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1. 发明申请

US20070072885A1 BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH 审中-公开
标题翻译：用于治疗异常细胞生长的双相衍生物
公开(公告)号：US20070072885A1
公开(公告)日：2007-03-29
申请号：US11422235
申请日：2006-06-05
申请人： Samit Bhattacharya , Chandra Prakash
发明人： Samit Bhattacharya , Chandra Prakash
IPC分类号： A61K31/517 , C07D403/02
CPC分类号： C07D239/94 , C07D401/12
摘要： The invention relates to substantially pure compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R5, and X are as defined herein, and wherein the compound of formula 1 optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N−>O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders that contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译：本发明涉及基本上纯的式1化合物及其药学上可接受的盐，前药和溶剂化物，其中R 1，R 2，R 3， R 5，R 5如本文所定义，并且其中式1化合物任选地进一步包含羟基取代基，O-葡萄糖醛酸或N-（O-氧化物））部分。本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。

2. 发明申请

US20060287336A1 S-methyl-dihydro-ziprasidone for treatment of psychiatric and ocular disorders 审中-公开
标题翻译： S-甲基 - 二氢 - 齐拉昔酮用于治疗精神病和眼部疾病
公开(公告)号：US20060287336A1
公开(公告)日：2006-12-21
申请号：US09873973
申请日：2001-06-04
申请人： Chandra Prakash , Terese Smolarek
发明人： Chandra Prakash , Terese Smolarek
IPC分类号： A61K31/496
CPC分类号： A61K31/22 , A61K31/496
摘要： This invention relates to pharmaceutical compositions containing S-methyl-dihydro-ziprasidone and to the use of such compound and its pharmaceutically acceptable salts for the treatment of psychiatric and ocular disorders. More specifically, it relates to the use of such compound and its pharmaceutically acceptable salts for the treatment of a disorder or condition selected from: schizophrenia, anxiety disorders such as generalized anxiety disorder, panic disorder, posttraumatic stress disorder and phobias (e.g., social phobia, agoraphobia etc.); psychotic episodes of anxiety: anxiety, agitation, excessive aggression, tension, or social or emotional withdrawal associated with psychosis; psychotic mood disorders such as severe major depressive disorder; mood disorders associated with psychotic disorders such as acute mania and depression associated with bipolar disorder, and mood disorders associated with schizophrenia; behavioral disturbances associated with mental retardation, autistic disorder, and conduct disorder; dementias such as dementias associated with Alzheimer's disease; drug-induced and neurodegeneration based dyskinesias; obsessive compulsive disorder; Tourette's syndrome; glaucoma; and ischemic retinopathy.
摘要翻译：本发明涉及含有S-甲基 - 二氢 - 齐拉西酮的药物组合物以及这种化合物及其可药用盐在治疗精神病和眼部疾病中的用途。更具体地说，它涉及这种化合物及其药学上可接受的盐在治疗选自以下的病症或病症中的用途：精神分裂症，焦虑症例如广泛性焦虑症，惊恐障碍，创伤后应激障碍和恐惧症（例如社交恐惧症，广场恐怖等）; 焦虑的精神病发作：与精神病有关的焦虑，激动，过度侵略，紧张或社会或情绪退缩; 精神病心理障碍如重度抑郁障碍; 与精神病性疾病相关的情绪障碍，例如与双相障碍相关的急性躁狂症和抑郁症，以及与精神分裂症相关的情绪障碍; 与精神发育迟滞，自闭症和行为障碍相关的行为障碍; 痴呆症如与阿尔茨海默病相关的痴呆; 药物诱导和神经退行性运动障碍; 强迫症图雷特综合征青光眼; 和缺血性视网膜病变。

3. 发明申请

US20050268536A1 DIESEL MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：柴油机燃油添加剂组合物
公开(公告)号：US20050268536A1
公开(公告)日：2005-12-08
申请号：US10709872
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18 , C10L1/22 , C10L1/238 , C10L1/2383 , C10L10/02
CPC分类号： C10L1/238 , C10L1/2383 , C10L1/2387 , C10L10/02 , C10L10/12
摘要： Disclosed is a diesel fuel additive composition which accelerates combustion phenomenon, reduces ignition delay, and improves Cetane number, thereby lowering particulate emissions, and improving fuel economy in diesel engines.
摘要翻译：公开了一种加速燃烧现象，减少点火延迟并提高十六烷值，从而降低颗粒物排放并提高柴油发动机燃油经济性的柴油燃料添加剂组合物。

4. 发明申请

US20050268534A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20050268534A1
公开(公告)日：2005-12-08
申请号：US10709866
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18
CPC分类号： C10L1/143 , C10L1/1805 , C10L1/1852 , C10L1/1985 , C10L1/201 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L1/306 , C10L10/04
摘要： Disclosed is a leaded motor fuel additive composition which synergistically interacts with the alkyl lead additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含铅马达燃料添加剂组合物，其与烷基铅添加剂协同地相互作用以减少燃料进料系统沉积物形成和燃烧室沉积物形成，由此减少发动机ORI并保持期望的发动机性能。

5. 发明申请

US20090158643A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20090158643A1
公开(公告)日：2009-06-25
申请号：US12398329
申请日：2009-03-05
申请人： Otis L. Nelson, JR. , Mark L. Nelson , A. Richard Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis L. Nelson, JR. , Mark L. Nelson , A. Richard Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18
CPC分类号： C10L1/143 , C10L1/1805 , C10L1/1824 , C10L1/1852 , C10L1/1985 , C10L1/201 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L1/306 , C10L10/00 , C10L10/02 , C10L10/10
摘要： Disclosed is a leaded motor fuel additive composition which synergistically interacts with the alkyl lead additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含铅马达燃料添加剂组合物，其与烷基铅添加剂协同地相互作用以减少燃料进料系统沉积物形成和燃烧室沉积物形成，由此减少发动机ORI并保持期望的发动机性能。

6. 发明申请

US20090158642A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20090158642A1
公开(公告)日：2009-06-25
申请号：US12398319
申请日：2009-03-05
申请人： Otis L. Nelson, JR. , Mark L. Nelson , A. Richard Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis L. Nelson, JR. , Mark L. Nelson , A. Richard Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18
CPC分类号： C10L1/143 , C10L1/1805 , C10L1/1824 , C10L1/1852 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L1/305 , C10L10/00 , C10L10/10
摘要： Disclosed is a MMT containing motor fuel additive composition which synergistically interacts with the MMT additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含有MMT的机动车燃料添加剂组合物，其与MMT添加剂协同地相互作用以减少燃料进入系统沉积物形成和燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

7. 发明申请

US20050268531A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20050268531A1
公开(公告)日：2005-12-08
申请号：US10709861
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/14 , C10L1/18 , C10L1/22 , C10L10/00
CPC分类号： C10L1/14 , C10L1/18 , C10L1/1824 , C10L1/1852 , C10L1/198 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L10/04
摘要： Disclosed is an alcohol containing motor fuel additive composition which synergistically interacts with the alcohol additive to reduce fuel intake system deposit formation and/or combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含醇的运动燃料添加剂组合物，其与醇添加剂协同地相互作用以减少燃料进入系统沉积物形成和/或燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

8. 发明申请

US20050268537A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20050268537A1
公开(公告)日：2005-12-08
申请号：US10709873
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/14 , C10L1/18 , C10L1/22 , C10L1/30 , C10L10/06 , C10L10/10
CPC分类号： C10L10/10 , C10L1/14 , C10L1/143 , C10L1/1852 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/301 , C10L10/06
摘要： Disclosed is a ferrocene containing motor fuel additive composition which synergistically combines the octane enhancing capabilities of ferrocene with the benefits of a special additive package to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含二茂铁的运动燃料添加剂组合物，其协同地将二茂铁的辛烷值增强能力与特殊添加剂包装的优点相结合，以减少燃料进料系统沉积物形成和燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

9. 发明申请

US20050268535A1 BIODIESEL MOTOR FULE ADDITIVE COMPOSITION 审中-公开
标题翻译：生物体电动机燃料添加剂组合物
公开(公告)号：US20050268535A1
公开(公告)日：2005-12-08
申请号：US10709868
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18
CPC分类号： C10L10/02 , C10L1/143 , C10L1/1805 , C10L1/1852 , C10L1/19 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L10/12
摘要： Disclosed is a biodiesel fuel additive composition which accelerates combustion phenomenon, reduces ignition delay, and improves Cetane number, thereby lowering particulate emissions, and improving fuel economy in diesel engines.
摘要翻译：公开了一种生物柴油燃料添加剂组合物，其加速燃烧现象，减少点火延迟，并提高十六烷值，从而降低颗粒物排放，并提高柴油发动机的燃油经济性。

10. 发明申请

US20050268533A1 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：US20050268533A1
公开(公告)日：2005-12-08
申请号：US10709863
申请日：2004-06-02
申请人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
发明人： Otis Nelson , Mark Nelson , A. Nelson , Chandra Prakash , Gilbert Chapelet
IPC分类号： C10L1/18
CPC分类号： C10L1/14 , C10L1/143 , C10L1/1805 , C10L1/1852 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L10/04
摘要： Disclosed is an ether containing motor fuel additive composition which synergistically interacts with the ether additive to reduce fuel intake system deposit formation and/or combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含醚的运动燃料添加剂组合物，其与醚添加剂协同相互作用以减少燃料进入系统沉积物形成和/或燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

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