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1. 发明申请

US20040048339A1 Human proteins having transmembrane domains and cDNAs encoding these proteins 审中-公开
标题翻译：具有跨膜结构域的人蛋白质和编码这些蛋白质的cDNA
公开(公告)号：US20040048339A1
公开(公告)日：2004-03-11
申请号：US10616942
申请日：2003-07-11
申请人： Sagami Chemical Research Center , Protegene, Inc.
发明人： Seishi Kato , Shingo Sekine
IPC分类号： C07K014/705 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C07K14/705
摘要： The invention provides human proteins having transmembrane domains and cDNAs coding for these proteins as well as eucaryotic cells expressing said cDNAs. All of the proteins exist in the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals such as carcinostatic agents relating to the control of the proliferation and the differentiation of the cells or as antigens for preparing antibodies against said proteins. The cDNAs can be utilized as probes for the gene diagnosis and gene sources for the gene therapy. Furthermore, the cDNAs can be utilized for large-scale expression of said proteins. Cells, wherein these membrane protein genes are introduced and membrane proteins are expressed in large amounts, can be utilized for detection of the corresponding ligands, screening of novel low-molecular pharmaceuticals, and so on.
摘要翻译：本发明提供具有跨膜结构域的人蛋白质和编码这些蛋白质的cDNA以及表达所述cDNA的真核细胞。所有蛋白质都存在于细胞膜中，因此被认为是控制细胞增殖和分化的蛋白质。因此，蛋白质可以用作药物，例如与控制细胞的增殖和分化有关的制癌剂，或作为用于制备针对所述蛋白质的抗体的抗原。 cDNA可用作基因诊断的探针和基因治疗的基因来源。此外，cDNA可用于大规模表达所述蛋白质。其中引入这些膜蛋白基因和大量表达膜蛋白的细胞可用于检测相应的配体，筛选新的低分子药物等。

2. 发明申请

US20040068104A1 Human galectin-9-like proteins and cDNAs encoding these proteins 审中-公开
标题翻译：人半乳凝素-9样蛋白和编码这些蛋白质的cDNA
公开(公告)号：US20040068104A1
公开(公告)日：2004-04-08
申请号：US10633035
申请日：2003-08-04
申请人： Sagami Chemical Research Center , Protegene Inc.
发明人： Seishi Kato , Tomoko Kimura , Shingo Sekine , Kouju Kamata
IPC分类号： C07H021/04 , C07K014/47
CPC分类号： C07K14/4726
摘要： Cloning of human cDNAs coding for galectin-9-like proteins, expression with Escherichia coli of proteins encoded by these human cDNAs, and determination of the lactose-binding activity of these expression products.
摘要翻译：克隆编码半乳凝素-9样蛋白的人cDNA，用这些人cDNA编码的蛋白质与大肠杆菌的表达，以及这些表达产物的乳糖结合活性的测定。

3. 发明申请

US20020106777A1 Human PEC-60-like protein and DNA encoding this protein 审中-公开
标题翻译：人类PEC-60样蛋白和编码该蛋白的DNA
公开(公告)号：US20020106777A1
公开(公告)日：2002-08-08
申请号：US09941309
申请日：2001-08-28
申请人： Sagami Chemical Research Center
发明人： Seishi Kato , Tomoko Yamaguchi , Shingo Sekine , Kouju Kamata
IPC分类号： C12N009/24 , C12N009/64 , C07H021/04
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human PEC-60-like protein, a gastrointestinal hormone excreted by a stomach tissue and a cDNA encoding this protein. The protein and the gene of the present invention can provide a protein containing the amino acid sequence represented by Sequence No. 1 and a t DNA encoding said protein exemplified as a cDNA containing the base sequence represented by Sequence No. 1. as well as a human cDNA encoding a human PEC-60-like protein and said protein by the expression of this human cDNA recombinant.
摘要翻译：本发明提供人类PEC-60样蛋白质，由胃组织排出的胃肠激素和编码该蛋白质的cDNA。本发明的蛋白质和基因可以提供含有序列号1所示的氨基酸序列的蛋白质和编码所述蛋白质的DNA，该DNA作为含有序列号1所示的碱基序列的cDNA，以及人通过该人cDNA重组体的表达，编码人类PEC-60样蛋白质的cDNA和所述蛋白质。

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