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1. 发明申请

US20070110808A1 Extended release osmo-microsealed formulation 审中-公开
标题翻译：延长释放的渗透微密封制剂
公开(公告)号：US20070110808A1
公开(公告)日：2007-05-17
申请号：US10563631
申请日：2004-05-14
申请人： Sampad Bhattacharya , Sridhar Gummudavelli , Mayank Joshi , John Egbert
发明人： Sampad Bhattacharya , Sridhar Gummudavelli , Mayank Joshi , John Egbert
IPC分类号： A61K31/137 , A61K9/24
CPC分类号： A61K9/2846 , A61K9/0004 , A61K9/2077 , A61K9/2081 , A61K9/5042 , A61K9/5047
摘要： The extended release osmo-microsealed formulation includes three controlled release systems associated in series. First, there is an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle. Second, there is an outer solid continuous phase including one or more hydrophilic polymers, that is further compressed into a tablet. Third, there is an optional functional coat surrounding the tablet. The process/method for forming the Osmo-microsealed extended release delivery system and the process for using such system for treating human ailment/depression are also provided.
摘要翻译：延长释放的渗透微密封制剂包括三个相互联系的控制释放系统。首先，存在含有盐酸文拉法辛（活性）的内固体颗粒相和一种或多种疏水性聚合物，一种或多种稀释剂，以增加体积的一种或多种渗透剂（可以在疏水涂层上产生渗透压的试剂）和一种或更多的粘合剂聚合物基本上为颗粒提供强度/硬度。第二，存在包含一种或多种亲水性聚合物的外部固体连续相，其进一步压缩成片剂。第三，围绕平板电脑有一个可选的功能外套。还提供了用于形成Osmo-微密封延长释放递送系统的方法/方法以及使用该系统治疗人类疾病/抑郁症的方法。

2. 发明授权

US07807195B2 Extended release formulation of venlafaxine hydrochloride 有权
标题翻译：盐酸文拉法辛缓释制剂
公开(公告)号：US07807195B2
公开(公告)日：2010-10-05
申请号：US11031266
申请日：2005-01-07
申请人： Sampad Bhattacharya , Rajesh Kshirsagar , Mayank Joshi , Sandeep Pandita
发明人： Sampad Bhattacharya , Rajesh Kshirsagar , Mayank Joshi , Sandeep Pandita
IPC分类号： A61K9/64 , A61K9/52 , A61K9/20
CPC分类号： A61K9/4808 , A61K9/2866 , A61K31/137
摘要： The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.
摘要翻译：本发明涉及包含盐酸文拉法辛和药学上可接受的赋形剂的每日一次药物制剂。更具体地说，本发明涉及一种微胶囊形式的延缓释放组合物，其被并入硬明胶胶囊中。

3. 发明申请

US20050169985A1 Extended release formulation of venlafaxine hydrochloride 有权
标题翻译：盐酸文拉法辛缓释制剂
公开(公告)号：US20050169985A1
公开(公告)日：2005-08-04
申请号：US11031266
申请日：2005-01-07
申请人： Sampad Bhattacharya , Rajesh Kshirsagar , Mayank Joshi , Sandeep Pandita
发明人： Sampad Bhattacharya , Rajesh Kshirsagar , Mayank Joshi , Sandeep Pandita
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K31/137 , A61K9/64 , A61K9/52
CPC分类号： A61K9/4808 , A61K9/2866 , A61K31/137
摘要： The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.
摘要翻译：本发明涉及包含盐酸文拉法辛和药学上可接受的赋形剂的每日一次药物制剂。更具体地说，本发明涉及一种微胶囊形式的延缓释放组合物，其被并入硬明胶胶囊中。

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