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1. 发明授权

US10578628B2 Method for acquiring information on cause of prolongation of coagulation time, and device 有权
公开(公告)号：US10578628B2
公开(公告)日：2020-03-03
申请号：US15686976
申请日：2017-08-25
申请人： SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN , SYSMEX CORPORATION
发明人： Masahiro Ieko , Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki
IPC分类号： G01N33/86 , G01N33/49 , G01N35/02 , G01N21/82 , G16H50/20 , G01N21/27 , G01N21/51
摘要： The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.

2. 发明授权

US10132819B2 Method for measuring clotting time, measurement device for clotting time, and reagent kit 有权
公开(公告)号：US10132819B2
公开(公告)日：2018-11-20
申请号：US15219456
申请日：2016-07-26
申请人： SYSMEX CORPORATION , SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
IPC分类号： G01N33/86 , G01N33/48 , G01N21/82 , G01N33/49
摘要： Disclosed is a method for measuring a clotting time, including: a mixing step of mixing a blood sample, an activator, a phospholipid, and a manganese ion-forming compound to obtain a specimen; and a measurement step of mixing the specimen obtained in the mixing step with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen, wherein the blood sample is mixed with the manganese ion-forming compound separately from the activator and the phospholipid in the mixing step.

3. 发明授权

US10908170B2 Method for measuring clotting time, measurement device for clotting time, and reagent kit 有权
公开(公告)号：US10908170B2
公开(公告)日：2021-02-02
申请号：US15219846
申请日：2016-07-26
申请人： SYSMEX CORPORATION , SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
IPC分类号： G01N33/86
摘要： Disclosed is a method for measuring a clotting time, including the steps of: (A) mixing a blood sample, an activator, a phospholipid, and a nickel ion-forming compound to obtain a specimen; and (B) mixing the specimen obtained in step (A) with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen.

4. 发明授权

US09933443B2 Method, apparatus, and computer program for blood sample determination, and blood sample analyzer 有权
公开(公告)号：US09933443B2
公开(公告)日：2018-04-03
申请号：US15082170
申请日：2016-03-28
申请人： SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN , SYSMEX CORPORATION
发明人： Osamu Kumano , Naohiko Matsuo , Nobuo Arai , Masahiro Ieko
IPC分类号： G01N33/86 , G01N21/77 , G01N33/49 , G01N21/82 , G01N15/14 , G01N21/51
CPC分类号： G01N33/86 , G01N15/1456 , G01N21/51 , G01N21/77 , G01N21/82 , G01N33/4905 , G01N2015/1488 , G01N2021/825 , G01N2201/061
摘要： Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.

5. 发明授权

US09835635B2 Method for measuring clotting time, method for determining presence or absence of lupus anticoagulant, and reagent kit for detecting lupus anticoagulant 有权
公开(公告)号：US09835635B2
公开(公告)日：2017-12-05
申请号：US15082005
申请日：2016-03-28
申请人： SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN , SYSMEX CORPORATION
发明人： Osamu Kumano , Haruki Yamaguchi , Takeshi Suzuki , Masahiro Ieko
IPC分类号： G01N33/86 , G01N33/68 , G01N33/49 , G01N33/564 , G01N33/92 , G01N33/20
CPC分类号： G01N33/86 , G01N33/20 , G01N33/4905 , G01N33/564 , G01N33/6854 , G01N33/92 , G01N2800/224
摘要： Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.

6. 发明申请

US20140127725A1 METHOD FOR DETECTING LUPUS ANTICOAGULANTS 有权
标题翻译：检测LUPUS抗体的方法
公开(公告)号：US20140127725A1
公开(公告)日：2014-05-08
申请号：US14127026
申请日：2012-06-15
申请人： SEKISUI MEDICAL CO., LTD. , SCHOOL JURIDICAL PERSON HIGASHI- NIPPON-GAKUEN
发明人： Masahiro Ieko , Chizuru Morikawa
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , C12Q1/56 , G01N33/564 , G01N2800/104 , G01N2800/24
摘要： Provided is the development of a convenient LA detection method in which even a sample derived from a patient who receives anticoagulant therapy of warfarin, heparin or the like, is not affected by the anticoagulant therapy, discrimination from the deficiency of blood coagulation factors is enabled, and healthy person's plasma is not used. The method for detecting lupus anticoagulant includes the following steps (A), (B) and (C): (A) a step of adding a buffer solution composition containing blood coagulation factors to each of a blood sample and a diluted sample of the blood sample before measurement or at the time of measurement of the blood coagulation time; (B) a step of measuring the blood coagulation times for the various samples of step (A); and (C) a step of comparing the blood coagulation times for the various samples obtained in step (B).
摘要翻译：提供了一种方便的LA检测方法的开发，其中甚至来自接受华法林，肝素等的抗凝治疗的患者的样品不受抗凝血剂治疗的影响，能够区分血液凝固因子的不足，而不使用健康人的血浆。用于检测狼疮抗凝剂的方法包括以下步骤（A），（B）和（C）：（A）向血液样本和血液稀释样品中加入含有凝血因子的缓冲溶液组合物的步骤测量前或测定血液凝固时间时的样品; （B）测定步骤（A）的各种样品的凝血时间的步骤; 和（C）比较步骤（B）中获得的各种样品的凝血时间的步骤。

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