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1. 发明授权

US09913926B2 Adhesive complex coacervates and method of making and using thereof 有权
公开(公告)号：US09913926B2
公开(公告)日：2018-03-13
申请号：US13617882
申请日：2012-09-14
申请人： Russell J. Stewart , Hui Shao
发明人： Russell J. Stewart , Hui Shao
IPC分类号： A61L24/00 , A61F2/28 , C08L33/26 , A61L24/04 , A61L27/26 , A61L27/54 , C09J133/14 , C09D133/26 , C08F8/00 , C08F8/06 , C08F8/10
CPC分类号： A61L24/0073 , A61F2/2846 , A61L24/0015 , A61L24/043 , A61L27/26 , A61L27/54 , A61L2300/602 , A61L2300/62 , C08F8/00 , C08F8/06 , C08F8/10 , C08F2800/10 , C08F2810/20 , C08F2810/30 , C08L33/26 , C09D133/26 , C09J133/14 , C08F230/02 , C08F220/54 , C08F220/56
摘要： Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

2. 发明申请

US20140220082A1 ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：粘合复合物及其制备和使用方法
公开(公告)号：US20140220082A1
公开(公告)日：2014-08-07
申请号：US14128656
申请日：2012-06-27
申请人： Russell J. Stewart
发明人： Russell J. Stewart
IPC分类号： A61K47/32 , A61L24/06
CPC分类号： A61K47/32 , A61L24/0015 , A61L24/043 , A61L24/06 , A61L2300/62 , C08F220/10 , C08L43/02 , C08L2312/00 , C09J4/06 , C09J105/00 , C09J133/14 , C09J133/26 , C09J143/02 , C09J189/005
摘要： Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are produced by reacting (a) at least one poly anion comprising a plurality of activated ester groups, and (b) at least one polycation comprising a plurality of nucleophilic groups, wherein the nucleophilic groups react with the activated ester groups to produce a new oovalent bond between the polycation and the polyanion. The adhesive complex coacervates described herein have low interfacial tension with water and wettable substrates. When applied to a wet substrate they spread over the interface rather than beading up. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in wet or underwater applications and situations where water is present such as, for example, physiological conditions.
摘要翻译：本文描述了粘合剂复合凝聚层的合成及其用途。通过使（a）至少一种包含多个活化酯基的多阴离子和（b）至少一个包含多个亲核基团的聚阳离子反应，生成粘合剂复合物凝聚层，其中亲核基团与活化的酯基团反应，在聚阳离子和聚阴离子之间产生新的高价键。本文所述的粘合剂复合凝聚层具有与水和可湿性基材的低界面张力。当应用于湿底物时，它们分散在界面上而不是着色。粘合剂复合物凝聚层具有许多生物应用作为生物粘合剂和药物递送装置。特别地，本文所述的粘合剂复合物凝聚层在湿或水下应用和存在水的情况下特别有用，例如生理条件。

3. 发明申请

US20130189313A1 ADHESIVE COMPLEX COACERVATES AND METHOD OF MAKING AND USING THEREOF 有权
标题翻译：粘合复合材料及其制备和使用方法
公开(公告)号：US20130189313A1
公开(公告)日：2013-07-25
申请号：US13617882
申请日：2012-09-14
申请人： Russell J. Stewart , Hui Shao
发明人： Russell J. Stewart , Hui Shao
IPC分类号： A61L24/00 , A61F2/28 , C08L33/26
CPC分类号： A61L24/0073 , A61F2/2846 , A61L24/0015 , A61L24/043 , A61L27/26 , A61L27/54 , A61L2300/602 , A61L2300/62 , C08F8/00 , C08F8/06 , C08F8/10 , C08F2800/10 , C08F2810/20 , C08F2810/30 , C08L33/26 , C09D133/26 , C09J133/14 , C08F230/02 , C08F220/54 , C08F220/56
摘要： Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.
摘要翻译：本文描述了粘合剂复合凝聚层的合成及其用途。粘合剂复合凝聚层由一种或多种聚阳离子和一种或多种聚阴离子的混合物组成。粘合剂复合凝聚层中的聚阳离子和聚阴离子在固化时通过共价键彼此交联。当与常规生物粘合剂相比时，粘合剂复合凝聚层具有几个期望的特征，其在水基应用中是有效的。本文所述的粘合剂复合物凝聚层在施加到基底上时表现出良好的水中的界面张力（即，它们在界面上分布而不是串珠化）。另外，复合凝聚层分子间交联的能力增加了粘合剂复合物凝聚层的内聚强度。它们具有许多生物应用作为生物粘合剂和药物递送装置，并且在水下应用和存在水的情况下特别有用，例如生理条件。

4. 发明申请

US20130129787A1 ADHESIVE COMPLEX COACERVATES PRODUCED FROM ELECTROSTATICALLY ASSOCIATED BLOCK COPOLYMERS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：由静电相容的嵌段共聚物生产的粘合剂复合物及其制备和使用方法
公开(公告)号：US20130129787A1
公开(公告)日：2013-05-23
申请号：US13580794
申请日：2011-02-25
申请人： Russell J. Stewart
发明人： Russell J. Stewart
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K9/0048 , A61K31/661 , A61K47/46 , A61L24/0005 , A61L24/0015 , A61L24/046 , A61L2300/102 , A61L2300/62 , D01D5/06 , D01F6/44 , Y10T428/249921 , C08L77/04
摘要： Described herein is the synthesis of adhesive complex coacervates from electrostatically associated block copolymers, wherein the block copolymers comprise alternating polycationic and polyanionic blocks. Methods for making and the using the adhesive complex coacervates are also described herein.
摘要翻译：这里描述的是从静电相关的嵌段共聚物合成粘合剂复合凝聚层，其中嵌段共聚物包含交替的聚阳离子和聚阴离子嵌段。本文还描述了制备和使用粘合剂复合凝聚层的方法。

5. 发明授权

US5830659A Active microtubule-based separations by kinesins 失效
标题翻译：基于活性微管的驱动蛋白分离
公开(公告)号：US5830659A
公开(公告)日：1998-11-03
申请号：US713815
申请日：1996-09-13
申请人： Russell J. Stewart
发明人： Russell J. Stewart
IPC分类号： C12M1/40 , C12Q1/34 , C12Q1/68 , G01N33/566
CPC分类号： C07K1/22 , C12Q1/6806 , C12Q1/6816 , G01N2333/4712 , Y10S435/803 , Y10S435/814 , Y10S435/82
摘要： A method and system for separating a selected molecule from a heterogeneous mixture of molecules in aqueous solution are described. The method comprises (a) providing a separation device comprising a loading reservoir and a receiving reservoir coupled by a channel bearing immobilized microtubules aligned parallel to the longitudinal axis thereof the channel; (b) placing an aqueous solution containing the heterogeneous mixture of molecules in the loading reservoir; (c) adding a motor-ligand composition and ATP to the aqueous solution, wherein the motor-ligand composition comprises a motor protein for attaching to microtubules and moving therealong in the presence of ATP and the ligand is capable of binding the selected molecule, such that the ligand binds the selected molecule to form a complex and the complex moves along the immobilized microtubules to the receiving reservoir; and (d) removing the selected molecule from the receiving chamber.
摘要翻译：描述了一种用于在水溶液中从分子的非均匀混合物中分离所选择的分子的方法和系统。该方法包括（a）提供一种分离装置，该分离装置包括一个装载储存器和一个通过支承固定微管的通道连接的容纳储存器，固定的微管平行于其纵向轴线排列; （b）将含有分子的非均相混合物的水溶液放置在装载储存器中; （c）向水溶液中加入马达 - 配体组合物和ATP，其中马达 - 配体组合物包含用于附着于微管并在ATP存在下在其上移动的运动蛋白，并且配体能够结合所选择的分子，例如配体结合所选择的分子以形成复合物，并且复合物沿着固定的微管移动到接收储器; 和（d）从接收室中除去所选择的分子。

6. 发明授权

US09173971B2 Simple adhesive coacervates and methods of making and using thereof 有权
公开(公告)号：US09173971B2
公开(公告)日：2015-11-03
申请号：US13295061
申请日：2011-11-12
申请人： Russell J. Stewart
发明人： Russell J. Stewart
IPC分类号： A61L24/00
摘要： Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications.

7. 发明申请

US20100248389A1 ELECTROCHEMICAL DEPOSITION OF POLYMERS ON METAL SUBSTRATES 审中-公开
标题翻译：聚合物在金属基材上的电化学沉积
公开(公告)号：US20100248389A1
公开(公告)日：2010-09-30
申请号：US12679050
申请日：2008-09-22
申请人： Russell J. Stewart , Betsy J. Endrizzi , Gang Huang , Vladimir Hlady , Samuel Aaron Poff , Jennifer Schumaker-Parry
发明人： Russell J. Stewart , Betsy J. Endrizzi , Gang Huang , Vladimir Hlady , Samuel Aaron Poff , Jennifer Schumaker-Parry
IPC分类号： G01N33/53 , C25D11/00
CPC分类号： C08F2/58 , C09D5/4411 , C09D133/26
摘要： Described herein are methods for electrodepositing a variety of different polymers on metal substrates. The polymers are strongly adhered to the substrates. The substrates produced herein can be used in a number of different applications such as, for example, medical devices and biosensors. For example, the biosensors can be composed of one or more electrodes, where the electrodes have the same or different polymers electrochemically deposited on them. Finally, the methods described herein permit the evaluation of the electrodeposition process as well as monitor the ability of biomolecules to bind to the electrodeposited polymers.
摘要翻译：这里描述的是在金属基底上电沉积各种不同的聚合物的方法。聚合物牢固地附着在基材上。本文生产的基材可用于许多不同的应用，例如医疗装置和生物传感器。例如，生物传感器可以由一个或多个电极组成，其中电极具有电化学沉积在其上的相同或不同的聚合物。最后，本文描述的方法允许电沉积过程的评估以及监测生物分子与电沉积聚合物结合的能力。

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