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1. 发明授权

US06383496B1 Recombinant vaccines comprising immunogenic attenuated bacteria having RPOS positive phenotype 失效
标题翻译：包含具有RPOS阳性表型的免疫原性减毒细菌的重组疫苗
公开(公告)号：US06383496B1
公开(公告)日：2002-05-07
申请号：US09314062
申请日：1999-05-18
申请人： Roy Curtiss, III , Cheryl A. Nickerson
发明人： Roy Curtiss, III , Cheryl A. Nickerson
IPC分类号： A61K3902
CPC分类号： A61K39/12 , A61K35/74 , A61K39/0006 , A61K39/0275 , A61K39/292 , A61K39/35 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N1/22 , C12N2730/10134 , Y02A50/482 , Y02A50/484 , Y10S435/879 , Y10S435/897 , A61K2300/00
摘要： Attenuated immunogenic bacteria having an RpoS+ phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS+ phenotype and methods therefor are disclosed. The Salmonella have in addition to an RpoS+ phenotype, an inactivating mutation in one or more genes which render the microbe attenuated, and a recombinant gene capable of expressing a desired protein. The Salmonella are attenuated and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for genes and gene products. Also disclosed are methods for preparing the vaccine delivery vehicles.
摘要翻译：公开了具有RpoS +表型的具有RpoS +表型的减毒免疫原性细菌，特别是具有RpoS +表型的肠炎沙门氏菌血清型Typhi及其方法。除了RpoS +表型之外，沙门氏菌还有一种或多种使微生物减毒的基因中的失活突变，以及能够表达所需蛋白质的重组基因。沙门氏菌减毒，免疫原性高，可用于疫苗和作为基因和基因产物的递送载体。还公开了制备疫苗递送载体的方法。

2. 发明授权

US07083794B2 Recombinant vaccines comprising immunogenic attenuated bacteria having RpoS positive phenotype 有权
标题翻译：包含具有RpoS阳性表型的免疫原性减毒细菌的重组疫苗
公开(公告)号：US07083794B2
公开(公告)日：2006-08-01
申请号：US10138239
申请日：2002-05-03
申请人： Roy Curtiss, III , Cheryl A. Nickerson
发明人： Roy Curtiss, III , Cheryl A. Nickerson
IPC分类号： A61K39/02 , A61K39/112 , C12N15/74 , C12N1/21
CPC分类号： A61K39/12 , A61K35/74 , A61K39/0006 , A61K39/0275 , A61K39/292 , A61K39/35 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N1/22 , C12N2730/10134 , Y02A50/482 , Y02A50/484 , Y10S435/879 , Y10S435/897 , A61K2300/00
摘要： Attenuated immunogenic bacteria having an RpoS+ phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS+ phenotype and methods therefor are disclosed. The Salmonella have in addition to an RpoS+ phenotype, an inactivating mutation in one or more genes which render the microbe attenuated, and a recombinant gene capable of expressing a desired protein. The Salmonella are attenuated and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for genes and gene products. Also disclosed are methods for preparing the vaccine delivery vehicles.
摘要翻译：公开了具有RpoS + / / SUP表型的减毒免疫原细菌，特别是具有RpoS +表型的肠炎沙门氏菌血清型Typhi及其方法。沙门氏菌除了具有RpoS 表型外，一种或多种使微生物减毒的基因中的失活突变，以及能够表达所需蛋白质的重组基因。沙门氏菌减毒，免疫原性高，可用于疫苗和作为基因和基因产物的递送载体。还公开了制备疫苗递送载体的方法。

3. 发明授权

US6024961A Recombinant avirulent immunogenic S typhi having rpos positive phenotype 失效
标题翻译：具有rpos阳性表型的重组无毒免疫原性S typhi
公开(公告)号：US6024961A
公开(公告)日：2000-02-15
申请号：US970789
申请日：1997-11-14
申请人： Roy Curtiss, III , Cheryl A. Nickerson
发明人： Roy Curtiss, III , Cheryl A. Nickerson
IPC分类号： C12N15/09 , A61K35/74 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/112 , A61K39/12 , A61K39/29 , A61K39/35 , A61K48/00 , A61P31/00 , A61P31/04 , C12N1/21 , C12N1/22 , A61K39/02 , A61K39/116 , A61K39/295
CPC分类号： A61K39/12 , A61K35/74 , A61K39/0006 , A61K39/0275 , A61K39/292 , A61K39/35 , A61K48/00 , C12N1/22 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N2730/10134 , Y10S435/879 , Y10S435/897
摘要： Avirulent immunogenic Salmonella enterica serotype Typhi and methods therefor are disclosed. The Salmonella have an RpoS.sup.+ phenotype, an inactivating mutation in one or more genes which renders the microbe avirulent, and a recombinant gene capable of expressing a desired protein. The Salmonella are avirulent and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for the desired antigen. Also disclosed are methods for preparing the Salmonella and vaccine delivery vehicles therefor.
摘要翻译：公开了无毒性免疫原性肠炎沙门氏菌血清型伤寒及其方法。沙门氏菌具有RpoS +表型，一种或多种使无微生物微生物的基因中的失活突变，以及能够表达所需蛋白质的重组基因。沙门氏菌是无毒的并且具有高免疫原性，使得它们可以用于疫苗和用作所需抗原的递送载体。还公开了用于制备沙门氏菌和疫苗递送载体的方法。

4. 发明授权

US09481888B2 Recombinant bacterium and methods of antigen and nucleic acid delivery 有权
标题翻译：重组细菌和抗原和核酸递送方法
公开(公告)号：US09481888B2
公开(公告)日：2016-11-01
申请号：US13302575
申请日：2011-11-22
申请人： Roy Curtiss, III , Wei Kong
发明人： Roy Curtiss, III , Wei Kong
IPC分类号： C12N15/74 , C12N1/36 , A61K39/02 , C12N9/10 , C07K14/255 , A61K39/112 , A61K39/09
CPC分类号： C12N15/74 , A61K39/0275 , A61K39/092 , C12N1/36 , C12N9/1048
摘要： The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce an immune response.
摘要翻译：本发明提供重组细菌和使用重组细菌诱导免疫应答的方法。

5. 发明申请

US20110256181A1 RECOMBINANT BACTERIUM CAPABLE OF ELICITING A PROTECTIVE IMMUNE RESPONSE AGAINST C. PERFRINGENS 有权
标题翻译：针对C. PERFRINGENS提供保护性免疫应答的重组细菌
公开(公告)号：US20110256181A1
公开(公告)日：2011-10-20
申请号：US12681711
申请日：2008-10-06
申请人： Roy Curtiss, III , Bereket Zekarias , Kenneth Roland
发明人： Roy Curtiss, III , Bereket Zekarias , Kenneth Roland
IPC分类号： A61K39/112 , C12N1/21
CPC分类号： A61K39/0275 , A61K39/025 , A61K2039/522 , A61K2039/523 , C12N15/74 , Y02A50/47 , Y02A50/482 , Y02A50/484
摘要： The present invention encompasses recombinant bacteria and immunogenic compositions comprising the bacteria. The immunogenic composition may be used to induce an immune response against C. perfringens.
摘要翻译：本发明包括重组细菌和包含细菌的免疫原性组合物。免疫原性组合物可用于诱导针对产气荚膜梭菌的免疫应答。

6. 发明申请

US20110159594A1 NUCLEIC ACIDS, BACTERIA, AND METHODS FOR DEGRADING THE PEPTIDOGLYCAN LAYER OF A CELL WALL 审中-公开
标题翻译：用于降解细胞壁的细胞壁的核酸，细菌和方法
公开(公告)号：US20110159594A1
公开(公告)日：2011-06-30
申请号：US12999840
申请日：2009-06-17
申请人： Roy Curtiss, III , Xinyao Liu
发明人： Roy Curtiss, III , Xinyao Liu
IPC分类号： C12N15/63 , C12N15/74 , C12N1/21
CPC分类号： C12N1/06 , C12N9/2462 , C12N2830/002 , C12N2830/55 , C12Y302/01017
摘要： The invention encompasses compositions and methods for degrading the peptidoglycan layer of a cell wall. In particular, the invention encompasses compositions and methods for degrading the peptidoglycan layer of the cell wall of a gram-negative bacterium.
摘要翻译：本发明包括用于降解细胞壁的肽聚糖层的组合物和方法。特别地，本发明包括用于降解革兰氏阴性细菌细胞壁的肽聚糖层的组合物和方法。

7. 发明授权

US07871604B1 Recombinant bacterial vaccine system with environmentally limited viability 失效
标题翻译：具有环境有限生命力的重组细菌疫苗系统
公开(公告)号：US07871604B1
公开(公告)日：2011-01-18
申请号：US09120970
申请日：1998-07-22
申请人： Roy Curtiss, III , Steven A. Tinge
发明人： Roy Curtiss, III , Steven A. Tinge
IPC分类号： C12N1/21 , A01N63/00
CPC分类号： C12N15/64 , C12N15/70 , C12N15/74
摘要： Disclosed is an Environmentally Limited Viability System (ELVS) for microorganisms based on temperature differences between permissive and non-permissive environments. Viability of the microorganisms are limited to the permissive environment by specifically expressing one or more essential genes only in the permissive environment, or expressing one or more lethal genes only in the non-permissive environment. Environmentally Limited Viability Systems are also disclosed involving coordinate expression of a combination of required genes and lethal genes. Microorganisms containing an Environmentally Limited Viability System are useful for release into a permissive environment. Temperature regulated Environmentally Limited Viability Systems are particularly suited for use with recombinant avirulent Salmonella vaccines by limiting their growth to the warmer environment inside the host. Such vaccines can be administered to protect humans or warm-blooded animals against bacterial, viral, mycotic and parasitic pathogens, especially those that colonize on or invade through mucosal surfaces. This antigen delivery system can also be used for expression of gamete-specific antigens to induce immune responses to block fertilization, or to induce immune responses to tumor antigens. In the event that an individual sheds live vaccine into the environment, the presence of the ELVS prevents survival of the vaccine. When environmentally regulated lethal genes are present on an extrachromosomal element and are regulated by chromosomal genes, transfer of the extrachromosomal element to other microorganisms will be limited by unregulated expression of the lethal genes in the recipient microorganism.
摘要翻译：公开了基于许可和非允许环境之间的温度差异的微生物的环境有限的生存力系统（ELVS）。通过仅在许可环境中特异性表达一个或多个必需基因，或仅在非允许环境中表达一个或多个致死基因，微生物的活力受到许可环境的限制。还公开了环境有限的可行性系统，涉及协调所需基因和致死基因组合的表达。含有环境有限的生命力系统的微生物对于释放到允许的环境中是有用的。温度调节环境有限的生命力系统特别适用于重组无毒性沙门氏菌疫苗，通过将其生长限制在主机内较暖的环境中。可以施用这样的疫苗以保护人类或温血动物免受细菌，病毒，真菌和寄生虫病原体，特别是通过粘膜表面侵袭或入侵的病原体。该抗原递送系统还可用于表达配子特异性抗原以诱导阻断受精的免疫应答，或诱导对肿瘤抗原的免疫应答。如果一个人将活疫苗流入环境，则ELVS的存在可防止疫苗的存活。当环境调节的致死基因存在于染色体外元件上并且被染色体基因调节时，染色体外元件转移到其他微生物将受到受体微生物中致死基因的不受调节的表达的限制。

8. 发明授权

US5679880A Oral immunization by transgenic plants 失效
标题翻译：转基因植物的口服免疫
公开(公告)号：US5679880A
公开(公告)日：1997-10-21
申请号：US457928
申请日：1995-06-01
申请人： Roy Curtiss, III , Guy A. Cardineau
发明人： Roy Curtiss, III , Guy A. Cardineau
IPC分类号： A01H5/00 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/09 , A61K39/12 , C07K14/005 , C07K14/195 , C07K14/245 , C07K14/315 , C07K14/41 , C07K19/00 , C12N5/10 , C12N9/10 , C12N9/24 , C12N15/09 , C12N15/31 , C12N15/82 , C12P21/02 , C12P21/08 , G01N33/569
CPC分类号： C12N9/1051 , C07K14/245 , C07K14/315 , C12N15/8258 , C12N9/16 , C12N9/2454 , C12Y301/03001 , C12Y302/01011 , A61K39/00 , C07K2319/00
摘要： The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.
摘要翻译：本发明涉及表达由病原微生物的基因指定的定植和/或毒力抗原的转基因植物。还涉及这样的转基因植物用于人和其他动物的口服免疫以引发分泌免疫应答，其通过人或其他动物的粘膜表面抑制这种致病微生物的定植或侵袭。

9. 发明授权

US4888170A Vaccines obtained from antigenic gene products of recombinant genes 失效
标题翻译：从重组基因的抗原基因产物获得的疫苗
公开(公告)号：US4888170A
公开(公告)日：1989-12-19
申请号：US773894
申请日：1985-09-09
申请人： Roy Curtiss, III
发明人： Roy Curtiss, III
IPC分类号： C07K14/195 , C07K14/315 , C12N1/21 , C12N9/10 , C12P21/00
CPC分类号： A61K39/0275 , A61K39/092 , C07K14/195 , C07K14/315 , C12N9/1051 , C12P21/00 , A61K2039/523 , A61K2039/542
摘要： This invention relates to a vaccine for the immunization of a vertebrate, comprising:an avirulent derivative of a pathogenic microbe that expresses a recombinant gene derived from a pathogen of said vertebrate it being provided that said avirulent microbe does not normally exchange genetic material with said pathogen, to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.
摘要翻译：本发明涉及用于免疫脊椎动物的疫苗，其包含：表达源自所述脊椎动物的病原体的重组基因的致病微生物的无毒性衍生物，其中所述无毒力微生物通常不与所述病原体交换遗传物质以产生能够在所述脊椎动物中针对所述病原体诱导免疫应答的抗原。

10. 发明授权

US09050285B2 Recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae 有权
标题翻译：能够引起针对肺炎链球菌的免疫应答的重组细菌
公开(公告)号：US09050285B2
公开(公告)日：2015-06-09
申请号：US13088141
申请日：2011-04-15
申请人： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
发明人： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
IPC分类号： A61K39/275 , A61K39/09 , A61K39/00
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/523 , Y02A50/484
摘要： The invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.
摘要翻译：本发明包括能够引起针对肺炎链球菌的免疫应答的重组细菌，包含该细菌的疫苗以及使用该细菌的方法。

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