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1. 发明申请

US20150031684A1 SWEET FLAVOR MODIFIER 有权
公开(公告)号：US20150031684A1
公开(公告)日：2015-01-29
申请号：US14449350
申请日：2014-08-01
申请人： SENOMYX, INC.
发明人： Catherine TACHDJIAN , Donald KARANEWSKY , Sara WERNER , Vincent DARMOHUSODO , Jeff YAMAMOTO
IPC分类号： A23L1/22 , C07D417/14 , C07D471/04 , C07D417/12
CPC分类号： C07D417/12 , A23L2/56 , A23L2/60 , A23L5/00 , A23L7/00 , A23L27/88 , A23L29/30 , A23L29/35 , A23V2002/00 , C07D417/14 , C07D471/04
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

2. 发明申请

US20180364220A1 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF 审中-公开
公开(公告)号：US20180364220A1
公开(公告)日：2018-12-20
申请号：US16114108
申请日：2018-08-27
申请人： Senomyx, Inc.
发明人： Catherine TACHDJIAN , Andrew P. PATRON , Sara L. ADAMSKI-WERNER , Farid BAKIR , Qing CHEN , Vincent DARMOHUSODO , Stephen Terrence HOBSON , Xiaodong LI , Ming QI , Daniel H. ROGERS , Marketa RINNOVA , Guy SERVANT , Xiao-Qing TANG , Mark ZOLLER , David WALLACE , Amy XING , Klaus GUBERNATOR
IPC分类号： G01N33/543 , A23L27/20 , C07D317/68 , A61K8/55 , A61K8/49 , A23L27/00 , G01N33/566 , C07C275/34 , C07D405/12 , A23L2/56 , C07C275/30 , G01N33/74 , A61K47/22 , G01N33/50 , C07C233/65 , C07D307/84 , C07F9/655 , A61K47/24 , C07C235/54
摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

3. 发明申请

US20150093339A1 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF 审中-公开
标题翻译：新鲜香精，调味剂，TASTANTS，增味剂，UMAMI或甜味剂，和/或增强剂及其用途
公开(公告)号：US20150093339A1
公开(公告)日：2015-04-02
申请号：US14509761
申请日：2014-10-08
申请人： SENOMYX, INC.
发明人： Catherine TACHDJIAN , Andrew P. PATRON , Sara L. ADAMSKI-WERNER , Farid BAKIR , Qing CHEN , Vincent DARMOHUSODO , Stephen Terrence HOBSON , Xiaodong LI , Ming QI , Daniel H. ROGERS , Marketa RINNOVA , Guy SERVANT , Xiao-Qing TANG , Mark ZOLLER , David WALLACE , Amy XING , Klaus GUBERNATOR
IPC分类号： A23L1/22 , C07D317/68 , A61K8/49 , C07D405/12 , A61K47/24 , A61K8/55 , C07F9/655 , A23L2/56 , A61K47/22
CPC分类号： G01N33/543 , A23L2/56 , A23L27/202 , A23L27/203 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K8/4973 , A61K8/55 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D307/84 , C07D317/68 , C07D405/12 , C07F9/65517 , G01N33/5041 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
摘要翻译：本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

4. 发明申请

US20150141527A1 SWEET FLAVOR MODIFIER 审中-公开
公开(公告)号：US20150141527A1
公开(公告)日：2015-05-21
申请号：US14337764
申请日：2014-07-22
申请人： SENOMYX, INC
发明人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy James DAVIS , Vincent DARMOHUSODO , Melissa WONG , Victor SELCHAU
IPC分类号： C07D405/12 , A23L1/236 , A61K47/22 , C07D215/42 , C07D401/12
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

5. 发明申请

US20140094453A1 SWEET FLAVOR MODIFIER 有权
标题翻译：甜味调味剂
公开(公告)号：US20140094453A1
公开(公告)日：2014-04-03
申请号：US14096531
申请日：2013-12-04
申请人： SENOMYX, INC.
发明人： Catherine TACHDJIAN , Donald KARANEWSKY , Sara WERNER , Vincent DARMOHUSODO , Jeff YAMAMOTO
IPC分类号： C07D417/14 , A23L1/236 , C07D417/12
CPC分类号： C07D417/12 , A23L2/56 , A23L2/60 , A23L5/00 , A23L7/00 , A23L27/88 , A23L29/30 , A23L29/35 , A23V2002/00 , C07D417/14 , C07D471/04
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.
摘要翻译：本发明包括具有结构式（I）的化合物或其盐或溶剂化物。这些化合物可用作甜味调味剂。本发明还包括包含本发明化合物的组合物和调节组合物甜味的方法。

6. 发明申请

US20160376263A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF 审中-公开
标题翻译：包括取代的1-苄氧基-3-（1-（异辛基-4-甲基苯基）-1H-吡唑-4-基）咪唑烷-2,4-二酮及其组合物的双酚类改性剂
公开(公告)号：US20160376263A1
公开(公告)日：2016-12-29
申请号：US15219573
申请日：2016-07-26
申请人： SENOMYX, INC.
发明人： Andrew PATRON , Catherine TACHDJIAN , Guy SERVANT , Tanya DITSCHUN
IPC分类号： C07D413/14 , A23L27/00 , A23L27/20 , A61K47/22
CPC分类号： C07D413/14 , A23L27/204 , A23L27/2054 , A23L27/2056 , A23L27/86 , A61K47/22
摘要： The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.
摘要翻译：本发明包括已知可以改变苦味感觉的化合物和组合物，以及所述组合物和化合物与另外的组合物，化合物和产品的组合。示例性组合物包含以下一种或多种：冷却剂; 非活性药物成分; 活性药物成分; 食品添加剂或食品; 调味剂或风味增强剂; 食品或饮料产品; 苦味化合物; 甜味剂苦涩酸味香料; 咸味香料; 鲜味香料; 植物或动物产品; 已知用于宠物护理产品的化合物; 已知用于个人护理产品的化合物; 已知用于家庭用品的化合物; 药物制剂; 局部制剂; 大麻衍生或大麻相关产品; 已知用于口腔护理产品的化合物; 饮料; 香水，香水或气味剂; 已知用于消费品的化合物; 有机硅化合物; 研磨剂表面活性剂升温剂; 吸烟用品; 脂肪，油或乳液; 和/或益生菌或补品。

7. 发明申请

US20140235623A1 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 审中-公开
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：US20140235623A1
公开(公告)日：2014-08-21
申请号：US14077749
申请日：2013-11-12
申请人： SENOMYX, INC.
发明人： Catherine TACHDJIAN , Donald S. KARANEWSKY , Xiao-Qing TANG , Xiaodong LI , Feng ZHANG , Guy SERVANT , Qing CHEN , Vincent DARMOHUSODO , Richard FINE , Joseph R. FOTSING , Jeffrey Robert HAMMAKER , Xinshan KANG , Rachel D.A. KIMMICH , Boris KLEBANSKY , Haitian LIU , Goran PETROVIC , Marketa RINNOVA , Sara ADAMSKI-WERNER , Jeffrey YAMAMOTO , Hong ZHANG , Albert ZLOTNIK
IPC分类号： C07D513/04 , C07D417/04 , A23L1/22 , A23L1/236 , A23L2/60 , A23L2/39 , C07D285/16 , C07D417/12
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
摘要翻译：本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体及其配体。本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄入组合物的甜味或治疗与化学感觉受体相关的病症的方法。此外，本发明包括制备化学感受器及其配体的改性剂的方法。

8. 发明申请

US20140128481A1 SWEET FLAVOR MODIFIER 有权
标题翻译：甜味调味剂
公开(公告)号：US20140128481A1
公开(公告)日：2014-05-08
申请号：US14061013
申请日：2013-10-23
申请人： SENOMYX, INC.
发明人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy DAVIS , Vincent DARMOHUSODO , Melissa WONG , Victor Selchau
IPC分类号： A23L1/22 , A61K47/22
CPC分类号： C07D495/04 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/54 , C07D215/60 , C07D401/12 , C07D405/12 , C07D471/04 , C07D491/048
摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
摘要翻译：本发明包括具有结构式（I）的化合物或其药学上可接受的盐，溶剂化物和/或酯。这些化合物可用作甜味调味剂。本发明还包括包含本发明化合物的组合物和增强可摄入组合物的甜味的方法。此外，本发明提供了制备化合物的方法。

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