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1. 发明申请

US20090197856A1 ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：有害化合物
公开(公告)号：US20090197856A1
公开(公告)日：2009-08-06
申请号：US12339460
申请日：2008-12-19
申请人： Salvador G. Alvarez , Janos Botyanszki , Joseph de los Angeles , Jiping Fu , Roger Fujimoto , Joshua Michael Gralapp , Ronald Conrad Griffith , Peichao Lu , Son Minh Pham , Christopher Don Roberts , Franz Ulrich Schmitz , Mohindra Seepersaud , Ruben Tommasi , Adam Christopher Villa , Sompong Wattanasin , Aregahagn Yifru , Rui Zheng , Xiaoling Zheng
发明人： Salvador G. Alvarez , Janos Botyanszki , Joseph de los Angeles , Jiping Fu , Roger Fujimoto , Joshua Michael Gralapp , Ronald Conrad Griffith , Peichao Lu , Son Minh Pham , Christopher Don Roberts , Franz Ulrich Schmitz , Mohindra Seepersaud , Ruben Tommasi , Adam Christopher Villa , Sompong Wattanasin , Aregahagn Yifru , Rui Zheng , Xiaoling Zheng
IPC分类号： A61K31/407 , C07D487/14 , A61K31/454 , A61K31/5377 , A61K31/551 , A61K31/5355 , A61K31/496 , A61K31/541 , A61K31/437 , A61P31/12
CPC分类号： C07D471/22 , C07D487/14 , C07D487/22
摘要： Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.
摘要翻译：提供式（I）的化合物或其药学上可接受的盐或溶剂化物。化合物和组合物可用于治疗由黄病毒科病毒引起的病毒感染。

2. 发明申请

US20090253648A1 Tricyclic-Nucleoside Compounds for Treating Viral Infections 审中-公开
标题翻译：用于治疗病毒感染的三环核苷化合物
公开(公告)号：US20090253648A1
公开(公告)日：2009-10-08
申请号：US12415335
申请日：2009-03-31
申请人： Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
发明人： Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/14
CPC分类号： C07D487/16 , C07H19/00 , C07H19/22 , C07H19/23
摘要： Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
摘要翻译：公开了由式I，II和III表示的化合物及其用于治疗由黄病毒科家族病毒引起的病毒感染的组合物和方法。

3. 发明申请

US20090048189A1 TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：用于治疗病毒感染的TRICYCLIC-NUCLEOSIDE化合物
公开(公告)号：US20090048189A1
公开(公告)日：2009-02-19
申请号：US11839380
申请日：2007-08-15
申请人： Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
发明人： Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/14
CPC分类号： C07H19/23
摘要： Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.
摘要翻译：公开了式（I）的三环核苷化合物及其至少部分由黄病毒科家族病毒介导的病毒感染的方法。

4. 发明申请

US20090062223A1 AMINO TRICYCLIC-NUCLEOSIDE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：氨基三核 - 核苷酸化合物，组合物和使用方法
公开(公告)号：US20090062223A1
公开(公告)日：2009-03-05
申请号：US12201692
申请日：2008-08-29
申请人： Jesse Daniel Keicher , Christopher Don Roberts , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Xiaoling Zheng , Sebastian Johannes Reinhard Liehr , Marija Prhavc , Choung U. Kim , Adrian S. Ray
发明人： Jesse Daniel Keicher , Christopher Don Roberts , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Xiaoling Zheng , Sebastian Johannes Reinhard Liehr , Marija Prhavc , Choung U. Kim , Adrian S. Ray
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/14
CPC分类号： C07H19/23
摘要： Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.
摘要翻译：提供式（I）的化合物或其药学上可接受的盐或溶剂化物。化合物和组合物可用于治疗由黄病毒科病毒引起的病毒感染。

5. 发明授权

US08771665B2 Inhibitors of hepatitis C virus polymerase 有权
标题翻译：丙型肝炎病毒聚合酶抑制剂
公开(公告)号：US08771665B2
公开(公告)日：2014-07-08
申请号：US13328036
申请日：2011-12-16
申请人： Sam S K Lee , Wang Shen , Xiaoling Zheng , Irina C. Jacobson
发明人： Sam S K Lee , Wang Shen , Xiaoling Zheng , Irina C. Jacobson
IPC分类号： A61K38/21
CPC分类号： C07D401/04 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/519 , A61K31/7056 , A61K38/21 , A61K38/212 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
摘要翻译：本发明尤其提供由通式I表示的化合物及其药学上可接受的盐，其中X，Y，R 1A，R 1B，R 2和R 3如本文中的类别和亚类所定义，组合物（例如药物组合物），该化合物可用作丙型肝炎病毒聚合酶的抑制剂，因此可用作例如用于治疗HCV感染的药物。

6. 发明授权

US06939685B2 Stabilized tetrazolium phenazine reagent compositions and methods for using the same 有权
标题翻译：稳定的四唑吩嗪试剂组合物及其使用方法
公开(公告)号：US06939685B2
公开(公告)日：2005-09-06
申请号：US09988494
申请日：2001-11-20
申请人： Tianmei Ouyang , Paing Huang , Xiaoling Zheng
发明人： Tianmei Ouyang , Paing Huang , Xiaoling Zheng
IPC分类号： G01N33/50 , C12Q1/25 , C12Q1/26 , G01N21/78 , G01N31/22 , G01N33/52 , G01N33/66 , A01N59/06 , A61K38/43 , A61K38/44 , C12N9/02 , C12Q1/32
CPC分类号： C12Q1/26 , G01N33/52
摘要： Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a tetrazolium dye component, e.g., a water soluble tetrazolium salt; (2) a phenazine component; and (3) an effective amount of one or more tetrazolium dye-phenazine stabilizing reagents, e.g., an inorganic Group IIIA compound and/or a flavin. In many embodiments, the subject reagent compositions include additional members of an analyte oxidizing signal producing system, such as: an analyte oxidizing enzyme, e.g., an analyte dehydrogenase or an analyte oxidase; and an enzyme cofactor. Also provided are test strips that include the subject reagent compositions, as well as systems and kits incorporating the subject test strips. The subject reagent compositions, test strips, systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof, or ISF (interstitial fluid).
摘要翻译：提供稳定的四唑染料 - 吩嗪试剂组合物及其用于测量样品中分析物的方法。主题试剂组合物包括：（1）四唑鎓染料组分，例如水溶性四唑鎓盐; （2）吩嗪组分; 和（3）有效量的一种或多种四唑染料 - 吩嗪稳定试剂，例如无机IIIA族化合物和/或黄素。在许多实施方案中，主题试剂组合物包括分析物氧化信号产生系统的附加成员，例如：分析物氧化酶，例如分析物脱氢酶或分析物氧化酶; 和酶辅因子。还提供了包括主题试剂组合物的测试条，以及包含主题测试条的系统和试剂盒。主题试剂组合物，测试条，系统和试剂盒可用于检测样品中各种分析物，例如生理样品，例如血液或其部分，或ISF（间质液）。

7. 发明申请

US20140221406A1 QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE 有权
标题翻译：喹唑啉-7-醚化合物及其使用方法
公开(公告)号：US20140221406A1
公开(公告)日：2014-08-07
申请号：US14118200
申请日：2012-05-17
申请人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
发明人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC分类号： C07D405/12 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
摘要翻译：本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。

8. 发明申请

US20120196833A1 PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE 有权
标题翻译：含有喹唑啉化合物的磷酸盐及其使用方法
公开(公告)号：US20120196833A1
公开(公告)日：2012-08-02
申请号：US13380808
申请日：2010-07-02
申请人： Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
发明人： Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
IPC分类号： A61K31/675 , A61P35/00 , C07F9/6571 , C07F9/6584 , C07F9/655
CPC分类号： C07F9/65685 , C07F9/65128 , C07F9/65586 , C07F9/657181
摘要： Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.
摘要翻译：公开了含磷取代的新型喹唑啉衍生物和使用该化合物治疗过度增殖性疾病（例如癌症）的方法。这些化合物是I型受体蛋白激酶抑制剂，可用于治疗与异常蛋白激酶活性相关的疾病，例如哺乳动物的癌症和炎症。还公开了含有化合物的药物组合物，制备化合物的方法及其药学上可接受的盐。

9. 发明授权

US06218571B1 8-(anilino)-1-naphthalenesulfonate analogs 有权
标题翻译： 8-（苯胺基）-1-萘磺酸酯类似物
公开(公告)号：US06218571B1
公开(公告)日：2001-04-17
申请号：US09428296
申请日：1999-10-27
申请人： Xiaoling Zheng , Yeung Siu Yu , Adva Yani , Paing C. Huang
发明人： Xiaoling Zheng , Yeung Siu Yu , Adva Yani , Paing C. Huang
IPC分类号： C07C30900
CPC分类号： C07C309/47 , C09B27/00 , C12Q1/28 , C12Q1/54 , C12Q2326/00 , C12Q2326/32
摘要： 8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-2-benzothiazolinone hydrazone hydrchloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by the formula: wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.
摘要翻译：提供了8-（苯胺基）-1-萘磺酸盐（ANS）类似物及其在分析物检测测定中的应用。主题ANS类似物的特征在于在其苯基部分上具有至少一个非氢取代基，并产生与3-甲基-2-苯并噻唑啉酮腙盐酸盐（MBTH）或其类似物的反应产物。 MBTHSB，减少漂移。在某些优选实施方案中，主题ANS类似物由下式描述：其中：n为1至5; X是除H之外的取代基。主题ANS类似物可用于各种应用，特别是在分析物检测测定中，例如葡萄糖检测测定。

10. 发明授权

US09187459B2 Quinazoline-7-ether compounds and methods of use 有权
标题翻译：喹唑啉-7-醚化合物及其使用方法
公开(公告)号：US09187459B2
公开(公告)日：2015-11-17
申请号：US14118200
申请日：2012-05-17
申请人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
发明人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00 , C07D239/72 , C07D405/12 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
摘要翻译：本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。

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