专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09546372B2 Regulatory elements and uses thereof 有权
标题翻译：调节元素及其用途
公开(公告)号：US09546372B2
公开(公告)日：2017-01-17
申请号：US13915522
申请日：2013-06-11
申请人： SYNTHETIC GENOMICS, INC.
发明人： Michele M. Champagne , Toby H. Richardson , Jun Urano
IPC分类号： C12N15/82 , C12N15/79
CPC分类号： C12N15/8216 , C07K14/405 , C12N15/79
摘要： The present application provides novel regulatory elements including promoter sequences from marine microorganisms. The application further discloses DNA constructs containing these novel regulatory elements; transgenic cells, transgenic non-human organisms, and progeny containing these novel regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements disclosed herein are particularly suited for use in Nannochloropsis and other microalgae.
摘要翻译：本申请提供了新的调控元件，包括来自海洋微生物的启动子序列。本申请进一步公开了含有这些新型调节元件的DNA构建体; 转基因细胞，转基因非人生物和含有这些新型调节元件的后代。还公开了修饰，制备和使用调节元件的方法。本文公开的调节元件特别适用于南非氯氰菊酯和其他微藻类。

2. 发明申请

US20140363892A1 REGULATORY ELEMENTS AND USES THEREOF 有权
标题翻译：法规要素及其用途
公开(公告)号：US20140363892A1
公开(公告)日：2014-12-11
申请号：US13915522
申请日：2013-06-11
申请人： SYNTHETIC GENOMICS, INC.
发明人： Michele M. Champagne , Toby H. Richardson , Jun Urano
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C07K14/405 , C12N15/79
摘要： The present application provides novel regulatory elements including promoter sequences from marine microorganisms. The application further discloses DNA constructs containing these novel regulatory elements; transgenic cells, transgenic non-human organisms, and progeny containing these novel regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements disclosed herein are particularly suited for use in Nannochloropsis and other microalgae.
摘要翻译：本申请提供了新的调控元件，包括来自海洋微生物的启动子序列。本申请进一步公开了含有这些新型调节元件的DNA构建体; 转基因细胞，转基因非人生物和含有这些新型调节元件的后代。还公开了修饰，制备和使用调节元件的方法。本文公开的调节元件特别适用于南非氯氰菊酯和其他微藻类。

3. 发明申请

US20180051280A1 MATERIALS AND METHODS FOR THE SYNTHESIS OF ERROR-MINIMIZED NUCLEIC ACID MOLECULES 审中-公开
公开(公告)号：US20180051280A1
公开(公告)日：2018-02-22
申请号：US15667515
申请日：2017-08-02
申请人： Synthetic Genomics, Inc.
发明人： Daniel G. Gibson , Nicky Caiazza , Toby H. Richardson
IPC分类号： C12N15/10 , C12N9/22 , C12P19/34 , C12Q1/68
摘要： The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity. The nucleic acid molecules are cut at the mismatch site or near the mismatch site, leaving a double-stranded nucleic acid molecule having a mismatch at the end or near end of the molecule. The nucleic acid molecule is then exposed to a molecule having unidirectional exonuclease activity to remove the mismatched nucleotide. The missing nucleotides can then be filled in by the action of, e.g., a molecule having DNA polymerase activity. The result is double-stranded nucleic acid molecules with a decreased frequency of nucleotide mismatches. Also provided are novel nucleic acid sequences encoding mismatch endonucleases, polypeptides encoded thereby, as well as nucleic acid constructs, transgenic cells, and various compositions thereof.

4. 发明授权

US09771576B2 Materials and methods for the synthesis of error-minimized nucleic acid molecules 有权
公开(公告)号：US09771576B2
公开(公告)日：2017-09-26
申请号：US13757633
申请日：2013-02-01
申请人： SYNTHETIC GENOMICS, INC.
发明人： Daniel G. Gibson , Nicky Caiazza , Toby H. Richardson
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/10 , C12N9/22
CPC分类号： C12N15/1093 , C07K2319/00 , C07K2319/036 , C07K2319/21 , C12N9/22 , C12P19/34 , C12Q1/6844 , C12Y301/11 , C12Y301/21 , C12Q2521/301 , C12Q2521/514
摘要： The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity. The nucleic acid molecules are cut at the mismatch site or near the mismatch site, leaving a double-stranded nucleic acid molecule having a mismatch at the end or near end of the molecule. The nucleic acid molecule is then exposed to a molecule having unidirectional exonuclease activity to remove the mismatched nucleotide. The missing nucleotides can then be filled in by the action of, e.g., a molecule having DNA polymerase activity. The result is double-stranded nucleic acid molecules with a decreased frequency of nucleotide mismatches. Also provided are novel nucleic acid sequences encoding mismatch endonucleases, polypeptides encoded thereby, as well as nucleic acid constructs, transgenic cells, and various compositions thereof.

5. 发明申请

US20130225451A1 MATERIALS AND METHODS FOR THE SYNTHESIS OF ERROR-MINIMIZED NUCLEIC ACID MOLECULES 有权
标题翻译：合成最小化核酸分子的材料与方法
公开(公告)号：US20130225451A1
公开(公告)日：2013-08-29
申请号：US13757633
申请日：2013-02-01
申请人： SYNTHETIC GENOMICS, INC.
发明人： Daniel G. Gibson , Nicky Caiazza , Toby H. Richardson
IPC分类号： C12N15/10 , C12N9/22
CPC分类号： C12N15/1093 , C07K2319/00 , C07K2319/036 , C07K2319/21 , C12N9/22 , C12P19/34 , C12Q1/6844 , C12Y301/11 , C12Y301/21 , C12Q2521/301 , C12Q2521/514
摘要： The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity. The nucleic acid molecules are cut at the mismatch site or near the mismatch site, leaving a double-stranded nucleic acid molecule having a mismatch at the end or near end of the molecule. The nucleic acid molecule is then exposed to a molecule having unidirectional exonuclease activity to remove the mismatched nucleotide. The missing nucleotides can then be filled in by the action of, e.g., a molecule having DNA polymerase activity. The result is double-stranded nucleic acid molecules with a decreased frequency of nucleotide mismatches. Also provided are novel nucleic acid sequences encoding mismatch endonucleases, polypeptides encoded thereby, as well as nucleic acid constructs, transgenic cells, and various compositions thereof.
摘要翻译：本发明提供了可用于核酸分子的纠错的材料和方法。在本发明的一个实施方案中，具有核苷酸错配的第一多个双链核酸分子通过暴露于具有单向错配核酸内切酶活性的分子而被片段化。在错配位点或错配位点附近切割核酸分子，留下在分子的末端或近端具有错配的双链核酸分子。然后将核酸分子暴露于具有单向外切核酸酶活性的分子以除去错配的核苷酸。然后可以通过例如具有DNA聚合酶活性的分子的作用填充缺失的核苷酸。结果是具有降低的核苷酸错配频率的双链核酸分子。还提供了编码错配核酸内切酶的新型核酸序列，由此编码的多肽，以及核酸构建体，转基因细胞及其各种组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式