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1. 发明申请

US20140329255A1 METHODS OF SCREENING T1R1/T1R3 RECEPTORS FOR COMPOUNDS THAT MODULATE UMAMI TASTE SIGNALING 审中-公开
标题翻译：筛选用于调节UMAMI TASTE信号的化合物的T1R1 / T1R3受体的方法
公开(公告)号：US20140329255A1
公开(公告)日：2014-11-06
申请号：US14277525
申请日：2014-05-14
申请人： SENOMYX, INC.
发明人： Mark ZOLLER , Xiaodong LI , Lena STASZEWSKI , Shawn O'CONNELL , Sergey ZOZULYA , Jon Elliot ADLER , Hong XU , Fernando ECHEVERRI
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。

2. 发明申请

US20180088135A1 T2R Taste Receptors and Genes Encoding Same 审中-公开
公开(公告)号：US20180088135A1
公开(公告)日：2018-03-29
申请号：US15714224
申请日：2017-09-25
申请人： SENOMYX, INC
发明人： Jon Elliot ADLER
IPC分类号： G01N33/74 , G01N33/566 , G01N33/58 , C07K14/705 , C07H21/04
CPC分类号： G01N33/74 , A01K2217/05 , A61K38/00 , C07H21/04 , C07K14/705 , C07K2319/00 , G01N33/566 , G01N33/582 , G01N2333/726 , G01N2500/00 , G01N2500/04
摘要： Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.

3. 发明申请

US20160061847A1 T2R Taste Receptors and Genes Encoding Same 审中-公开
标题翻译： T2R口味受体和编码相同的基因
公开(公告)号：US20160061847A1
公开(公告)日：2016-03-03
申请号：US14850598
申请日：2015-09-10
申请人： Senomyx, Inc.
发明人： Jon Elliot ADLER
IPC分类号： G01N33/74 , C07K14/705 , G01N33/58
CPC分类号： G01N33/74 , A01K2217/05 , A61K38/00 , C07H21/04 , C07K14/705 , C07K2319/00 , G01N33/566 , G01N33/582 , G01N2333/726 , G01N2500/00 , G01N2500/04
摘要： Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体和编码所述受体的基因。具体地，描述被认为涉及苦味感觉的T2R味道G蛋白偶联受体以及编码它们的基因，以及用于分离这些基因并分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新分子或分子组合的方法，以及用于模拟一种或多种口味的方法。

4. 发明申请

US20190085051A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
公开(公告)号：US20190085051A1
公开(公告)日：2019-03-21
申请号：US16128633
申请日：2018-09-12
申请人： Senomyx , Inc.
发明人： Jon Elliot ADLER , Sergey ZOZULYA , Xiaodong LI , Shawn O'CONNELL , Lena LUUKKONEN
IPC分类号： C07K14/72 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are provided. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are provided, along with methods for isolating such genes and for isolating and expressing such receptors.

5. 发明申请

US20170313761A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
公开(公告)号：US20170313761A1
公开(公告)日：2017-11-02
申请号：US15483353
申请日：2017-04-10
申请人： Senomyx, Inc.
发明人： Jon Elliot ADLER , Sergey ZOZULYA , Xiaodong LI , Shawn O'CONNELL , Lena LUUKKONEN
IPC分类号： C07K14/72 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are provided. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are provided, along with methods for isolating such genes and for isolating and expressing such receptors.

6. 发明申请

US20150322132A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
标题翻译： T1R TASTE受体和编码它们的基因
公开(公告)号：US20150322132A1
公开(公告)日：2015-11-12
申请号：US14715168
申请日：2015-05-18
申请人： SENOMYX, INC.
发明人： Jon Elliot ADLER , Xiaodong Li , Lena Luukkonen , Shawn O'Connell , Sergey Zozulya
IPC分类号： C07K14/72 , G06F19/12 , C12Q1/68 , G01N33/50 , G01N33/74
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定味觉刺激的味觉感知的方法，以及用于产生哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

7. 发明申请

US20150299293A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
标题翻译： T1R TASTE受体和编码它们的基因
公开(公告)号：US20150299293A1
公开(公告)日：2015-10-22
申请号：US14696896
申请日：2015-04-27
申请人： Senomyx, Inc.
发明人： Jon Elliot ADLER , Sergey Zozulya , Xiaodong LI , Shawn O'CONNELL , Lena STASZEWSKI
IPC分类号： C07K14/72
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

8. 发明申请

US20180086815A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
公开(公告)号：US20180086815A1
公开(公告)日：2018-03-29
申请号：US15784352
申请日：2017-10-16
申请人： SENOMYX, INC.
发明人： Jon Elliot ADLER , Xiaodong LI , Lena LUUKKONEN , Shawn O'CONNELL , Sergey ZOZULYA
IPC分类号： C07K14/72 , C07K14/705 , G01N33/68 , C12Q1/68 , G01N33/50 , G06F19/12 , G01N33/74
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G16B5/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

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