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1. 发明申请

US20070059730A1 Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor 失效
标题翻译：小分子25869,25934,26335,5049,21117,38692,46508,16816,16839,49937,49931和49933分子及其用途
公开(公告)号：US20070059730A1
公开(公告)日：2007-03-15
申请号：US11445606
申请日：2006-06-02
申请人： Rory Curtis , Thomas Logan , Maria Glucksmann , Rachel Meyers , Mark Williamson , Laura Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory Curtis , Thomas Logan , Maria Glucksmann , Rachel Meyers , Mark Williamson , Laura Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00 , C07K14/705
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K14/395 , C07K14/43545 , C07K14/43581 , C07K14/43595 , C07K14/463 , C07K14/465 , C07K14/47 , C07K2319/00 , C12N9/00 , C12N9/0071 , C12N9/0083 , C12N9/1205 , C12N9/18 , C12N9/20 , C12N9/88 , C12N2310/3513 , C12Y207/01001 , C12Y301/04003
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明申请

US20060116508A1 Novel 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 molecules and uses therefor 失效
标题翻译：新的27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A ，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B，NARC 9，NARC2A，NARC 16B，NARC 1C ，NARC 1A，NARC 25，86604和32222分子及其用途
公开(公告)号：US20060116508A1
公开(公告)日：2006-06-01
申请号：US11313836
申请日：2005-12-21
申请人： Maria Glucksmann , Mark Williamson , Fong-Ying Tsai , Laura Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel Meyers , Lillian Chiang , John Hunter
发明人： Maria Glucksmann , Mark Williamson , Fong-Ying Tsai , Laura Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel Meyers , Lillian Chiang , John Hunter
IPC分类号： C07H21/04 , C12P21/06 , C12N9/16
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

3. 发明申请

US20070048784A1 Novel human hydrolase family members and uses thereof 审中-公开
标题翻译：新型人类水解酶家族成员及其用途
公开(公告)号：US20070048784A1
公开(公告)日：2007-03-01
申请号：US11591659
申请日：2006-11-01
申请人： Rachel Meyers , Maria Glucksmann , Rory Curtis , Laura Rudolph-Owen
发明人： Rachel Meyers , Maria Glucksmann , Rory Curtis , Laura Rudolph-Owen
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/16 , C07K16/40
CPC分类号： C12Q1/6883 , C12N9/82 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人水解酶家族成员的分离的核酸分子，命名为26443和46873核酸分子。本发明还提供了反义核酸分子，含有26443和46873核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及引入或破坏了26443和46873基因的非人类转基因动物。本发明还进一步提供分离的26443和46873蛋白，融合蛋白，抗原肽和抗26443或46873抗体。还提供了利用本发明组合物的诊断方法。

4. 发明申请

US20080051322A1 14400, 2838, 14618, 15334, 14274, 32164, 39404, 38911, 26904, 31237, 18057, 16405, 32705, 23224, 27423, 32700, 32712 and 12216, novel seven-transmembrane proteins/G-protein coupled receptors 审中-公开
标题翻译： 14400,2838,14618,15334,14274,32164,39404,38911,26904,313237,18057,16405,32705,23224,27423,32700,32712和12216，新型七跨膜蛋白/ G蛋白偶联受体
公开(公告)号：US20080051322A1
公开(公告)日：2008-02-28
申请号：US11810360
申请日：2007-06-05
申请人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
发明人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
IPC分类号： A61K38/16 , A61K38/00 , A61P43/00 , C07H21/04 , C07K16/00 , C12N5/00 , C12P21/04 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/566 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K14/723 , C07K2319/00 , C12N9/16 , G01N2333/726
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译：本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。本发明还涉及编码受体的多核苷酸。本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生受体多肽和多核苷酸的方法。

5. 发明申请

US20060040357A1 Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 失效
公开(公告)号：US20060040357A1
公开(公告)日：2006-02-23
申请号：US11245400
申请日：2005-10-06
申请人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
发明人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
IPC分类号： C07H21/04 , C12P21/06 , C12N9/10 , C12N9/12
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

6. 发明申请

US20070099230A1 Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecles, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 审中-公开
标题翻译：编码黑素瘤相关抗原分子，氨基转移酶分子，ATP酶分子，酰基转移酶分子，吡哆醛 - 磷酸依赖性酶分子的新型核酸序列及其用途
公开(公告)号：US20070099230A1
公开(公告)日：2007-05-03
申请号：US11636665
申请日：2006-12-08
申请人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
发明人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新多肽的分离的核酸分子。本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。还提供了利用本发明组合物的诊断方法。

7. 发明申请

US20060014244A1 Novel nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and ATPase-like molecules and uses therefor 审中-公开
公开(公告)号：US20060014244A1
公开(公告)日：2006-01-19
申请号：US11040595
申请日：2005-01-21
申请人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
发明人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
IPC分类号： C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1229 , C07K14/47 , C12N9/1288 , C12N9/14 , G01N33/574 , G01N33/6896
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

8. 发明申请

US20050019838A1 Novel human membrane-associated protein and cell surface protein family members 审中-公开
标题翻译：新型人膜相关蛋白和细胞表面蛋白家族成员
公开(公告)号：US20050019838A1
公开(公告)日：2005-01-27
申请号：US10860779
申请日：2004-06-03
申请人： Rachel Meyers , Maria Glucksmann , Rory Curtis , Rosana Kapeller-Libermann , Rajasekhar Bandaru , Kevin Leiby
发明人： Rachel Meyers , Maria Glucksmann , Rory Curtis , Rosana Kapeller-Libermann , Rajasekhar Bandaru , Kevin Leiby
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , G01N33/53 , C07H21/04 , G01N33/567
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K14/70596 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 16051a, 16051b, 58199, 57805, 56739, 39362, and 23228 nucleic acid molecules, which encode novel human membrane-associated protein family members, and human cell surface protein family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 gene has been introduced or disrupted. The invention still further provides isolated 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 proteins, fusion proteins, antigenic peptides and anti-16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了编码新的人膜相关蛋白家族成员和人类细胞表面蛋白家族成员的分离的核酸分子，命名为16051a，16051b，58199,57805,56739,39362和23228核酸分子。本发明还提供反义核酸分子，含有16051a，16051b，58199,57805,56739,39362或23228核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中16051a ，16051b，58199,57805,56739,39362或23228基因被引入或破坏。本发明还进一步提供分离的16051a，16051b，58199,57805,56739,39362或23228蛋白，融合蛋白，抗原肽和抗-16051a，16051b，58199,57805,56739,39362或23228抗体。还提供了利用本发明组合物的诊断方法。

9. 发明申请

US20050214893A1 Novel human genes and methods of use thereof 审中-公开
标题翻译：新型人类基因及其使用方法
公开(公告)号：US20050214893A1
公开(公告)日：2005-09-29
申请号：US10968812
申请日：2004-10-19
申请人： Rachel Meyers , Rory Curtis , Maria Glucksmann , Rajasekhar Bandaru , Rosana Kapeller-Libermann
发明人： Rachel Meyers , Rory Curtis , Maria Glucksmann , Rajasekhar Bandaru , Rosana Kapeller-Libermann
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N9/02 , C12N9/10 , C12N9/48 , C12N9/90 , C12Q1/26 , G01N33/574
CPC分类号： C12N9/0004 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C12N9/1048 , C12N9/48 , C12N9/90 , G01N33/57411 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875,46842,33201, 83378,84233,64708, 85041,84234,21617, 55562,23566,33489, and 57779 nucleic acid molecules, which encode novel human genes. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人基因的分离的核酸分子，命名为47476,67210,49875,46842,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489和57779核酸分子。本发明还提供反义核酸分子，包含47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,161617,55562,23566,33489或57779核酸分子的重组表达载体，宿主细胞已经引入了表达载体的非人类转基因动物，以及引入了47476,67210,49875,4642,43708,85041,84234,16617,55562,23566,33489或57779基因的非人类转基因动物，或中断了本发明还进一步提供分离的47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489或57779号蛋白，融合蛋白，抗原肽和抗-47476,67210， 49875,4462,33201,83378,84233,66708,85041,84234,21617,55562,253566,33489或57779抗体。还提供了利用本发明组合物的诊断方法。

10. 发明申请

US20060008819A1 Novel 38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt molecules and uses therefor 审中-公开
标题翻译：小分子38594,57312,53659,57250,6360,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和57255分子及其用途
公开(公告)号：US20060008819A1
公开(公告)日：2006-01-12
申请号：US11043889
申请日：2005-01-25
申请人： Rory Curtis , Maria Glucksmann , Rachel Meyers
发明人： Rory Curtis , Maria Glucksmann , Rachel Meyers
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/16 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K2319/00 , C12N9/14 , C12N2310/3181 , C12N2310/351 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： The invention provides isolated nucleic acids molecules, designated 38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt nucleic acid molecules, which encode transporter molecules, including sugar transporters, organic anion transporters, amino acid transporters, and phospholipid transporters. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt gene has been introduced or disrupted. The invention still further provides isolated 38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt polypeptides, fusion polypeptides, antigenic peptides and anti-38594, 57312, 53659, 57250, 63760, 49938, 32146, 57259, 67118, 67067, 62092, FBH58295FL, 57255, and 57255alt antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为38594,57312,53659,57250,66360,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和57255alt核酸分子，其编码转运蛋白分子，包括糖转运蛋白，有机阴离子转运蛋白，氨基酸转运蛋白和磷脂转运蛋白。本发明还提供反义核酸分子，含有38594,57312,53659,57250,6360,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和5725589核酸分子的重组表达载体，宿主细胞已经引入了表达载体，已经引入或破坏其中38594,57312,53659,57502,6760,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和57255alt基因的非人转基因动物。本发明还进一步提供了分离的38594,57312,53659,57250,6360,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和57255alt多肽，融合多肽，抗原肽和抗-38594,57312,53659， 57250,63760,49938,32146,57259,67118,67067,62092，FBH58295FL，57255和57255alt抗体。还提供了利用本发明组合物的诊断和治疗方法。

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