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1. 发明申请

US20230039492A1 DETECTION UNITS AND METHODS FOR DETECTING A TARGET ANALYTE 有权
公开(公告)号：US20230039492A1
公开(公告)日：2023-02-09
申请号：US17973055
申请日：2022-10-25
申请人： Scanogen Inc.
发明人： Alfredo Andres Celedon , Saravana Radha Krishna Murthy , Zhiguang Xu , Danielle Elise Schultz , Troy Allen Horn
IPC分类号： C12Q1/6816 , G01N33/543 , G01N27/327 , G01N27/74 , G01N27/414
摘要： The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.

2. 发明授权

US11360296B2 Imaging system 有权
公开(公告)号：US11360296B2
公开(公告)日：2022-06-14
申请号：US17013343
申请日：2020-09-04
申请人： SCANOGEN INC.
发明人： Zhiguang Xu , Alfredo Andres Celedon
IPC分类号： G02B21/36 , G02B21/06 , G01B9/04 , G02B21/16
摘要： An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.

3. 发明申请

US20190112641A1 DETECTION UNITS AND METHODS FOR DETECTING A TARGET ANALYTE 审中-公开
公开(公告)号：US20190112641A1
公开(公告)日：2019-04-18
申请号：US16217253
申请日：2018-12-12
申请人： Scanogen Inc.
发明人： Alfredo Andres Celedon , Saravana Radha Krishna Murthy , Zhiguang Xu , Danielle Elise Schultz , Troy Allen Horn
IPC分类号： C12Q1/6816 , G01N33/543
摘要： The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.

4. 发明申请

US20170363851A1 IMAGING SYSTEM 审中-公开
公开(公告)号：US20170363851A1
公开(公告)日：2017-12-21
申请号：US15444462
申请日：2017-02-28
申请人： Scanogen Inc.
发明人： Zhiguang Xu , Alfredo Andres Celedon
IPC分类号： G02B21/36 , G02B21/06 , G01B9/04
摘要： An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.

5. 发明授权

US11505818B2 Detection units and methods for detecting a target analyte 有权
公开(公告)号：US11505818B2
公开(公告)日：2022-11-22
申请号：US16217253
申请日：2018-12-12
申请人： Scanogen Inc.
发明人： Alfredo Andres Celedon , Saravana Radha Krishna Murthy , Zhiguang Xu , Danielle Elise Schultz , Troy Allen Horn
IPC分类号： C07K16/00 , C07H21/02 , C12Q1/6816 , G01N33/543 , G01N27/327 , G01N27/74 , G01N27/414
摘要： The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.

6. 发明申请

US20160258003A1 DETECTION UNITS AND METHODS FOR DETECTING A TARGET ANALYTE 审中-公开
标题翻译：用于检测目标分析的检测单位和方法
公开(公告)号：US20160258003A1
公开(公告)日：2016-09-08
申请号：US15033629
申请日：2015-02-05
申请人： SCANOGEN INC.
发明人： Alfredo Andres Celedon , Saravana Radha Krishna Murthy , Zhiguang Xu , Danielle Elise Schultz , Troy Allen Horn
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , G01N33/54306 , G01N33/54313 , G01N33/54373
摘要： The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.
摘要翻译：本申请涉及用于使用由靶和第一和第二探针形成的复合物检测样品中的一种或多种靶分析物的检测单元和方法，其中所述复合物包括细长区域，耦合到第一探针的颗粒，以及耦合到第二探针的固体支持物。目标分析物的特异性结合可以通过测量颗粒的位移来区别于颗粒的非特异性结合。

7. 发明授权

US11860354B2 Imaging system 有权
公开(公告)号：US11860354B2
公开(公告)日：2024-01-02
申请号：US17743166
申请日：2022-05-12
申请人： SCANOGEN INC.
发明人： Zhiguang Xu , Alfredo Andres Celedon
IPC分类号： G02B21/36 , G02B21/06 , G01B9/04 , G02B21/16
CPC分类号： G02B21/361 , G01B9/04 , G02B21/06 , G02B21/16 , G02B21/365
摘要： An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.

8. 发明授权

US10768406B2 Imaging system 有权
公开(公告)号：US10768406B2
公开(公告)日：2020-09-08
申请号：US15444462
申请日：2017-02-28
申请人： Scanogen Inc.
发明人： Zhiguang Xu , Alfredo Andres Celedon
IPC分类号： G02B21/36 , G02B21/06 , G01B9/04 , G02B21/16
摘要： An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.

9. 发明授权

US10179930B2 Detection units and methods for detecting a target analyte 有权
公开(公告)号：US10179930B2
公开(公告)日：2019-01-15
申请号：US15033629
申请日：2015-02-05
申请人： Scanogen Inc.
发明人： Alfredo Andres Celedon , Saravana Radha Krishna Murthy , Zhiguang Xu , Danielle Elise Schultz , Troy Allen Horn
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/6816 , G01N33/543
摘要： The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.

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