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1. 发明授权

US07727558B2 Polymeric delivery agents and delivery agent compounds 失效
标题翻译：聚合物递送剂和递送剂化合物
公开(公告)号：US07727558B2
公开(公告)日：2010-06-01
申请号：US11669649
申请日：2007-01-31
申请人： Sam J. Milstein , Eugene N. Barantsevitch , Nai Fang Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
发明人： Sam J. Milstein , Eugene N. Barantsevitch , Nai Fang Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
IPC分类号： A61K9/50
CPC分类号： C08G65/33396 , A61K9/0019 , A61K38/27 , A61K38/29 , A61K47/10 , A61K47/32 , A61K47/56 , A61K47/60 , C08F8/30 , C08G65/329 , C08L2203/02
摘要： Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的聚合物递送剂，递送剂化合物和包含它们的组合物。也提供给药和制备方法。

2. 发明申请

US20070141022A1 POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS 失效
标题翻译：聚合物递送代理和交付代理化合物
公开(公告)号：US20070141022A1
公开(公告)日：2007-06-21
申请号：US11669649
申请日：2007-01-31
申请人： Sam Milstein , Eugene Barantsevitch , Nai Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
发明人： Sam Milstein , Eugene Barantsevitch , Nai Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
IPC分类号： A61K38/17 , A61K31/785 , C08G63/91
CPC分类号： C08G65/33396 , A61K9/0019 , A61K38/27 , A61K38/29 , A61K47/10 , A61K47/32 , A61K47/56 , A61K47/60 , C08F8/30 , C08G65/329 , C08L2203/02
摘要： Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的聚合物递送剂，递送剂化合物和包含它们的组合物。也提供给药和制备方法。

3. 发明授权

US08410309B2 Phenoxy carboxylic acid compounds and compositions for delivering active agents 有权
标题翻译：苯氧基羧酸化合物和用于递送活性剂的组合物
公开(公告)号：US08410309B2
公开(公告)日：2013-04-02
申请号：US11458331
申请日：2006-07-18
申请人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gschneidner , Maria Aurora P. Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John J. Freeman, Jr.
发明人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gschneidner , Maria Aurora P. Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John J. Freeman, Jr.
IPC分类号： C07C59/90 , C07C62/32 , C07C65/40
CPC分类号： C07C59/64 , C07C59/42 , C07C59/56 , C07C59/74 , C07C59/84 , C07C59/90 , C07C63/14
摘要： Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了苯氧基羧酸化合物和用于递送活性剂的组合物。也提供给药和制备方法。

4. 发明申请

US20060264513A1 PHENOXY CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 有权
标题翻译：苯甲酸羧酸化合物和用于递送活性剂的组合物
公开(公告)号：US20060264513A1
公开(公告)日：2006-11-23
申请号：US11458331
申请日：2006-07-18
申请人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gschneidner , Maria Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John Freeman
发明人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gschneidner , Maria Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John Freeman
IPC分类号： A61K31/19
CPC分类号： C07C59/64 , C07C59/42 , C07C59/56 , C07C59/74 , C07C59/84 , C07C59/90 , C07C63/14
摘要： Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了苯氧基羧酸化合物和用于递送活性剂的组合物。也提供给药和制备方法。

5. 发明授权

US07951971B1 Phenoxy carboxylic acid compounds and compositions for delivering active agents 有权
标题翻译：苯氧基羧酸化合物和用于递送活性剂的组合物
公开(公告)号：US07951971B1
公开(公告)日：2011-05-31
申请号：US12139276
申请日：2008-06-13
申请人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gscheidner , Maria Aurora P. Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John J. Freeman, Jr.
发明人： Andrea Leone-Bay , Kelly Kraft , Destardi Moye-Sherman , David Gscheidner , Maria Aurora P. Boyd , Puchun Liu , Pingwah Tang , Jun Liao , John Smart , John J. Freeman, Jr.
IPC分类号： C07C65/30
CPC分类号： C07C59/64 , C07C59/42 , C07C59/56 , C07C59/74 , C07C59/84 , C07C59/90 , C07C63/14
摘要： Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了苯氧基羧酸化合物和用于递送活性剂的组合物。也提供给药和制备方法。

6. 发明申请

US20050176627A1 Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin 审中-公开
标题翻译：维持内源促红细胞生成素组织保护活性的长效促红细胞生成素
公开(公告)号：US20050176627A1
公开(公告)日：2005-08-11
申请号：US11075957
申请日：2005-03-09
申请人： Anthony Cerami , John Smart , Michael Brines , Carla Cerami
发明人： Anthony Cerami , John Smart , Michael Brines , Carla Cerami
IPC分类号： A61K38/18 , A61K47/48 , C07K14/505
CPC分类号： A61K38/1816 , A61K47/60
摘要： Methods for increasing the hematocrit of an individual while maintaining the tissue protective activities of endogenous erythropoietin through the administration of a pharmaceutical compound containing chemically modified long acting erythropoietin. Also disclosed are the new chemically modified long acting erythropoietins, methods of producing the chemically modified long acting erythropoietins, and compositions comprising the chemically modified long acting erythropoietins.
摘要翻译：通过施用含有化学修饰的长效促红细胞生成素的药物化合物，维持内源促红细胞生成素的组织保护活性，增加个体的血细胞比容的方法。还公开了新的化学改性的长效促红细胞生成素，生产化学改性的长效促红细胞生成素的方法和包含化学改性的长效促红细胞生成素的组合物。

7. 发明申请

US20050096339A1 Morphogen-induced modulation of inflammatory response 审中-公开
标题翻译：形态诱导的炎症反应调节
公开(公告)号：US20050096339A1
公开(公告)日：2005-05-05
申请号：US10865514
申请日：2004-06-09
申请人： Thangavel Kuberasampath , Roy Pang , Hermann Oppermann , David Rueger , Charles Cohen , Engin Ozkaynak , John Smart
发明人： Thangavel Kuberasampath , Roy Pang , Hermann Oppermann , David Rueger , Charles Cohen , Engin Ozkaynak , John Smart
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , A61K31/485
CPC分类号： A61K38/17 , A01N1/0226 , A61F2310/00365 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
摘要： The present invention is directed to methods and compositions for alleviating tissue destructive effects associated with the inflammatory response to tissue injury in a mammal. The methods and compositions include administering a therapeutically effective concentration of a morphogen or morphogen-stimulating agent sufficient to alleviate immune cell-mediated tissue destruction.
摘要翻译：本发明涉及减轻与哺乳动物对组织损伤的炎症反应相关的组织破坏作用的方法和组合物。所述方法和组合物包括施用足以减轻免疫细胞介导的组织破坏的治疗有效浓度的形态发生剂或形态发生剂。

8. 发明申请

US20060025571A1 Morphogen-induced dendritic growth 审中-公开
标题翻译：形态诱导树突生长
公开(公告)号：US20060025571A1
公开(公告)日：2006-02-02
申请号：US11226555
申请日：2005-09-13
申请人： David Rueger , Kuber Sampath , John Smart , Hermann Oppermann , Engin Ozkaynak , Charles Cohen , Dennis Higgins
发明人： David Rueger , Kuber Sampath , John Smart , Hermann Oppermann , Engin Ozkaynak , Charles Cohen , Dennis Higgins
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/51 , A01N1/021 , A61K38/00 , A61K38/1841 , A61K38/185
摘要： Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.
摘要翻译：公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。形态发生剂和神经营养因子可以组合使用。

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