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    • 2. 发明申请
    • Lipopeptide Compounds and Their Use
    • 脂肽化合物及其用途
    • US20110224129A1
    • 2011-09-15
    • US13128661
    • 2009-11-24
    • Rustum S. BoyceJoseph CherianCleofe CalanasanMuhammad Sofian Asi Sihombing
    • Rustum S. BoyceJoseph CherianCleofe CalanasanMuhammad Sofian Asi Sihombing
    • A61K38/12C07K7/60A61P31/04
    • C07K7/56A61K38/00
    • The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.
    • 本发明一般涉及治疗化合物领域,更具体地涉及包含带有脂质侧链的环状肽(为方便起见,统称为“LP化合物”)的某些脂肽化合物,其特别是抗微生物剂 ,特别是抗菌。 本发明还涉及包含这种化合物的药物组合物,以及这些化合物和组合物在体外和体内的用途,以提供抗微生物功能,特别是抗菌功能,以及用于治疗介导的疾病和病症 特别是通过抗微生物功能改善的微生物,特别是细菌,特别是抗菌功能,包括细菌疾病,任选地与另一种试剂,例如另一种抗菌剂组合。