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1. 发明授权

US5629288A Lipopeptide derivatives, a process for their preparation and their use 失效
标题翻译：脂肽衍生物，其制备方法及其用途
公开(公告)号：US5629288A
公开(公告)日：1997-05-13
申请号：US411931
申请日：1995-03-28
申请人： Rudolf Lattrell , Theodor Wollmann , Holger Wallmeier , Peter Hammann , Dieter Isert
发明人： Rudolf Lattrell , Theodor Wollmann , Holger Wallmeier , Peter Hammann , Dieter Isert
IPC分类号： A61K38/00 , A61K38/08 , A61K38/12 , A61P31/00 , A61P31/04 , C07K7/06 , C07K7/56 , C07K7/60 , C07K14/195 , C07K14/41
CPC分类号： C07K7/56 , A61K38/00
摘要： Lipopeptide derivatives of the formula I ##STR1## with R.sup.1 equal to OH or NH.sub.2 and R.sup.2 a C.sub.8 -C.sub.22 -acyl radical, pharmaceutical products which are effective for bacterial infections and contain such lipopeptide derivatives, process for preparing the lipopeptide derivatives and the pharmaceutical products, and the use of the lipopeptide derivatives for controlling bacterial infections are described.
摘要翻译：式I的脂肽衍生物，其中R1等于OH或NH2，R2为C8-C22-酰基，对细菌感染有效并含有这种脂肽衍生物的药物产品，制备脂肽衍生物的方法和药物描述了用于控制细菌感染的脂肽衍生物的用途。

2. 发明授权

US6127346A Phosphonomonoester nucleic acids process for their preparation and their use 有权
标题翻译：膦膦酸酯核酸的制备及其用途
公开(公告)号：US6127346A
公开(公告)日：2000-10-03
申请号：US196132
申请日：1998-11-20
申请人： Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
发明人： Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
IPC分类号： A61K31/66 , A01N43/04 , A61K31/7088 , A61P31/16 , A61P31/18 , A61P35/00 , A61P43/00 , C07F9/38 , C07F9/40 , C07H19/00 , C07H21/00 , C07H21/02 , C07K14/00 , C12Q1/68 , C12Q1/70
CPC分类号： C07H21/00 , C07F9/4006 , C07F9/4087 , C07K14/003
摘要： Novel oligonucleotide analogs of the formula [I] are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R.sup.5, R.sup.6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.
摘要翻译：描述了式[I]的新型寡核苷酸类似物，其中A，B，D，G，L，P，Q，Q'，R 5，R 6，X，Y，Z和n如说明书中所定义，具有有用的物理，生物和药理性质，以及它们的制备方法。其应用涉及用作基因表达抑制剂（反义寡核苷酸，核酶，有义寡核苷酸和三重复合形成寡核苷酸），作为用于检测核酸的探针和分子生物学中的辅助物质。

3. 发明申请

US20130004513A1 AGENTS FOR TREATING DISEASE 有权
标题翻译：治疗疾病的药剂
公开(公告)号：US20130004513A1
公开(公告)日：2013-01-03
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
IPC分类号： A61K39/395 , C07K16/28 , C40B30/04 , C07K19/00 , C07K9/00 , C07K14/73 , C12N15/13 , C12N15/63 , C12P21/00 , C12N5/0783 , A61P37/06 , C12N1/19 , C12N5/10 , C12N5/12 , H01F1/42 , G06F19/10 , A61M37/00 , G01N23/207 , G01R33/46 , G01N33/53
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
摘要翻译：提供了筛选以鉴定能够结合CD4并能够激活CD4 + CD25 +调节性T细胞的分子的方法。进一步提供能够激活CD4 + CD25 +调节性T细胞的抗体和抗体片段以及涉及抗体及其片段的方法和用途。

4. 发明授权

US09995733B2 Agents for treating disease 有权
公开(公告)号：US09995733B2
公开(公告)日：2018-06-12
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
IPC分类号： G01N33/48 , G01N33/50 , C07K16/28 , G06G7/58
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.

5. 发明授权

US5874553A Phosphonomonoester nucleic acids, process for their preparation, and their use 失效
标题翻译：膦膦酸核酸，其制备方法及其用途
公开(公告)号：US5874553A
公开(公告)日：1999-02-23
申请号：US613417
申请日：1996-03-11
申请人： Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
发明人： Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
IPC分类号： A61K31/66 , A01N43/04 , A61K31/7088 , A61P31/16 , A61P31/18 , A61P35/00 , A61P43/00 , C07F9/38 , C07F9/40 , C07H19/00 , C07H21/00 , C07H21/02 , C07K14/00 , C12Q1/68 , C12Q1/70 , A01N61/00
CPC分类号： C07H21/00 , C07F9/4006 , C07F9/4087 , C07K14/003
摘要： Novel oligonucleotide analogs of the formula (I) are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R.sup.5, R.sup.6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.
摘要翻译：描述式（I）的新型寡核苷酸类似物，其中A，B，D，G，L，P，Q，Q'，R 5，R 6，X，Y，Z和n分别为在描述中定义，其具有有用的物理，生物和药理学性质，以及它们的制备方法。其应用涉及用作基因表达抑制剂（反义寡核苷酸，核酶，有义寡核苷酸和三重复合形成寡核苷酸），作为用于检测核酸的探针和分子生物学中的辅助物质。

6. 发明授权

US5426036A Processes for the preparation of foreign proteins in streptomycetes 失效
标题翻译：在链霉菌中制备外源蛋白的方法
公开(公告)号：US5426036A
公开(公告)日：1995-06-20
申请号：US30731
申请日：1993-03-12
申请人： Klaus-Peter Koller , Gunther Riess , Eugen Uhlmann , Holger Wallmeier
发明人： Klaus-Peter Koller , Gunther Riess , Eugen Uhlmann , Holger Wallmeier
IPC分类号： C07K14/36 , C07K14/62 , C12N15/76 , C12N15/62
CPC分类号： C07K14/62 , C07K14/36 , C12N15/76 , C07K2319/02 , C07K2319/75
摘要： The tendamistat gene can be used for the construction of fused genes with which fusion proteins are expressed and excreted in Streptomycetes host cells. The tendamistat portion can be modified, in particular it can be C-terminal shortened. When a gene for a shortened proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construction is introduced into an expression vector, and the latter is used to transform a Streptomycetes host cell, there is expression and secretion of the corresponding fusion protein. The fusion protein can easily be cleaved to give insulin precursors because of correctly established disulfide bonds. Genetic structures which code for the signal sequence and about the first ten amino acids of tendamistat as well as a desired protein are expressed in streptomyces host cells with a high yield, and the fusion proteins are secreted into the medium.
摘要翻译：该趋化因子基因可用于构建融合蛋白的融合蛋白，其在链霉菌宿主细胞中表达和排泄。可以修改卷曲部分，特别是可以缩短C端。当胰岛素B链仅通过Lys或Lys-Lys与A链连接的缩短的胰岛素原的基因与趋化因子基因偶联时，将该基因构建引入表达载体中，并将后者用于转化链霉菌宿主细胞，有相应融合蛋白的表达和分泌。由于正确建立的二硫键，融合蛋白可以容易地被切割以产生胰岛素前体。编码信号序列和约10个氨基酸的趋化因子以及所需蛋白质的遗传结构以高产量在链霉菌宿主细胞中表达，融合蛋白分泌到培养基中。

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