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1. 发明授权

US08911987B2 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US08911987B2
公开(公告)日：2014-12-16
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12Q1/24 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

2. 发明申请

US20100291669A1 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US20100291669A1
公开(公告)日：2010-11-18
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/34
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

3. 发明申请

US20100291619A1 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于培养样品容器的组合检测仪器和用于鉴定和/或表征样品中的微生物剂的仪器
公开(公告)号：US20100291619A1
公开(公告)日：2010-11-18
申请号：US12800467
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

4. 发明授权

US08841118B2 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于培养样品容器的组合检测仪器和用于鉴定和/或表征样品中的微生物剂的仪器
公开(公告)号：US08841118B2
公开(公告)日：2014-09-23
申请号：US12800467
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman C. Thorpe , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman C. Thorpe , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12M1/34 , C12Q1/04 , G01N35/04
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

5. 发明申请

US20100288060A1 Device for sampling a specimen container 有权
标题翻译：用于取样样品容器的装置
公开(公告)号：US20100288060A1
公开(公告)日：2010-11-18
申请号：US12800392
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
IPC分类号： G01N1/12
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.
摘要翻译：用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口在身体中，与腔室流体连通的端口。多个采样装置可以存储在盒中。采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。在该构造中，第二室通过阀等连接到第一室。

6. 发明申请

US20100291618A1 Methods for rapid identification and/or characterization of a microbial agent in a sample 审中-公开
标题翻译：用于快速鉴定和/或表征样品中微生物剂的方法
公开(公告)号：US20100291618A1
公开(公告)日：2010-11-18
申请号：US12800387
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman
IPC分类号： C12Q1/04 , C12Q1/02 , C12N1/00
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically.
摘要翻译：一种测试包含在密封样品容器内的样品样品的方法。用一次性取样装置将样品从样品容器中取出。裂解试验样品的非微生物剂组分，从而产生裂解的样品。裂解的样品被输送到一次性分离装置。存在于试样中的微生物剂集中在一次性分离装置内。浓缩的微生物剂被询问，例如光谱法。

7. 发明授权

US09574219B2 Device for sampling a specimen container 有权
标题翻译：用于取样样品容器的装置
公开(公告)号：US09574219B2
公开(公告)日：2017-02-21
申请号：US12800392
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John Walsh , Jones M. Hyman
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John Walsh , Jones M. Hyman
IPC分类号： G01N1/12 , C12Q1/24 , G01N35/00 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.
摘要翻译：用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口在身体中，与腔室流体连通的端口。多个采样装置可以存储在盒中。采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。在该构造中，第二室通过阀等连接到第一室。

8. 发明授权

US08609024B2 System and method for automatically venting and sampling a culture specimen container 有权
标题翻译：自动排放和取样培养样品容器的系统和方法
公开(公告)号：US08609024B2
公开(公告)日：2013-12-17
申请号：US12800396
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson
IPC分类号： B32B5/02 , G01N35/02
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： Apparatus for automated venting and/or sampling of a specimen container is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device.
摘要翻译：公开了用于自动排放和/或取样试样容器的装置。该装置包括容纳检体容器的架子; 具有针的通气和/或采样装置，与针流体连通的腔室和与腔室流体连通的端口; 相对于机架可移动的机器人传送机构; 附接到机器人传送机构的样品移除装置具有用于夹持排气装置的夹持特征。样品去除装置和机器人传送机构可相对于检体容器移动，从而通过封闭样本容器自动插入排气装置的针头，从而排出样品容器的内部，并获得样品容器和大气，并将样品的一部分从样品容器中取出到排气和/或取样装置中。

9. 外观设计

USD684275S1 Specimen container 有权
标题翻译：标本容器
公开(公告)号：USD684275S1
公开(公告)日：2013-06-11
申请号：US29411700
申请日：2012-01-25
申请人： Mark S. Wilson , Ronnie J. Robinson , Christopher S. Ronsick , Patrick Yerbic , Mark J. Fanning , Stanley M. Philipak
设计人： Mark S. Wilson , Ronnie J. Robinson , Christopher S. Ronsick , Patrick Yerbic , Mark J. Fanning , Stanley M. Philipak

10. 发明申请

US20110081715A1 Single layer plastic test sample culture bottle 审中-公开
标题翻译：单层塑料试样培养瓶
公开(公告)号：US20110081715A1
公开(公告)日：2011-04-07
申请号：US12893161
申请日：2010-09-29
申请人： Ronnie J. Robinson , Christopher S. Ronsick , Mark S. Wilson
发明人： Ronnie J. Robinson , Christopher S. Ronsick , Mark S. Wilson
IPC分类号： C12M1/24 , B05D7/22 , C23C4/06 , H05H1/24
CPC分类号： C12M23/08 , C12M23/20 , C12M23/28
摘要： A bottle for culturing a test sample, e.g., blood, includes a plastic vessel made from a single layer of plastic material. The bottle features a glass barrier coating applied to the bottle, such as a silica or glass coating. An alternative embodiment features a single layer plastic bottle and a gas barrier adhesive label covering the cylindrical side wall of the bottle. Kits comprising two or more of such bottles and methods of manufacturing the bottles are also disclosed.
摘要翻译：用于培养测试样品例如血液的瓶子包括由单层塑料材料制成的塑料容器。该瓶具有施加到瓶子上的玻璃阻隔涂层，例如二氧化硅或玻璃涂层。替代实施例的特征在于单层塑料瓶和覆盖瓶的圆柱形侧壁的阻气粘合标签。还公开了包括这种瓶子中的两种或更多种的瓶子和制造瓶子的方法。

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