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1. 发明申请

US20190038754A1 PHARMACEUTICAL COMPOSITION IN SOLID EXTRUDED FORM 审中-公开
公开(公告)号：US20190038754A1
公开(公告)日：2019-02-07
申请号：US16046488
申请日：2018-07-26
申请人： SE Tylose, USA, Inc. , Shin-Etsu Chemical Co., Ltd.
发明人： Jiannan Lu , Sakae Obara
IPC分类号： A61K47/38 , A61K31/496 , A61K31/4418 , A61K47/26
摘要： A pharmaceutical composition including an extruded solid and one or more pharmaceuticals or nutraceuticals is provided. The extruded solid includes hydroxypropylmethylcellulose acetate succinate and isomalt.

2. 发明申请

US20160136283A1 SOLUTION FOR SPRAY DRYING COMPRISING HYPROMELLOSE ACETATE SUCCINATE AND METHOD FOR PRODUCING SOLID DISPERSION 审中-公开
标题翻译：用于喷雾干燥的方法，其包含乙醇缩水甘油酯和生产固体分散体的方法
公开(公告)号：US20160136283A1
公开(公告)日：2016-05-19
申请号：US14939510
申请日：2015-11-12
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Shogo Warashina , Fumie Kusaki , Kazuki Kikuchi , Sakae Obara , Naosuke Maruyama
IPC分类号： A61K47/38 , A61K47/10 , A61K47/02 , A61K31/496 , A61K9/10
CPC分类号： A61K47/38 , A61K9/08 , A61K9/146 , A61K9/1652 , A61K31/496
摘要： There are provided a solution for spray drying having a high transmittance and markedly reduced generation of undissolved matter; and a method for producing a solid dispersion by using the solution for spray drying so that clogging with the undissolved matter is reduced and dissolution is improved. More specifically, there is provided a solution for spray drying comprising hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more, a solvent, and a drug. There is also provided a method for producing a solid dispersion comprising the step of removing the solvent from the spray drying solution.
摘要翻译：提供了具有高透射率并显着减少未溶解物质的产生的喷雾干燥的溶液; 以及通过使用喷雾干燥用溶液制造固体分散体的方法，从而降低了与未溶解物质的堵塞并提高了溶解度。更具体地，提供了包含羟丙氧基摩尔取代度为0.40以上的溶剂和药物的乙酸琥珀酸羟丙甲纤维素（HPMCAS）的喷雾干燥溶液。还提供了一种制备固体分散体的方法，其包括从喷雾干燥溶液中除去溶剂的步骤。

3. 发明授权

US11090295B2 Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate 有权
公开(公告)号：US11090295B2
公开(公告)日：2021-08-17
申请号：US14453935
申请日：2014-08-07
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Naosuke Maruyama , Shogo Warashina , Fumie Kusaki , Sakae Obara , Kazuki Kikuchi
IPC分类号： A61K31/4422 , A61K9/14 , A61K47/38 , A61K9/20
摘要： Provided are hypromellose acetate succinates (HPMCAS) for use as a hot-melt extrusion carrier having a volume average particle size (D50) of from 70 to 300 as measured by dry laser diffraction and a loose bulk density of from 0.25 to 0.40 g/cm3; and a hot-melt extrusion composition comprising the HPMCAS and a drug. Also provided is a method for producing a hot-melt extrudate including the steps of: hot-melting the hot-melt extrusion composition at a hot-melt temperature equal to or higher than a melting temperature of the HPMCAS, or at a hot-melt temperature equal to or higher than a temperature at which both of the HPMCAS and the drug become melt; and extruding the hot-melted composition.

4. 发明申请

US20150044289A1 HYPROMELLOSE ACETATE SUCCINATE FOR USE AS HOT-MELT EXTRUSION CARRIER, HOT-MELT EXTRUSION COMPOSITION, AND METHOD FOR PRODUCING HOT-MELT EXTRUDATE 审中-公开
标题翻译：用作高熔体挤出载体的丙烯酸乙酯酯，热熔融挤出组合物，以及用于生产高熔点挤出物的方法
公开(公告)号：US20150044289A1
公开(公告)日：2015-02-12
申请号：US14453935
申请日：2014-08-07
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Naosuke Maruyama , Shogo Warashina , Fumie Kusaki , Sakae Obara , Kazuki Kikuchi
IPC分类号： A61K31/4422 , A61K9/14
CPC分类号： A61K31/4422 , A61K9/146 , A61K9/20 , A61K47/38 , Y10T428/2982
摘要： Provided are hypromellose acetate succinates (HPMCAS) for use as a hot-melt extrusion carrier having a volume average particle size (D50) of from 70 to 300 as measured by dry laser diffraction and a loose bulk density of from 0.25 to 0.40 g/cm3; and a hot-melt extrusion composition comprising the HPMCAS and a drug. Also provided is a method for producing a hot-melt extrudate including the steps of: hot-melting the hot-melt extrusion composition at a hot-melt temperature equal to or higher than a melting temperature of the HPMCAS, or at a hot-melt temperature equal to or higher than a temperature at which both of the HPMCAS and the drug become melt; and extruding the hot-melted composition.
摘要翻译：提供了用作通过干激光衍射测量的体积平均粒径（D50）为70至300的热熔体挤出载体的乙酸纤维素乙酸酯琥珀酸酯（HPMCAS），以及0.25至0.40g / cm 3的松散堆积密度 ; 和包含HPMCAS和药物的热熔挤出组合物。还提供了一种生产热熔挤出物的方法，包括以下步骤：在等于或高于HPMCAS的熔融温度的热熔融温度下热熔融该热熔挤出组合物，或在热熔体温度等于或高于HPMCAS和药物两者融化的温度; 并挤出热熔融组合物。

5. 发明申请

US20200283655A1 COATING FORMULATION USING LOW-SUBSTITUTED CELLULOSE ETHER AND ITS PREPARATION 审中-公开
公开(公告)号：US20200283655A1
公开(公告)日：2020-09-10
申请号：US16775788
申请日：2020-01-29
申请人： SE Tylose USA, Inc. , Shin-Etsu Chemical Co., Ltd.
发明人： Sakae Obara , Anisul Quadir
IPC分类号： C09D101/28 , C08B11/20 , C09D7/63 , B05D3/12
摘要： A coating composition is provided. The coating composition includes a wet-milled product obtained by applying a shear force to an aqueous suspension of low-substituted cellulose ether having a molar substitution of from 0.05 to 1.0 per anhydrous glucose unit. The aqueous suspension of low-substituted cellulose ether is obtained by suspending and dispersing the low-substituted cellulose ether in water and a short chain alcohol.

6. 发明授权

US10016508B2 Composition for hot-melt extrusion and method for producing hot-melt extrusion product using same 有权
公开(公告)号：US10016508B2
公开(公告)日：2018-07-10
申请号：US14294258
申请日：2014-06-03
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Shogo Warashina , Fumie Kusaki , Kazuki Kikuchi , Sakae Obara , Naosuke Maruyama
IPC分类号： A61K31/4422 , A61K47/38 , C08B11/193 , C08B11/20 , C08B13/00 , C08L1/32 , A61K9/14 , C08J3/20 , A61K31/496
CPC分类号： A61K47/38 , A61K9/146 , A61K31/4422 , A61K31/496 , C08B11/193 , C08B11/20 , C08B13/00 , C08J3/201 , C08J2301/32 , C08L1/32
摘要： Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.

7. 发明申请

US20140357681A1 Composition for Hot-Melt Extrusion and Method for Producing Hot-Melt Extrusion Product Using Same 有权
标题翻译：用于热熔体挤出的组合物和使用它的热熔体挤出产物的生产方法
公开(公告)号：US20140357681A1
公开(公告)日：2014-12-04
申请号：US14294258
申请日：2014-06-03
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Shogo Warashina , Fumie Kusaki , Kazuki Kikuchi , Sakae Obara , Naosuke Maruyama
IPC分类号： A61K31/4422
CPC分类号： A61K47/38 , A61K9/146 , A61K31/4422 , A61K31/496 , C08B11/193 , C08B11/20 , C08B13/00 , C08J3/201 , C08J2301/32 , C08L1/32
摘要： Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.
摘要翻译：提供一种用于热熔挤出的组合物，其可以在比常规温度低的温度下进行热熔挤出，因此不导致药物的热诱导失活; 以及比喷雾干燥法简单的热熔挤出制品的制造方法。更具体地，提供了包含药物和乙氧基甲基纤维素乙酸琥珀酸酯（HPMCAS）的组合物，其具有0.40或更高的羟丙氧基摩尔取代度。本发明还提供一种热熔挤出产品的制造方法，其特征在于，包括将热熔融挤出用组合物热熔融挤出的步骤，所述组合物包括药物和醋酸羟丙甲纤维素琥珀酸酯，所述组合物的羟丙氧基摩尔取代度为0.40以上，或者在等于或高于乙酸琥珀酸羟丙甲纤维素和药物熔化的温度的热熔融温度下进行。

8. 发明申请

US20210113700A1 PHARMACEUTICAL COMPOSITION IN SOLID EXTRUDED FORM 有权
公开(公告)号：US20210113700A1
公开(公告)日：2021-04-22
申请号：US17134668
申请日：2020-12-28
申请人： SE Tylose USA, Inc. , Shin-Etsu Chemical Co., Ltd.
发明人： Jiannan Lu , Sakae Obara
IPC分类号： A61K47/38 , A61K47/26 , A61K31/4418 , A61K31/496
摘要： A pharmaceutical composition including an extruded solid and one or more pharmaceuticals or nutraceuticals is provided. The extruded solid includes hydroxypropylmethylcellulose acetate succinate and isomalt.

9. 发明授权

US10646573B2 Composition for hot melt extrusion and method for producing hot melt extrudate by using same 有权
公开(公告)号：US10646573B2
公开(公告)日：2020-05-12
申请号：US14892421
申请日：2014-06-03
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Shogo Warashina , Fumie Kusaki , Sakae Obara , Kazuki Kikuchi , Naosuke Maruyama
IPC分类号： A61K47/38 , A61K9/14 , A61K31/4422 , C08J3/20 , C08B11/193 , C08B11/20 , C08B13/00 , C08L1/32 , A61K31/496
摘要： Provided is a composition for hot melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6. Further, provided is a method for producing a hot melt extrudate including the step of hot melt-extruding a composition for hot melt extrusion including a drug and hypromellose acetate succinate having a molar hydroxypropoxy substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6, at a hot melt temperature of not lower than a melting temperature of the hypromellose acetate succinate or of not lower than a temperature at which both the hypromellose acetate succinate and the drug are melted.

10. 发明申请

US20160331689A1 AQUEOUS ENTERIC COATING COMPOSITION 审中-公开
标题翻译： AQUEOUS ENTERIC涂料组合物
公开(公告)号：US20160331689A1
公开(公告)日：2016-11-17
申请号：US15132627
申请日：2016-04-19
申请人： SE Tylose USA, Inc. , Shin-Etsu Chemical Co., Ltd.
发明人： Anisul Quadir , Sakae Obara
IPC分类号： A61K9/28 , A61K9/50
CPC分类号： A61K9/282 , A61K9/2866 , A61K9/5015 , A61K9/5042
摘要： An aqueous enteric coating composition including hydroxypropylmethylcellulose, acetate succinate, and a basic amino acid.
摘要翻译：包含羟丙基甲基纤维素，乙酸琥珀酸酯和碱性氨基酸的水性肠溶包衣组合物。

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