monitor to enhance viewing of the color change. The monitor may advantageously be made as part of an intubation system through which the gases from a patient exit the patient. The differences in time of exposure needed to cause the color change may be accomplished by using semipermeable membranes having differing thicknesses, CO.sub.2 permeabilities, and/or surface areas with each membrane corresponding to a particular one of the composition portions.
摘要翻译：诊断监测器检查在气管插管或食管插管期间离开患者的气体的二氧化碳（CO2）含量。多个组合物部分基于暴露于二氧化碳而显着改变颜色。组合物部分响应于暴露于二氧化碳的不同时间而改变颜色。可以将放大或聚光透镜放置在监视器上以增强对颜色变化的观察。可以有利地将监测器制成为插管系统的一部分，来自患者的气体通过该插管系统离开患者。导致颜色变化所需的曝光时间差异可以通过使用具有不同厚度的半透膜，CO 2渗透性和/或表面积来实现，其中每个膜对应于组合物部分的特定一个。

2. 发明授权

US5156159A CO.sub.2 diagnostic monitor with rupturable container 失效
标题翻译：具有可破裂容器的二氧化碳诊断监视器
公开(公告)号：US5156159A
公开(公告)日：1992-10-20
申请号：US505689
申请日：1990-04-09
申请人： Samsun Lampotang , Joachim S. Gravenstein , Nikolaus Gravenstein , Michael J. Banner , Dietrich Gravenstein
发明人： Samsun Lampotang , Joachim S. Gravenstein , Nikolaus Gravenstein , Michael J. Banner , Dietrich Gravenstein
IPC分类号： A61M16/04
CPC分类号： A61M16/0488 , A61M2016/0413
摘要： A diagnostic monitor checks the carbon dioxide (CO.sub.2) content of a gas exiting a patient during endotracheal or esophageal intubation. A plurality of composition portions substantially change color in response to exposure to the carbon dioxide. The composition portions change color in response to different times of exposure to carbon dioxide. A magnifying or condensing lens may be positioned on the monitor to enhance viewing of the color change. The monitor may advantageously be made part of an intubation system through which the gases from a patient exit the patient. The differences in time of exposure needed to cause the color change may be accomplished by using semipermeable membranes having differing thicknesses, CO.sub.2 permeabilities, and/or surface areas with each membrane corresponding to a particular one of the composition portions. An arrangement is provided whereby the monitor is automatically activated by the normal assembly steps of a patient breathing circuit.
摘要翻译：诊断监测器检查在气管插管或食管插管期间离开患者的气体的二氧化碳（CO2）含量。多个组合物部分基于暴露于二氧化碳而显着改变颜色。组合物部分响应于暴露于二氧化碳的不同时间而改变颜色。可以将放大或聚光透镜放置在监视器上以增强对颜色变化的观察。可以有利地将监护仪制成插管系统的一部分，来自患者的气体通过该插管系统离开患者。导致颜色变化所需的曝光时间差异可以通过使用具有不同厚度的半透膜，CO 2渗透性和/或表面积来实现，其中每个膜对应于组合物部分的特定一个。提供了一种布置，由此通过患者呼吸回路的正常组装步骤自动启动监视器。

3. 发明授权

US6161537A Transtracheal energy application and sensing system for intubation: method and apparatus 失效
标题翻译：用于插管的气管内能量应用和感测系统：方法和装置
公开(公告)号：US6161537A
公开(公告)日：2000-12-19
申请号：US451811
申请日：1995-05-26
申请人： Dietrich Gravenstein , Nikolaus Gravenstein , Richard J. Melker , Samsun Lampotang , Anwer Sultan
发明人： Dietrich Gravenstein , Nikolaus Gravenstein , Richard J. Melker , Samsun Lampotang , Anwer Sultan
IPC分类号： A61M16/04 , A61M16/00
CPC分类号： A61M16/0488 , A61B5/0059 , A61B5/061
摘要： An intubation scope assembly adapted to facilitate the positioning of an endotracheal tube in a patient comprising an electromagnetic or sound energy source which enters the vocal cords exteriorly of the neck of the patient with energy having a direction, wavelength and intensity capable of entering the trachea, substantially avoiding encompassing the entire pharynx and capable of being transmitted cephalad substantially between and/or around the vocal cords. A suitable sensor for the energy emitted by such source comprises a stylet assembly, the distal end of which can detect or collect the energy transmitted between and/or around the vocal cords and the proximal end of which can monitor the detected or collected energy to thereby locate the vocal cords for positioning an endotracheal tube therebetween. A system and method of intubating a patient with the foregoing assembly are also disclosed.
摘要翻译：一种适于促进气管插管在患者中的定位的插管范围组件，包括电磁或声能量源，其以能够进入气管的方向，波长和强度的能量进入患者颈部外部的声带，基本上避免包围整个咽部并且能够基本上在声带之间和/或周围传播头脑。用于由这种源发射的能量的合适的传感器包括探针组件，该探针组件的远端可以检测或收集在声带之间和/或周围传播的能量，其近端可以监测所检测或收集的能量，从而找到用于将气管内管置于其间的声带。还公开了将患者插入前述组件的系统和方法。

4. 发明授权

US5560351A Transtracheal energy application and sensing system for intubation: method and apparatus 失效
公开(公告)号：US5560351A
公开(公告)日：1996-10-01
申请号：US319543
申请日：1994-10-07
申请人： Dietrich Gravenstein , Nikolaus Gravenstein , Richard J. Melker , Samsun Lampotang , Anwer Sultan
发明人： Dietrich Gravenstein , Nikolaus Gravenstein , Richard J. Melker , Samsun Lampotang , Anwer Sultan
IPC分类号： A61M16/04
CPC分类号： A61M16/0488 , A61B5/0059 , A61B5/061
摘要： An intubation scope assembly adapted to facilitate the positioning of an endotracheal tube in a patient comprising an electromagnetic or sound energy source which enters the vocal cords exteriorly of the neck of the patient with energy having a direction, wavelength and intensity capable of entering the trachea, substantially avoiding encompassing the entire pharynx and capable of being transmitted cephalad substantially between and/or around the vocal cords. A suitable sensor for the energy emitted by such source comprises a stylet assembly, the distal end of which can detect or collect the energy transmitted between and/or around the vocal cords and the proximal end of which can monitor the detected or collected energy to thereby locate the vocal cords for positioning an endotracheal tube therebetween. A system and method of intubating a patient with the foregoing assembly are also disclosed.

5. 发明授权

US5101825A Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination 失效
标题翻译：非侵入性间断和/或连续HEMOGLOBIN的方法，氧化内含物和HEMATOCRIT测定
公开(公告)号：US5101825A
公开(公告)日：1992-04-07
申请号：US368636
申请日：1989-06-20
申请人： Dietrich Gravenstein , J. E. W. Beneken , Samsun Lampotang , Nikolaus Gravenstein , Michael A. Brooks , Gordon L. Gibby , Robert J. Atwater
发明人： Dietrich Gravenstein , J. E. W. Beneken , Samsun Lampotang , Nikolaus Gravenstein , Michael A. Brooks , Gordon L. Gibby , Robert J. Atwater
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/14535 , A61B5/417
摘要： Described here are a novel means and device for noninvasively quantifying important blood constituents. Total hemoglobin, arterial oxygen content, hematocrit, and other parameters can all be determined quickly and easily without the need for skin puncture or lengthy laboratory analysis. The invention described here concerns the simultaneous measurement of volume changes and changes in the mass of either oxyhemoglobin, total hemoglobin, or reduced hemoglobin. The data obtained by these measurements is used to quantify the parameters of interest.
摘要翻译：这里描述的是用于非侵入性地量化重要血液成分的新颖手段和装置。总体血红蛋白，动脉氧含量，血细胞比容等参数都可以快速，容易地确定，无需皮肤穿刺或长时间的实验室分析。这里描述的发明涉及同时测量体积变化和氧合血红蛋白，总血红蛋白或还原血红蛋白质量的变化。通过这些测量获得的数据用于量化感兴趣的参数。

6. 发明授权

US08818472B2 Methods and devices for noninvasive measurement of energy absorbers in blood 有权
标题翻译：用于无创测量血液中能量吸收器的方法和装置
公开(公告)号：US08818472B2
公开(公告)日：2014-08-26
申请号：US12679721
申请日：2008-09-29
申请人： Dietrich Gravenstein , Mark Rice , Samsun Lampotang , Nikolaus Gravenstein , Lori Deitte
发明人： Dietrich Gravenstein , Mark Rice , Samsun Lampotang , Nikolaus Gravenstein , Lori Deitte
IPC分类号： A61B5/00
CPC分类号： A61B8/06 , A61B5/14552
摘要： Various embodiments of the present invention include devices for use in determining the concentration of a tissue energy absorber (e.g., hemoglobin) in an individual's blood. In particular embodiments, the device includes a photometric device (e.g., a pulse oximeter) and an imaging device (e.g., an ultrasound imaging device or other suitable imaging device), and the device is adapted for: (A) using the photometric device to measure a change in mass of the tissue energy absorber within a particular volume of the individual's blood between a first point in time and a second point in time, the particular volume of blood being blood within a particular portion of at least one vascular structure, the vascular structure comprising at least one of the individual's vessels (e.g., at least one of the individual's arteries); (B) using an ultrasound imaging device to measure a change in interior volume, between the first point in time and the second point in time, of the particular portion of the vascular structure; and (C) using both the measured change in the mass of the tissue energy absorber, and the measured change in interior volume to determine at least an approximate blood total concentration of the tissue energy absorber within the individual's blood.
摘要翻译：本发明的各种实施方案包括用于确定个体血液中的组织能量吸收剂（例如，血红蛋白）的浓度的装置。在特定实施例中，该装置包括测光装置（例如，脉搏血氧计）和成像装置（例如，超声成像装置或其它合适的成像装置），并且该装置适于：（A）使用光度装置测量在第一时间点和第二时间点之间的个体血液的特定体积内的组织能量吸收器的质量变化，血液的特定体积是至少一个血管结构的特定部分内的血液，血管结构包括个体血管中的至少一个（例如，个体动脉中的至少一个）; （B）使用超声成像装置来测量血管结构的特定部分的第一时间点和第二时间点之间的内部体积的变化; 和（C）使用所测量的组织能量吸收器的质量的变化和所测量的内部体积的变化来确定个体血液内的组织能量吸收器的至少近似血液总浓度。

7. 发明授权

US6115523A Plastic optical fiber airway imaging system 失效
标题翻译：塑料光纤气道成像系统
公开(公告)号：US6115523A
公开(公告)日：2000-09-05
申请号：US725779
申请日：1996-10-04
申请人： Won Young Choi , Dietrich Gravenstein , Samsun Lampotang , Richard Melker , James K. Walker
发明人： Won Young Choi , Dietrich Gravenstein , Samsun Lampotang , Richard Melker , James K. Walker
IPC分类号： A61B1/04 , A61B1/267 , A61B1/273 , G02B6/06
CPC分类号： A61B1/2676 , A61B1/0017 , A61B1/07 , A61B1/042
摘要： The subject invention pertains to a system for imaging the human airway having highly advantageous optical and physical characteristics. In a specific embodiment, the human airway can be imaged during the intubation procedure. The excellent characteristics of the imaging system of the subject invention result, in part, from the use of plastic optic fibers. Plastic fibers are more robust than the glass optical fibers used in currently available imaging systems, and are therefore capable of being bent and/or twisted with less concern of breakage. In addition, the lower costs of plastic fibers enables scopes of the subject invention, in a specific embodiment, to be manufactured for single patient use thereby eliminating the requirement for cleaning, special care, the maintenance of expensive inventory, and most importantly eliminating the opportunity for cross contamination between patients. A further aspect of the subject invention concerns a novel sheath which covers the portion of the imaging system which enters the patient. In this case, the sheath and its optional associated fiber optic illumination is disposable after each use.
摘要翻译：本发明涉及一种用于对具有非常有利的光学和物理特性的人气道成像的系统。在一个具体实施例中，人气道可以在插管过程中成像。本发明的成像系统的优异特征部分地导致使用塑料光纤。塑料纤维比当前可用的成像系统中使用的玻璃光纤更坚固，因此能够在较少的断裂的情况下弯曲和/或扭曲。此外，由于塑料纤维的成本较低，在一个具体实施例中，本发明的范围能够为单个患者使用而制造，从而消除了对清洁，特别护理，维护昂贵库存的要求，最重要的是消除了机会用于患者之间的交叉污染。本发明的另一方面涉及一种新颖的护套，其覆盖进入患者的成像系统的部分。在这种情况下，护套和其可选的相关联的光纤照明在每次使用之后是一次性的。

8. 发明授权

US06322498B1 Imaging scope 失效
标题翻译：成像范围
公开(公告)号：US06322498B1
公开(公告)日：2001-11-27
申请号：US09007939
申请日：1998-01-16
申请人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker , Andrea Gabrielli
发明人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker , Andrea Gabrielli
IPC分类号： A61B1267
CPC分类号： A61B1/2676 , A61B1/00165 , A61B1/042 , A61B1/05 , A61B1/07
摘要： The subject invention pertains to a system for imaging the human airway having highly advantageous optical, mechanical, ergonomical and physical characteristics. In a specific embodiment, the human airway can be imaged during the intubation procedure. The subject imaging scopes can incorporate a malleable stylet which retains its shape when bent, in order to facilitate intubation of a patient. In a preferred embodiment, a solid metal stylet, for example, a conventional endotracheal tube stylet, can be utilized. In a specific embodiment the subject intubation scope allows for a user to utilize conventional techniques for the insertion of an endotracheal tube, reducing the training needed for use of the subject intubation scope. Preferably, the subject imaging scopes also incorporate at least one illumination fiber to convey light to the distal tip of the subject imaging scopes, for illumination of the objects to be imaged.
摘要翻译：本发明涉及一种用于对具有高度有利的光学，机械，人体工程学和物理特性的人类气道成像系统。在一个具体实施例中，人气道可以在插管过程中成像。主题成像范围可以包括弯曲时保持其形状的可延展的管心针，以便于患者的插管。在优选实施例中，可以使用固体金属探针，例如常规的气管内导管探针。在具体实施例中，所述插管范围允许使用者利用常规技术来插入气管插管，减少使用所述受试者插管范围所需的训练。优选地，本发明的成像范围还包括至少一个照明光纤以将光传送到目标成像范围的远侧末端，以照射待成像的物体。

9. 发明申请

US20050182297A1 Imaging scope 审中-公开
标题翻译：成像范围
公开(公告)号：US20050182297A1
公开(公告)日：2005-08-18
申请号：US10982154
申请日：2004-11-05
申请人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker
发明人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker
IPC分类号： A61B1/04 , A61B1/267 , A61M16/04 , A61B1/00 , A62B9/06
CPC分类号： A61B1/2676 , A61B1/00167 , A61B1/0017 , A61B1/042 , A61B1/07 , A61B5/064
摘要： Disclosed is an intubation imaging stylet for intubating a patient by use in a tube/imaging stylet combination, said imaging stylet comprising: a malleable stylet having a longitudinal axis and a proximal end and a distal end; a flexible image guide having a longitudinal axis and a proximal end and a distal end, said image guide being connected to said stylet such that a portion of said image guide runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said image guide is co-extensive with the distal end of said stylet; and at least one flexible illumination fiber having a proximal end and a distal end, said illumination fiber being connected to said stylet such that a portion of said illumination fiber runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said illumination fiber is co-extensive with the distal end of said stylet; such that in use, said imaging stylet is disposed within a tube for intubating a patient thereby forming an imaging stylet/tube combination which in use is held by gripping the tube in a pen-like fashion. The imaging stylet/tube combination is thus in use held in one hand, freeing the other hand of the user for other tasks if necessary, as well as permitting intubation in the conventional manner. To facilitate this, the center of gravity of the imaging stylet/tube combination is located in essentially the same location along the tube as with a conventional stylet/tube combination.
摘要翻译：公开了一种插管成像探针，用于通过使用管/成像探针组合来插入患者，所述成像探针包括：具有纵向轴线和近端和远端的可延展的探针; 具有纵向轴线和近端和远端的柔性图像引导件，所述图像引导件连接到所述探针，使得所述图像引导件的一部分沿着所述探针的纵向轴线平行于所述探针的一部分平行，所述图像引导件的远端与所述探针的远端共同延伸; 以及至少一个具有近端和远端的柔性照明光纤，所述照明光纤连接到所述探针，使得所述照明光纤的一部分沿着所述探针的纵向轴线平行于所述探针的一部分延伸，并且使得所述照明光纤的远端与所述探针的远端共同延伸; 使得在使用中，所述成像探针设置在用于插管患者的管内，从而形成成像探针/管组合，其在使用中通过以笔状夹持管来保持。因此，一方面使用成像探针/管组合，如果必要，释放用户的另一只手用于其他任务，并且以常规方式允许插管。为了促进这一点，成像探针/管组合的重心位于沿着管的基本相同的位置，与传统的探针/管组合一样。

10. 发明申请

US20100286515A1 Novel Methods and Devices for Noninvasive Measurement of Energy Absorbers in Blood 有权
标题翻译：用于无创测量血液中能量吸收器的新方法和设备
公开(公告)号：US20100286515A1
公开(公告)日：2010-11-11
申请号：US12679721
申请日：2008-09-29
申请人： Dietrich Gravenstein , Mark Rice , Sanisun Lanipotang , Nikolaus Gravenstein , Lori Deitte
发明人： Dietrich Gravenstein , Mark Rice , Sanisun Lanipotang , Nikolaus Gravenstein , Lori Deitte
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , A61B5/14552
摘要： Various embodiments of the present invention include devices for use in determining the concentration of a tissue energy absorber (e.g., hemoglobin) in an individual's blood. In particular embodiments, the device includes a photometric device (e.g., a pulse oximeter) and an imaging device (e.g., an ultrasound imaging device or other suitable imaging device), and the device is adapted for: (A) using the photometric device to measure a change in mass of the tissue energy absorber within a particular volume of the individual's blood between a first point in time and a second point in time, the particular volume of blood being blood within a particular portion of at least one vascular structure, the vascular structure comprising at least one of the individual's vessels (e.g., at least one of the individual's arteries); (B) using an ultrasound imaging device to measure a change in interior volume, between the first point in time and the second point in time, of the particular portion of the vascular structure; and (C) using both the measured change in the mass of the tissue energy absorber, and the measured change in interior volume to determine at least an approximate blood total concentration of the tissue energy absorber within the individual's blood.
摘要翻译：本发明的各种实施方案包括用于确定个体血液中的组织能量吸收剂（例如，血红蛋白）的浓度的装置。在特定实施例中，该装置包括测光装置（例如，脉搏血氧计）和成像装置（例如，超声成像装置或其它合适的成像装置），并且该装置适于：（A）使用光度装置测量在第一时间点和第二时间点之间的个体血液的特定体积内的组织能量吸收器的质量变化，血液的特定体积是至少一个血管结构的特定部分内的血液，血管结构包括个体血管中的至少一个（例如，个体动脉中的至少一个）; （B）使用超声成像装置来测量血管结构的特定部分的第一时间点和第二时间点之间的内部体积的变化; 和（C）使用所测量的组织能量吸收器的质量的变化和所测量的内部体积的变化来确定个体血液内的组织能量吸收器的至少近似血液总浓度。

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