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1. 发明申请

US20160158406A1 SELF-ASSEMBLING BIOMIMETIC HYDROGELS HAVING BIOADHESIVE PROPERTIES 审中-公开
标题翻译：具有生物性能的自组装生物水凝胶
公开(公告)号：US20160158406A1
公开(公告)日：2016-06-09
申请号：US15041170
申请日：2016-02-11
申请人： Rowan University
发明人： Andrea Jennifer Vernengo , Jennifer Kadlowec , Pamela Kubinski , Thomas N. Tulenko , Cristina Iftode , Bryan Johnson , Craig Wiltsey
IPC分类号： A61L24/04 , A61F2/00 , A61L24/00
CPC分类号： A61L24/043 , A61F2/0063 , A61F2002/0068 , A61F2310/0097 , A61L24/0015 , A61L24/0031 , A61L27/26 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/412 , A61L2300/62 , A61L2300/626 , A61L2400/06 , A61L2430/38 , C08G2210/00
摘要： The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.
摘要翻译：本公开涉及在低于哺乳动物体温的温度下为液体并且在哺乳动物体内或体外固化的组合物。该组合物包括散布于细胞外基质的聚合物组分和封闭形式的胺化合物（优选细胞外基质的胺化组分）的热脱溶化聚合物，其被包封在哺乳动物体内。聚合物组分能够与胺化组分中的胺部分，哺乳动物体内的一个或多个组织或两者形成共价键。在将这些组分的液体悬浮液注射到哺乳动物的体内时，热脱溶化的聚合物冷凝，截留聚合物组分。聚合物组分与体内的组织共价结合，并且胺化组分将聚合物组分的剩余反应性部分封端，在注射部位形成基质。本公开还涉及这种组合物在哺乳动物体内或体内形成基质的用途。组合物具有各种用途，例如生物粘合剂，作为破裂组织的密封剂，药物或成像剂贮库，或作为机械垫。

2. 发明申请

US20170000923A1 Self-Assembling Biomimetic Hydrogels Having Bioadhesive Properties 审中-公开
标题翻译：具有生物粘附性质的自组装仿生水凝胶
公开(公告)号：US20170000923A1
公开(公告)日：2017-01-05
申请号：US15269404
申请日：2016-09-19
申请人： Rowan University
发明人： Andrea J. Vernengo , Jennifer Kadlowec , Pamela Kubinski , Thomas N. Tulenko , Cristina Iftode , Bryan Johnson , Craig Wiltsey
IPC分类号： A61L24/04 , A61F2/00 , A61L24/00
CPC分类号： A61L24/043 , A61F2/0063 , A61F2002/0068 , A61F2310/0097 , A61L24/0015 , A61L24/0031 , A61L27/26 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/412 , A61L2300/62 , A61L2300/626 , A61L2400/06 , A61L2430/38 , C08G2210/00
摘要： The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection off liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.
摘要翻译：本公开涉及在低于哺乳动物体温的温度下为液体并且在哺乳动物体内或体外固化的组合物。该组合物包括散布于细胞外基质的聚合物组分和封闭形式的胺化合物（优选细胞外基质的胺化组分）的热脱溶化聚合物，其被包封在哺乳动物体内。聚合物组分能够与胺化组分中的胺部分，哺乳动物体内的一个或多个组织或两者形成共价键。当将这些组分的液体悬浮液注射到哺乳动物的体内时，热脱溶化聚合物冷凝，捕获聚合物组分。聚合物组分与身体中的组织共价结合，并且胺化组分将聚合物组分的剩余反应性部分封端，在注射部位形成基质。本公开还涉及这种组合物在哺乳动物体内或体内形成基质的用途。组合物具有各种用途，例如生物粘合剂，作为破裂组织的密封剂，药物或成像剂贮库，或作为机械垫。

3. 发明授权

US09295761B2 Self-assembling biomimetic hydrogels having bioadhesive properties 有权
公开(公告)号：US09295761B2
公开(公告)日：2016-03-29
申请号：US13652408
申请日：2012-10-15
申请人： Rowan University
发明人： Andrea Jennifer Vernengo , Jennifer Kadlowec , Pamela Kubinski , Thomas N Tulenko , Cristina Iftode , Bryan Johnson , Craig Wiltsey
IPC分类号： A61K9/00 , A61L27/52 , A61L27/26 , A61L27/36 , A61L27/38 , A61L27/54
CPC分类号： A61L24/043 , A61F2/0063 , A61F2002/0068 , A61F2310/0097 , A61L24/0015 , A61L24/0031 , A61L27/26 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/412 , A61L2300/62 , A61L2300/626 , A61L2400/06 , A61L2430/38 , C08G2210/00
摘要： The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.

4. 发明授权

US11179493B2 Methods and compositions for inducing multi-targeted healing of intervertebral disc defects 有权
公开(公告)号：US11179493B2
公开(公告)日：2021-11-23
申请号：US16090086
申请日：2017-04-06
申请人： ROWAN UNIVERSITY
发明人： Andrea Jennifer Vernengo , Thomas Richard Christiani , Cristina Iftode , Jennifer Kadlowec
IPC分类号： A61L27/20 , A61L27/16 , A61L27/52 , A61L27/58 , A61L27/54 , A61L27/50
摘要： The present disclosure relates to injectable compositions capable of forming a scaffold in situ at an intervertebral disc site, the composition comprising: (a) a biocompatible polymer; and (b) a biocompatible solvent system in sufficient amount to solubilize the biocompatible polymer in sufficient degree to allow injectable delivery to a disc site.

5. 发明授权

US09446167B2 Self-assembling biomimetic hydrogels having bioadhesive properties 有权
标题翻译：具有生物粘合性能的自组装仿生水凝胶
公开(公告)号：US09446167B2
公开(公告)日：2016-09-20
申请号：US15041170
申请日：2016-02-11
申请人： Rowan University
发明人： Andrea Jennifer Vernengo , Jennifer Kadlowec , Pamela Kubinski , Thomas N. Tulenko , Cristina Iftode , Bryan Johnson , Craig Wiltsey
IPC分类号： A61K9/00 , A61L24/04 , A61L24/00 , A61F2/00
CPC分类号： A61L24/043 , A61F2/0063 , A61F2002/0068 , A61F2310/0097 , A61L24/0015 , A61L24/0031 , A61L27/26 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/412 , A61L2300/62 , A61L2300/626 , A61L2400/06 , A61L2430/38 , C08G2210/00
摘要： The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.
摘要翻译：本公开涉及在低于哺乳动物体温的温度下为液体并且在哺乳动物体内或体外固化的组合物。该组合物包括散布于细胞外基质的聚合物组分和封闭形式的胺化合物（优选细胞外基质的胺化组分）的热脱溶化聚合物，其被包封在哺乳动物体内。聚合物组分能够与胺化组分中的胺部分，哺乳动物体内的一个或多个组织或两者形成共价键。在将这些组分的液体悬浮液注射到哺乳动物的体内时，热脱溶化的聚合物冷凝，截留聚合物组分。聚合物组分与体内的组织共价结合，并且胺化组分将聚合物组分的剩余反应性部分封端，在注射部位形成基质。本公开还涉及这种组合物在哺乳动物体内或体内形成基质的用途。组合物具有各种用途，例如生物粘合剂，作为破裂组织的密封剂，药物或成像剂贮库，或作为机械垫。

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