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1. 发明授权

US3499078A Everninomicin antibiotics and method for the manufacture thereof 失效
标题翻译：益生菌抗生素及其制备方法
公开(公告)号：US3499078A
公开(公告)日：1970-03-03
申请号：US3499078D
申请日：1968-09-25
申请人： SCHERING CORP
发明人： LUEDEMANN GEORGE M , WEINSTEIN MARVIN J
IPC分类号： A61K36/06 , C07H15/236 , C12P1/06 , C12P17/18 , C12P19/48 , A61K21/00 , C07G11/00 , C21D9/00
CPC分类号： C12R1/29 , C07H15/236 , C12P1/06 , C12P17/189 , C12P19/485 , Y10S435/863
摘要： Antibiotic No. 467 is produced by cultivating an antibiotic 467-producing strain of micromonospora halophytica var. nigra, especially NRRL 3097, or a 467-producing mutant thereof in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under aerobic conditions. Antibiotic No. 467 is found mainly in the clarified broth, from which it may be extracted at pH 2 to 9.5 with a water-immiscible organic solvent, e.g. ethylacetate. The solvent extract is concentrated and the antibiotic precipitated by a non-solvent such as hexane. Antibiotic 467 is insoluble in water, hexane and petroleum ether; soluble in ethyl acetate, methanol, butanol, benzene and ether; it is stable to acid and heat; contains C 60.73%, H 7.53%, N 3.70%, O 27.20%, Cl 0.04% and S 0.80%; U.V. 264 mm E1%=183 and 302 mm E1%=116 (inflection points); I.F. (Fig. 1); negative Ninhydrin and Sakaguchi tests; positive ferricyanide and reducing sugars; Rf values for various systems are specified; active against a wide range of gram-positive organisms. Paper chromatograms indicate the presence of various components of antibiotic No. 467. Therapeutic compositions comprise antibiotic No. 467, or a component thereof, and a carrier.
摘要翻译：抗生素号467是通过培养产生抗生素467的小孢子虫菌株变种产生的。黑质，特别是NRRL 3097，或其在含有营养培养基中的467产生突变体，其在需氧条件下含有可同化的碳和氮源。抗生素号467主要存在于澄清的肉汤中，可以用pH与水不混溶的有机溶剂例如pH 2至9.5进行萃取。乙酸乙酯。浓缩溶剂提取物，用非溶剂如己烷沉淀抗生素。抗生素467不溶于水，己烷和石油醚; 溶于乙酸乙酯，甲醇，丁醇，苯和乙醚; 对酸和热是稳定的; 含C 60.73％，H 7.53％，N 3.70％，O 27.20％，Cl 0.04％和S 0.80％; U.V. 264毫米E1％= 183和302毫米E1％= 116（拐点）; 如果。（图。1）; 负Ninhydrin和Sakaguchi测试; 正铁氰化物和还原糖; 指定各种系统的Rf值; 活跃于广泛的革兰氏阳性生物。纸张色谱图表明抗生素编号467的各种组分的存在。治疗组合物包含抗生素No.467或其组分和载体。

2. 发明授权

US3454696A Antibiotics 460 and methods for their production 失效
标题翻译：抗生素460及其生产方法
公开(公告)号：US3454696A
公开(公告)日：1969-07-08
申请号：US3454696D
申请日：1968-02-19
申请人： SCHERING CORP
发明人： WEINSTEIN MARVIN J , LUEDEMANN GEORGE M , WAGMAN GERALD H , MARQUEZ JOSEPH A
IPC分类号： A61K35/66 , A61K21/00 , C12K1/00
CPC分类号： C12P1/06 , C07G11/00 , C12R1/30 , Y10S435/864

3. 发明授权

US3091572A Gentamycin and method of production 失效
标题翻译：庆大霉素和生产方法
公开(公告)号：US3091572A
公开(公告)日：1963-05-28
申请号：US21115362
申请日：1962-07-16
申请人： SCHERING CORP
发明人： LUEDEMANN GEORGE M , WEINSTEIN MARVIN J
IPC分类号： C07H15/236
CPC分类号： C07H15/236 , Y10S435/863 , Y10S435/865

4. 发明授权

US3907771A Antibiotic 66-40 失效
标题翻译：抗生素66-40
公开(公告)号：US3907771A
公开(公告)日：1975-09-23
申请号：US37306473
申请日：1973-06-25
申请人： SCHERING CORP
发明人： WEINSTEIN MARVIN J , LUEDEMANN GEORGE M , WAGMAN GERALD H
IPC分类号： C07H15/22 , C07C47/18
CPC分类号： C07H15/22 , Y10S435/863 , Y10S514/969
摘要： Antibiotic 66-40, a new broad spectrum antibiotic having an adverse effect upon the growth of gram-positive and gram-negative bacteria, is described together with its method of production via the fermentation of Micromonospora inyoensis, a new species of Micromonospora.
摘要翻译：抗生素66-40是一种对革兰氏阳性菌和革兰氏阴性细菌生长有不利影响的新型广谱抗生素，其生产方法通过Micromonospora inyoensis（一种新型小单孢菌）的发酵进行了描述。

5. 发明授权

US3632750A Megalomicin and methods for production thereof 失效
标题翻译： MEGALOMICIN及其生产方法
公开(公告)号：US3632750A
公开(公告)日：1972-01-04
申请号：US3632750D
申请日：1969-09-04
申请人： SCHERING CORP
发明人： WEINSTEIN MARVIN J , LUEDEMANN GEORGE M , WAGMAN GERALD H , MARQUEZ JOSEPH A
IPC分类号： C07H17/08 , A61K21/00
CPC分类号： A61K31/70 , C07H17/08 , Y10S435/863
摘要： A NEW ANTIBIOTIC COMPLEX IDENTIFIED LAS ANTIBOTIC W847 COMPLEX (OR ANTIBIOTIC W847 OR MEGALOMICIN), COMPOSED OF AT LEAST FOUR MAJOR ANTIBIOTIC COMPONENTS IS PRODUCED BY THE CULTIVATION UNDER SUBMERGED AREOBIC CONDITIONS OF MICROMONOSPORA MEGALOMICEA, A HIHERTO UNDESCRIBED SPECIES OF THE GENUS MICROMONOSPORA OF THE ORDER ACTINOMYCETALES. THE INDIVIDUAL COMPONENTS ARE ISOLATED BY SOLVENT EXTRACTION AND CHROMATOGRAPHY AND ARE CHARACTERIZED BY THEIR RESPECTIVE CHEMICAL AND BIOLOGICAL PROPERTIES.

6. 发明授权

US3511909A Antibiotic halomicin 失效
标题翻译：抗生素HALOMICIN
公开(公告)号：US3511909A
公开(公告)日：1970-05-12
申请号：US3511909D
申请日：1968-10-21
申请人： SCHERING CORP
发明人： LUEDEMANN GEORGE M , WEINSTEIN MARVIN J
IPC分类号： A61K36/06 , C07H15/236 , C12P1/06 , C12P17/18 , C12P19/48 , A61K21/00
CPC分类号： C12R1/29 , C07H15/236 , C12P1/06 , C12P17/189 , C12P19/485 , Y10S435/863
摘要： Antibiotic No. 467 is produced by cultivating an antibiotic 467-producing strain of micromonospora halophytica var. nigra, especially NRRL 3097, or a 467-producing mutant thereof in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under aerobic conditions. Antibiotic No. 467 is found mainly in the clarified broth, from which it may be extracted at pH 2 to 9.5 with a water-immiscible organic solvent, e.g. ethylacetate. The solvent extract is concentrated and the antibiotic precipitated by a non-solvent such as hexane. Antibiotic 467 is insoluble in water, hexane and petroleum ether; soluble in ethyl acetate, methanol, butanol, benzene and ether; it is stable to acid and heat; contains C 60.73%, H 7.53%, N 3.70%, O 27.20%, Cl 0.04% and S 0.80%; U.V. 264 mm E1%=183 and 302 mm E1%=116 (inflection points); I.F. (Fig. 1); negative Ninhydrin and Sakaguchi tests; positive ferricyanide and reducing sugars; Rf values for various systems are specified; active against a wide range of gram-positive organisms. Paper chromatograms indicate the presence of various components of antibiotic No. 467. Therapeutic compositions comprise antibiotic No. 467, or a component thereof, and a carrier.
摘要翻译：抗生素号467是通过培养产生抗生素467的小孢子虫菌株变种产生的。黑质，特别是NRRL 3097，或其在含有营养培养基中的467产生突变体，其在需氧条件下含有可同化碳源和氮源。抗生素号467主要存在于澄清的肉汤中，可以用pH与水不混溶的有机溶剂例如pH 2至9.5进行萃取。乙酸乙酯。浓缩溶剂提取物，用非溶剂如己烷沉淀抗生素。抗生素467不溶于水，己烷和石油醚; 溶于乙酸乙酯，甲醇，丁醇，苯和乙醚; 对酸和热是稳定的; 含C 60.73％，H 7.53％，N 3.70％，O 27.20％，Cl 0.04％和S 0.80％; U.V. 264毫米E1％= 183和302毫米E1％= 116（拐点）; 如果。（图。1）; 负Ninhydrin和Sakaguchi测试; 正铁氰化物和还原糖; 指定各种系统的Rf值; 活跃于广泛的革兰氏阳性生物。纸张色谱图表明抗生素编号467的各种组分的存在。治疗组合物包含抗生素No.467或其组分和载体。

7. 发明授权

US3458626A Antibiotics 15 and methods for their production 失效
标题翻译：抗生素15及其生产方法
公开(公告)号：US3458626A
公开(公告)日：1969-07-29
申请号：US3458626D
申请日：1968-02-26
申请人： SCHERING CORP
发明人： WEINSTEIN MARVIN J , LUEDEMANN GEORGE M , WAGMAN GERALD H
IPC分类号： A61K21/00
CPC分类号： A61K36/06 , Y10S435/886

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