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2. 发明授权

US10584134B2 Use of physiological cooling active ingredients, and agents containing such active ingredients 有权
公开(公告)号：US10584134B2
公开(公告)日：2020-03-10
申请号：US15629015
申请日：2017-06-21
申请人： SYMRISE AG , BASF SE
发明人： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC分类号： C07D495/20 , A23L27/20 , A23L33/10 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23G3/36 , A23G4/06 , A23L2/52 , A61K8/49 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61Q19/00 , A61Q17/04
摘要： The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

3. 发明授权

US11434220B2 Use of physiological cooling active ingredients, and compositions comprising such active ingredients 有权
公开(公告)号：US11434220B2
公开(公告)日：2022-09-06
申请号：US16642954
申请日：2018-08-31
申请人： BASF SE , SYMRISE AG
发明人： Benoît Join , Jekaterina Ongouta , Michael Backes , Rahim Brodhage , Arnold Machinek , Hubert Loges , Susanne Mundt , Tom Somers , Thomas Subkowski , Jens Wittenberg , Martin Weisel , Wolfgang Siegel , Claus Bollschweiler , Ralf Pelzer
IPC分类号： C07D317/46 , C07C323/41 , C07D405/12 , C07D213/75 , C07D231/40 , C07D407/12 , C07D307/14 , C07D409/12 , C07D409/14 , C07D405/14 , A61K8/49 , A61K8/46 , A61Q11/00 , A23L29/00 , A23L27/00 , A23G3/36
摘要： The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

4. 发明申请

US20150086491A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 审中-公开
标题翻译：使用生理冷却活性成分，以及含有此类活性成分的试剂
公开(公告)号：US20150086491A1
公开(公告)日：2015-03-26
申请号：US14533345
申请日：2014-11-05
申请人： SYMRISE AG , BASF SE
发明人： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC分类号： C07D495/20 , A61K31/4375 , C07D491/147 , A61K31/506 , A23L1/30 , A61K31/5377 , A61K8/49 , A61Q11/00 , A24B13/00 , A24D1/00 , A61K31/438 , C07D401/04
CPC分类号： C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
摘要： The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
摘要翻译：本发明涉及一种用于实现对皮肤或粘膜的冷却作用的TRPM8调节剂。

5. 发明申请

US20180093997A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 审中-公开
公开(公告)号：US20180093997A1
公开(公告)日：2018-04-05
申请号：US15629015
申请日：2017-06-21
申请人： SYMRISE AG , BASF SE
发明人： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC分类号： C07D495/20 , C07D491/147 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , A23L33/10 , A23L27/20 , D06M16/00 , D06M15/07 , D06M15/03 , C09D5/16 , C07D495/22 , C07D405/12 , C07D401/04 , C07D317/60 , C07D213/75 , C07C235/38 , C07C235/36 , C07C233/11
摘要： The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

6. 发明申请

US20160083328A1 PROCESS FOR CONTINUOUSLY PREPARING DI-C1-3-ALKYL SUCCINATES 有权
标题翻译：连续制备DI-C 3-烷基琥珀酸酯的方法
公开(公告)号：US20160083328A1
公开(公告)日：2016-03-24
申请号：US14888954
申请日：2014-05-07
申请人： BASF SE
发明人： Stefanie Demming , Suman Thotla , Jens Wittenberg , Gabriele Iffland , Till Christian Brueggemann , Yvonne Hoelzl , Wolfgang Siegel , Stephan Freyer
IPC分类号： C07C67/08 , B01D3/14 , C07C67/54
CPC分类号： C07C67/08 , B01D3/141 , C07C67/54 , C07C69/40
摘要： The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.
摘要翻译：本发明涉及一种连续制备二-C1-烷基琥珀酸盐的方法，该方法是在固定床非均相酸性酯化催化剂存在下，在管式反应器中在一定温度范围内使琥珀酸与C 1-3烷醇反应为60-100℃，其中在混合阶段中形成包含琥珀酸，C 1-3链烷醇，琥珀酸单C 1-3烷基酯，琥珀酸二-C 1-3烷基酯和水的混合物，进料到管式反应器的入口，并且其中管式反应器的出口流量的5％至75％作为循环物流直接循环到混合阶段，并且加入了C 3-链烷醇与琥珀酸的摩尔比并且在再循环流中不包括C 1-3链烷醇和琥珀酸，其浓度范围为2.0-9.5。本发明还涉及一种将琥珀酸酯化为C 3-链烷醇的反应器流出物分离以通过蒸馏得到二-C1-烷基琥珀酸酯的方法，其中分离是在分隔壁塔中进行的，其中在在柱的顶部萃取中除去C 1-3链烷醇和水，在柱的侧馏分中除去琥珀酸二-C1--3烷基酯，并且其中除去C 1 -C 3烷基琥珀酸酯和琥珀酸单在列的底部绘制。

7. 发明授权

US11044931B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof 有权
公开(公告)号：US11044931B2
公开(公告)日：2021-06-29
申请号：US16524437
申请日：2019-07-29
申请人： BASF SE
发明人： Thomas Subkowski , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel , Ralf Pelzer
IPC分类号： A23L27/20 , A61Q19/00 , A61K8/49 , C07J63/00 , C07C49/675 , A61K8/35 , A61K8/55 , C07D339/08 , C07D339/06 , C07D495/10 , C07D493/10 , C07D311/94 , C07D311/78 , C07D405/06 , C07D209/48 , C07D471/04 , C07D495/20 , C07D491/20 , C07F9/572 , A23L27/00 , C07J73/00 , C07J33/00 , C07C49/665 , C07J11/00
摘要： The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

8. 发明申请

US20170342015A1 PROCESS FOR CONTINUOUSLY PREPARING DI-C1-3-ALKYL SUCCINATES 审中-公开
公开(公告)号：US20170342015A1
公开(公告)日：2017-11-30
申请号：US15659058
申请日：2017-07-25
申请人： BASF SE
发明人： Stefanie Demming , Suman Thotla , Jens Wittenberg , Gabriele Iffland , Till Christian Brueggemann , Yvonne Hoelzl , Wolfgang Siegel , Stephan Freyer
IPC分类号： C07C67/08 , B01D3/14 , C07C67/54 , C07C69/40
CPC分类号： C07C67/08 , B01D3/141 , C07C67/54 , C07C69/40
摘要： The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.

9. 发明授权

US09738588B2 Process for continuously preparing di-C1-3-alkyl succinates 有权
公开(公告)号：US09738588B2
公开(公告)日：2017-08-22
申请号：US14888954
申请日：2014-05-07
申请人： BASF SE
发明人： Stefanie Demming , Suman Thotla , Jens Wittenberg , Gabriele Iffland , Christian Brueggemann , Yvonne Hoelzl , Wolfgang Siegel , Stephan Freyer
IPC分类号： C07C67/08 , B01D3/14 , C07C67/54
CPC分类号： C07C67/08 , B01D3/141 , C07C67/54 , C07C69/40
摘要： The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.

10. 发明授权

US10398159B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof 有权
公开(公告)号：US10398159B2
公开(公告)日：2019-09-03
申请号：US15610958
申请日：2017-06-01
申请人： BASF SE
发明人： Thomas Subkowski , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel , Ralf Pelzer
IPC分类号： A23L27/00 , A61K8/35 , A61K8/49 , A61K8/55 , A61Q19/00 , C07C49/665 , C07D209/48 , C07D311/78 , C07D311/94 , C07D339/06 , C07D339/08 , C07D405/06 , C07D471/04 , C07D491/20 , C07D493/10 , C07D495/10 , C07D495/20 , C07F9/572 , A23L27/20 , C07J63/00 , C07C49/675 , C07J33/00 , C07J73/00 , C07J11/00
摘要： The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

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