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1. 发明授权

US12061142B2 Method for determining physicochemical properties of nanoscale systems (NSS) 有权
公开(公告)号：US12061142B2
公开(公告)日：2024-08-13
申请号：US17310592
申请日：2020-02-05
申请人： SMARTDYELIVERY GMBH
发明人： Christoph Englert , Marc Lehmann , Ivo Nischang , Ulrich Schubert
IPC分类号： G01N15/04 , G01N11/00 , G01N33/543 , G01N15/00
CPC分类号： G01N15/042 , G01N11/00 , G01N2015/0038 , G01N2015/045
摘要： The invention relates to a method for determining the physicochemical properties of a nanoscale system (NSS) using analytical ultracentrifugation), comprising the steps of generating a multi-dimensional sedimentation analysis map associated with the NSS of interest; selecting sample-dependent parameters; determining sedimentation coefficient value/parameter in the sample; inserting sample sedimentation coefficient values onto the multi-dimensional sedimentation analysis map to obtain a NSS sample map value; and inferring from the NSS sample map value the physicochemical properties of the NSS sample. Furthermore, the invention relates to a system for performing the method, a computer program product and a computer readable storage medium.

2. 发明授权

US11344859B2 Reactor for the preparation of a formulation 有权
公开(公告)号：US11344859B2
公开(公告)日：2022-05-31
申请号：US16697454
申请日：2019-11-27
申请人： SmartDyeLivery GmbH
发明人： Christoph Englert , Marc Lehmann
IPC分类号： B01J19/18 , B01J19/00
摘要： The invention discloses a reactor for preparing a formulation. The reactor comprises at least two apertures, a base and at least one sidewall extending flush therefrom, wherein the base and the sidewall together define a mixing chamber with a height hM and at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall. A first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hA ranging from 0.6 to 0.0 hM in order to introduce free-flowing materials and/or mixtures to the mixing chamber. The first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but preventing outflow of free-flowing materials from the mixing chamber through the aperture. The first aperture is formed with an aperture area extending in a range between a minimum and a maximum, the minimum area being 0.05 mm2 and the maximum area being determined by a value resulting from Volumemixing chamber [cm3]/Areafirst aperture [cm2]≈5500.

3. 发明申请

US20210154639A1 Reactor for the preparation of a formulation 有权
公开(公告)号：US20210154639A1
公开(公告)日：2021-05-27
申请号：US16697454
申请日：2019-11-27
申请人： SmartDyeLivery GmbH
发明人： Christoph Englert , Marc Lehmann
IPC分类号： B01J19/18 , B01J19/00
摘要： The invention discloses a reactor for preparing a formulation. The reactor comprises at least two apertures, a base and at least one sidewall extending flush therefrom, wherein the base and the sidewall together define a mixing chamber with a height hM and at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall. A first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hA ranging from 0.6 to 0.0 hM in order to introduce free-flowing materials and/or mixtures to the mixing chamber. The first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but preventing outflow of free-flowing materials from the mixing chamber through the aperture. The first aperture is formed with an aperture area extending in a range between a minimum and a maximum, the minimum area being 0.05 mm2 and the maximum area being determined by a value resulting from Volumemixing chamber [cm3]/Areafirst aperture [cm2]≈5500.

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