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1. 发明申请

US20190056323A1 FLUORESCENCE DETECTION APPARATUS, ANALYSIS METHOD, AND FLUORESCENCE DETECTION SYSTEM 审中-公开
公开(公告)号：US20190056323A1
公开(公告)日：2019-02-21
申请号：US15770593
申请日：2016-11-04
申请人： SHISEIDO COMPANY, LTD. , KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
发明人： Masashi MITA , Eiichi NEGISHI , Kazuhiko Mibayashi , Kenji HAMASE
IPC分类号： G01N21/64 , G01N30/74 , G01N33/50 , G01N30/46
摘要： [Problem]To provide a fluorescence detection apparatus that is capable of simultaneously detecting a plurality of analyte components contained at different concentrations with a wide measurement range.[Solution]A fluorescence detection apparatus 100 includes a cell 110 into which an analyte of a sample is introduced, a light source 130 that irradiates excitation light on the analyte in the cell; a first detector 52 that detects fluorescence generated from the analyte after the excitation light has been irradiated on the analyte, and a second detector 53 that detects the fluorescence generated from the analyte after the excitation light has been irradiated on the analyte. The second detector detects the fluorescence with a measurement range that is different from the measurement range of the first detector, and the first detector and second detector detect the fluorescence simultaneously.

2. 发明申请

US20150065716A1 COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID 有权
标题翻译：化合物，光学解析方法和氨基酸的光学异构体的衍生物
公开(公告)号：US20150065716A1
公开(公告)日：2015-03-05
申请号：US14472920
申请日：2014-08-29
申请人： SHISEIDO COMPANY, LTD. , Kyushu University, National University Corporation
发明人： Masashi MITA , Kenji HAMASE , Tsubasa OYAMA
IPC分类号： C07D215/22 , C07C227/34 , C07D401/12
CPC分类号： C07C227/36 , C07C227/34 , C07D215/22 , C07D401/12 , C07C229/08
摘要： Disclosed is a compound represented by chemical formula (1): or chemical formula (2):
摘要翻译：公开了由化学式（1）表示的化合物：或化学式（2）：

3. 发明申请

US20150064797A1 METHOD FOR QUANTITATIVELY ANALYZING CYSTEINE AND CYSTINE AND REAGENT KIT FOR QUANTITATIVELY ANALYZING CYSTEINE AND CYSTINE 有权
标题翻译：用于定量分析CYSTEINE和CYSTINE和试剂盒的定量分析CYSTEINE和CYSTINE的方法
公开(公告)号：US20150064797A1
公开(公告)日：2015-03-05
申请号：US14472982
申请日：2014-08-29
申请人： SHISEIDO COMPANY, LTD. , KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
发明人： Masashi MITA , Kenji HAMASE
IPC分类号： G01N31/00
CPC分类号： G01N31/005 , G01N33/6815 , Y10T436/182
摘要： A method for quantitatively analyzing cysteine and cysteine includes a first step of adding a methyl-sulfurating agent to a sample that includes cysteine and cystine to obtain a methyl-sulfurated cysteine, a second step of adding a derivatizing agent to the methyl-sulfurated cysteine and the cystine to obtain a cysteine derivative and a cystine derivative, respectively, and a third step of quantifying the cysteine derivative and the cystine derivative.
摘要翻译：用于定量分析半胱氨酸和半胱氨酸的方法包括向包含半胱氨酸和胱氨酸的样品中加入甲基硫化剂以获得甲基 - 硫化半胱氨酸的第一步骤，向甲基 - 硫化半胱氨酸添加衍生化试剂的第二步骤和分别得到半胱氨酸衍生物和胱氨酸衍生物的胱氨酸，第三步是定量半胱氨酸衍生物和胱氨酸衍生物。

4. 发明申请

US20160313342A1 MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开
标题翻译：早期诊断KIDNEY失败的标记
公开(公告)号：US20160313342A1
公开(公告)日：2016-10-27
申请号：US15103539
申请日：2014-12-11
申请人： SHISEIDO COMPANY, LTD. , KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
发明人： Kenji Hamase , Yurika MIYOSHI , Masashi MITA
IPC分类号： G01N33/68
CPC分类号： G01N33/6812 , G01N2800/347
摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.
摘要翻译：本发明解决了鉴定肾衰竭的生物标志物的问题，所述生物标志物可从尿液或血液中获得，并且从早期阶段比肾小球滤过率和血清肌酐水平波动，从而开发用于诊断早期肾衰竭的技术。用于分析肾衰竭疑似受试者的血液，血浆，血清或尿液的方法包括测量一对D型和L型的至少一种氨基酸的浓度的步骤，所述氨基酸选自由以下组成的氨基酸组： [D-丝氨酸]和[L-丝氨酸]等，包含在受试者的血液，血浆，血清或尿液中，并计算作为受试者的病理学指标，D型浓度与 L型浓度或D-型浓度相对于D-型和L-型总浓度的百分比。

5. 发明申请

US20160039743A1 COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID 有权
公开(公告)号：US20160039743A1
公开(公告)日：2016-02-11
申请号：US14918743
申请日：2015-10-21
申请人： SHISEIDO COMPANY, LTD. , KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
发明人： Masashi MITA , Kenji HAMASE , Tsubasa OYAMA
IPC分类号： C07C227/36
CPC分类号： C07C227/36 , C07C227/34 , C07D215/22 , C07D401/12 , C07C229/08
摘要： Disclosed is a compound represented by chemical formula (1): or chemical formula (2):

6. 发明申请

US20180045690A1 CHIRAL ANALYSIS METHOD OF BOUND AMINO ACID AND CHIRAL ANALYSIS SYSTEM 审中-公开
公开(公告)号：US20180045690A1
公开(公告)日：2018-02-15
申请号：US15555862
申请日：2016-05-10
申请人： SHISEIDO COMPANY, LTD. , KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
发明人： Kenji HAMASE , Shoto ISHIGO , Yurika MIYOSHI , Tadashi UEDA , Masashi MITA
IPC分类号： G01N30/06 , G01N33/68 , G01N30/78 , G01N30/72 , G01N30/74
CPC分类号： G01N30/06 , G01N30/7233 , G01N30/74 , G01N30/78 , G01N30/8679 , G01N30/88 , G01N33/68 , G01N2030/067 , G01N2030/8818 , G01N2030/8877 , G01N2560/00
摘要： A chiral analysis method of a bound amino acid includes a step of hydrolyzing a bound amino acid using a deuterium chloride-deuterium oxide solution and/or deuterium oxide; a step of separating, by chiral separation, a D-form and an L-form of an amino acid generated by the hydrolyzation; a step of generating fragments from the separated amino acid; and a step of selecting and analyzing a predetermined fragment that contains an α carbon and does not contain a side chain from the generated fragments, by mass spectrometry.

7. 发明申请

US20190339282A1 MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开
公开(公告)号：US20190339282A1
公开(公告)日：2019-11-07
申请号：US16511097
申请日：2019-07-15
申请人： Shiseido Company, Ltd.
发明人： Kenji Hamase , Yurika MIYOSHI , Masashi MITA
IPC分类号： G01N33/68
摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

8. 发明申请

US20180252730A1 DISEASE-STATE BIOMARKER FOR RENAL DISEASE 审中-公开
公开(公告)号：US20180252730A1
公开(公告)日：2018-09-06
申请号：US15580855
申请日：2016-06-10
申请人： Kanazawa University , Shiseido Company. Ltd
发明人： Takashi Wada , Kengo FURUICHI , Norihiro SAKAI , Yasunori IWATA , Akinori HARA , Yusuke NAKADE , Kenji HAMASE , Yurika MIYOSHI , Maiko NAKANE , Masashi MITA
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6806 , G01N2800/347
摘要： The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

9. 发明申请

US20170192024A1 METHOD FOR PRETREATMENT AND METHOD FOR ANALYSIS OF LENALIDOMIDE IN BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：US20170192024A1
公开(公告)日：2017-07-06
申请号：US15312777
申请日：2015-05-21
申请人： Shiseido Company, Ltd
发明人： Yosuke TOJO , Masashi MITA , Wolfgang Lindner
IPC分类号： G01N33/94 , B01D15/12 , B01D15/26 , B01D15/16
摘要： The present invention addresses the problem of providing a novel method for the pretreatment of a biological sample containing lenalidomide enantiomer and thereby establishing a simple and accurate method for the quantitative analysis of lenalidomide enantiomer. In the present invention, the racemization and decomposition of lenalidomide enantiomer in a biological sample can be prevented by the deproteinization under acidic conditions of the biological sample containing lenalidomide enantiomer, and the lenalidomide enantiomer can be simply and accurately quantitatively analyzed by subjecting to HPLC the biological sample that has been pretreated in such a way.

10. 发明申请

US20190339281A1 MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开
公开(公告)号：US20190339281A1
公开(公告)日：2019-11-07
申请号：US16231381
申请日：2018-12-21
申请人： Shiseido Company, Ltd.
发明人： Kenji HAMASE , Yurika MIYOSHI , Masashi MITA
IPC分类号： G01N33/68
摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

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