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1. 发明授权

US6158363A Apparatus for dispensing particles 有权
标题翻译：用于分配颗粒的装置
公开(公告)号：US6158363A
公开(公告)日：2000-12-12
申请号：US455153
申请日：1999-12-06
申请人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
发明人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
IPC分类号： A01C7/08 , A01C7/10 , G01F1/708 , G01F1/00 , A01C7/20
CPC分类号： A01C7/081 , A01C7/102 , A01C7/105 , G01F1/7086 , Y02P60/16
摘要： An air seeder for planting agricultural crops includes: a storage tank for containing particles to be dispensed; a metering mechanism for transferring particles from the storage tank; an air distribution system for receiving particles from the metering mechanism, the air distribution system comprising a bank of tubes for transporting particles in a flow of air having a flow rate, and a damper mechanism at the bank of tubes for selective control of the flow rate within the bank of tubes; an air flow source for providing a flow of air to the bank of tubes; a particle velocity sensor located at each tube for providing a sensor output signal corresponding to a measured particle velocity; and a control mechanism operably connected to the sensors and to the damper mechanism for selective adjustment of the flow rate in the bank of tubes, the control mechanism being adapted to receive the sensor output signals, normalize the values corresponding to the sensor output signals, and display the normalized values.
摘要翻译：用于种植农作物的播种机包括：用于容纳要分配的颗粒的储罐; 用于从储罐转移颗粒的计量机构; 用于从计量机构接收颗粒的空气分配系统，所述空气分配系统包括用于在具有流量的空气流中输送颗粒的一排管，以及用于选择性地控制流量的管子上的阻尼机构在银行内; 空气流源，用于向管堤提供空气流; 位于每个管的粒子速度传感器，用于提供对应于测量的粒子速度的传感器输出信号; 以及可操作地连接到传感器和阻尼机构的控制机构，用于选择性地调节管组中的流量，该控制机构适于接收传感器输出信号，使对应于传感器输出信号的值归一化，以及显示归一化值。

2. 发明授权

US06296425B1 Method for controlling the flow rate of an air seeder 有权
标题翻译：控制播种机流量的方法
公开(公告)号：US06296425B1
公开(公告)日：2001-10-02
申请号：US09678673
申请日：2000-10-04
申请人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
发明人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
IPC分类号： B65G5300
CPC分类号： A01C7/081 , A01C7/105 , G01F1/7086 , Y02P60/16
摘要： An apparatus for dispensing particles includes a storage tank for containing particles to be dispensed a metering mechanism for transferring particles from the storage tank and an air distribution system for receiving particles from the metering mechanism The air distribution system includes a bank of tubes for transporting particles in a flow of air having a flow rate, and a damper mechanism at the bank of tubes for selective control of the flow rate within the bank of tubes. The apparatus for dispensing particles also includes an air flow source for providing a flow of air to the bank of tubes, a sensor located at each tube for providing a sensor output signal indicative of a value of a flow characteristic, and a controller operably connected to the sensors and to the damper mechanism. The controller automatically effects an adjustment of the flow rate in the bank of tubes by receiving the sensor output signals, normalizing the values corresponding to the sensor output signals, and automatically effecting an adjustment of the damper mechanism as a function of the normalized values and a target value.
摘要翻译：用于分配颗粒的装置包括用于容纳要分配用于从储罐传送颗粒的计量机构的颗粒的储存罐和用于从计量机构接收颗粒的空气分配系统。空气分配系统包括用于输送颗粒的管子组具有流量的空气流，以及用于选择性地控制管组内的流量的管堤处的阻尼机构。用于分配颗粒的设备还包括用于向管组提供空气流的空气流源，位于每个管处的传感器，用于提供表示流量特性的值的传感器输出信号，以及可操作地连接到传感器和阻尼器机构。控制器通过接收传感器输出信号，对与传感器输出信号相对应的值进行归一化，自动实现对管组中流量的调节，并根据归一化值自动实现阻尼机构的调整，目标价值。

3. 发明授权

US06192813B1 Apparatus for controlling the flow rate of an air seeder 有权
标题翻译：用于控制播种机流量的装置
公开(公告)号：US06192813B1
公开(公告)日：2001-02-27
申请号：US09455154
申请日：1999-12-06
申请人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
发明人： Russell J. Memory , Robert K. Benneweis , Neil D. Klassen , Robert J. Wilson , James N. Wilson
IPC分类号： A01C720
CPC分类号： A01C7/081 , A01C7/105 , G01F1/7086 , Y02P60/16
摘要： An apparatus for dispensing particles includes a storage tank for containing particles to be dispensed a metering mechanism for transferring particles from the storage tank and an air distribution system for receiving particles from the metering mechanism. The air distribution system includes a bank of tubes for transporting particles in a flow of air having a flow rate, and a damper mechanism at the bank of tubes for selective control of the flow rate within the bank of tubes. The apparatus for dispensing particles also includes an air flow source for providing a flow of air to the bank of tubes, a sensor located at each tube for providing a sensor output signal indicative of a value of a flow characteristic, and a controller operably connected to the sensors and to the damper mechanism. The controller automatically effects an adjustment of the flow rate in the bank of tubes by receiving the sensor output signals, normalizing the values corresponding to the sensor output signals, and automatically effecting an adjustment of the damper mechanism as a function of the normalized values and a target value.
摘要翻译：用于分配颗粒的装置包括用于容纳要分配用于从储罐传送颗粒的计量机构的颗粒的储罐和用于从计量机构接收颗粒的空气分配系统。空气分配系统包括用于在具有流量的空气流中输送颗粒的管子组，以及用于选择性地控制管组内的流量的管子组的阻尼机构。用于分配颗粒的设备还包括用于向管组提供空气流的空气流源，位于每个管处的传感器，用于提供表示流量特性的值的传感器输出信号，以及可操作地连接到传感器和阻尼器机构。控制器通过接收传感器输出信号，对与传感器输出信号相对应的值进行归一化，自动实现对管组中流量的调节，并根据归一化值自动实现阻尼机构的调整，目标价值。

4. 发明授权

US4825146A Unthreshed head grain loss monitor 失效
标题翻译：不开眼的粮食损失监测器
公开(公告)号：US4825146A
公开(公告)日：1989-04-25
申请号：US190240
申请日：1988-05-04
申请人： Wayne M. Kotyk , Thomas G. Kirk , Robert J. Wilson , James N. Wilson
发明人： Wayne M. Kotyk , Thomas G. Kirk , Robert J. Wilson , James N. Wilson
IPC分类号： A01D41/127 , G01N22/00 , G01R27/00
CPC分类号： A01D41/1273 , G01N22/00 , Y10S56/15
摘要： A device for indicating grain loss resulting from unthreshed heads in a combine harvester using a microwave transmitter-sensor. The device provides an output signal whose magnitude is a function of the mass of passing effluent which when compared to that of a typical threshed head provides a measure of unthreshed head grain loss.The device further provides that the output signal for unthreshed heads is distinct from that of loose grain providing means of distinguishing unthreshed head grain loss and loose grain loss.
摘要翻译：一种用于指示使用微波发射器 - 传感器的联合收割机中的无开头的谷物损失的装置。该装置提供输出信号，其大小是通过流出物的质量的函数，当与典型的开头头的质量相比时，输出信号提供了非开度的头部谷物损失的量度。该装置进一步规定，用于非开度头部的输出信号不同于松散颗粒提供装置，其区分未磨碎的头部谷物损失和松散的谷物损失。

5. 发明申请

US20120294808A1 Fluorescent Analogs of Neurotransmitters, Compositions Containing the Same and Methods of Using the Same 审中-公开
标题翻译：神经递质的荧光类似物，含有它们的组合物和使用它的方法
公开(公告)号：US20120294808A1
公开(公告)日：2012-11-22
申请号：US13508580
申请日：2010-11-09
申请人： James N. Wilson
发明人： James N. Wilson
IPC分类号： A61K49/00 , G01N21/64 , C07D221/14 , C07D513/04 , C07D215/227 , C07D213/30
CPC分类号： G01N33/533
摘要： A method of imaging using selective fluorescent emitters and compositions for imaging are described. The method can include contacting a specimen with a composition comprising at least one selective fluorescent emitter of Formulas I through IX and irradiating the specimen with an excitation wavelength. The fluorescence emitted by the selective fluorescent emitter can be detected to generate an image. Formulas I through IX are: wherein: R1=OR4 or NR3R4; R2=OR4, NR3R4, Cl, F or H; R3=H, CH3, C2H5, C3H7 or C4H9; R4=H, CH3, C2H5, C3H7 or C4H9; R5=H or CH2(CH2)nNR3R4; R6=H or CH2(CH2)nNR3R4; R7=OR4, NR3R4, Cl, F or H; R8=N-methylpyridinium or N-methyl-1,2,3,6-tetrahydropyridine; and n=1, 2 or 3.
摘要翻译：描述了使用选择性荧光发射器和用于成像的组合物成像的方法。该方法可以包括使样品与包含至少一种式I至IX的选择性荧光发射体的组合物接触并用激发波长照射样品。可以检测由选择性荧光发射器发射的荧光以产生图像。式I至IX的化合物是：其中：R1 = OR4或NR3R4; R2 = OR4，NR3R4，Cl，F或H; R3 = H，CH3，C2H5，C3H7或C4H9; R4 = H，CH3，C2H5，C3H7或C4H9; R5 = H或CH2（CH2）nNR3R4; R6 = H或CH2（CH2）nNR3R4; R7 = OR4，NR3R4，Cl，F或H; R8 = N-甲基吡啶鎓或N-甲基-1,2,3,6-四氢吡啶; n = 1,2或3。

6. 发明授权

US08268977B2 Strongly quenching oligomeric excimer/quencher pairs for detection schemes 有权
标题翻译：用于检测方案强烈猝灭低聚准分子/猝灭剂对
公开(公告)号：US08268977B2
公开(公告)日：2012-09-18
申请号：US12619559
申请日：2009-11-16
申请人： Eric Todd Kool , James N. Wilson , Nan Dai
发明人： Eric Todd Kool , James N. Wilson , Nan Dai
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C07H7/04 , C07H19/207 , C07H21/04
摘要： Compositions and systems are provided for the high efficiency quenching small water-soluble oligomers, or oligofluors, of from about 1-10 kd in size, where the oligofluors comprise multiple excimeric or exciplex forming fluorophores arranged on a scaffold, which are efficiently quenched by a quencher entity linked to the oligomer through a cleavable moiety. Fluorophores of interest include, without limitation, aromatic fluorophores such as pyrenes, e.g. benzopyrene, perylene, pyrene, etc. In some embodiments the oligofluor/quencher combination provides for a Stern-Vollmer constant (KSV) of greater than about 106 M−1, and may be greater than about 107 M−1, greater than about 108 M−1, or more. In some embodiments of the invention, the scaffold is a phosphodiester/glycoside backbone, e.g. an analog of a polynucleotide. The system of oligofluors and quenchers can be used in qualitative and quantitative screening and detection methods to detect any enzymatic, chemical or catalytic activity that can cleave the moiety between the quencher and scaffold.
摘要翻译：提供了大约1-10kd的高效猝灭小水溶性低聚物或寡聚物的组合物和体系，其中寡聚体包含多个形成配位在支架上的离子聚合物或激元形成荧光团，其被有效地淬灭猝灭剂实体通过可切割部分与低聚物连接。感兴趣的荧光团包括但不限于芳族荧光团如芘，苯芘，苝，芘等。在一些实施方案中，寡氟/猝灭剂组合提供大于约106M-1的斯特 - 沃尔默常数（KSV），并且可以大于约107M -1，大于约108 M-1或更多。在本发明的一些实施方案中，支架是磷酸二酯/糖苷骨架，例如多核苷酸的类似物。寡聚体和猝灭剂的系统可用于定性和定量筛选和检测方法，以检测可以切割猝灭剂和支架之间部分的任何酶，化学或催化活性。

7. 发明申请

US20100129820A1 STRONGLY QUENCHING OLIGOMERIC EXCIMER/QUENCHER PAIRS FOR DETECTION SCHEMES 有权
标题翻译：用于检测方案的强力检测低通滤镜/镊子对
公开(公告)号：US20100129820A1
公开(公告)日：2010-05-27
申请号：US12619559
申请日：2009-11-16
申请人： Eric Todd Kool , James N. Wilson , Nan Dai
发明人： Eric Todd Kool , James N. Wilson , Nan Dai
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C07H7/04 , C07H19/207 , C07H21/04
摘要： Compositions and systems are provided for the high efficiency quenching small water-soluble oligomers, or oligofluors, of from about 1-10 kd in size, where the oligofluors comprise multiple excimeric or exciplex forming fluorophores arranged on a scaffold, which are efficiently quenched by a quencher entity linked to the oligomer through a cleavable moiety. Fluorophores of interest include, without limitation, aromatic fluorophores such as pyrenes, e.g. benzopyrene, perylene, pyrene, etc. In some embodiments the oligofluor/quencher combination provides for a Stern-Vollmer constant (KSV) of greater than about 106 M−1, and may be greater than about 107 M−1, greater than about 108 M−1, or more. In some embodiments of the invention, the scaffold is a phosphodiester/glycoside backbone, e.g. an analog of a polynucleotide. The system of oligofluors and quenchers can be used in qualitative and quantitative screening and detection methods to detect any enzymatic, chemical or catalytic activity that can cleave the moiety between the quencher and scaffold.
摘要翻译：提供了大约1-10kd的高效猝灭小水溶性低聚物或寡聚物的组合物和体系，其中寡聚体包含多个形成配位在支架上的离子聚合物或激元形成荧光团，其被有效地淬灭猝灭剂实体通过可切割部分与低聚物连接。感兴趣的荧光团包括但不限于芳族荧光团如芘，苯芘，苝，芘等。在一些实施方案中，寡氟/猝灭剂组合提供大于约106M-1的斯特 - 沃尔默常数（KSV），并且可以大于约107M -1，大于约108 M-1或更多。在本发明的一些实施方案中，支架是磷酸二酯/糖苷骨架，例如多核苷酸的类似物。寡聚体和猝灭剂的系统可用于定性和定量筛选和检测方法，以检测可以切割猝灭剂和支架之间部分的任何酶，化学或催化活性。

8. 发明授权

US06818180B2 Devices for testing for the presence and/or concentration of an analyte in a body fluid 失效
标题翻译：用于测试体液中分析物的存在和/或浓度的装置
公开(公告)号：US06818180B2
公开(公告)日：2004-11-16
申请号：US09879898
申请日：2001-06-14
申请人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
发明人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
IPC分类号： G01N3348
CPC分类号： G01N33/54366 , G01N33/521 , Y10S435/805
摘要： Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a membrane or matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix. The devices also provide for microtitration of fluid samples in fixed volumetric openings containing indicator reagent. Another aspect of the device provides a determination of hematocrit level in whole blood in combination with indicator indication of analyte concentration which can be compensated for the hematocrit level. The devices provided are low cost.
摘要翻译：使用干化学染料指示剂系统用于体液分析的装置和方法，例如全血中的葡萄糖水平，通过掺入具有皮肤侧的多孔膜来提供，该多孔膜能够分离全血并在目视上读取指示剂而不去除红细胞部分的血液从膜。这些装置还使得能够通过使用膜或基质来使指示器可视化地读取，所述膜或基质将血液的横向流动中的全血分离通过矩阵从输入区域到基质的测试区域。该装置还提供含有指示剂试剂的固定体积开口中的液体样品的微量滴定。该装置的另一方面提供了全血中的血细胞比容水平的确定以及可补偿血细胞比容水平的分析物浓度的指示剂指示。所提供的设备成本低廉。

9. 发明授权

US5962215A Methods for testing the concentration of an analyte in a body fluid 失效
标题翻译：用于测试体液中分析物浓度的方法
公开(公告)号：US5962215A
公开(公告)日：1999-10-05
申请号：US628489
申请日：1996-04-05
申请人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
发明人： Joel S. Douglas , Karen R. Drexler , James N. Wilson
IPC分类号： G01N33/48 , C12Q1/00 , C12Q1/54 , G01N33/487 , G01N33/52 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/521 , Y10S435/805
摘要： Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a cellulose fiber glass composite matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix. Another aspect of the device provides a determination of hematocrit level in whole blood by measuring flow rate through a restricted passageway in the device.
摘要翻译：使用干化学染料指示剂系统用于体液分析的装置和方法，例如全血中的葡萄糖水平，通过掺入具有皮肤侧的多孔膜来提供，该多孔膜能够分离全血并在目视上读取指示剂而不去除红细胞部分的血液从膜。该装置还能够通过使用纤维素纤维玻璃复合物基质来使指示剂视觉阅读，所述纤维素玻璃复合物基质通过基质从输入区域到基质的测试区域提供血液横向流动中的全血分离。该装置的另一方面通过测量通过装置中的限制通道的流速来提供全血血细胞比容水平的确定。

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