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1. 发明申请

US20060234385A1 Polyglutamine repeat sequences 审中-公开
公开(公告)号：US20060234385A1
公开(公告)日：2006-10-19
申请号：US11447733
申请日：2006-06-06
申请人： Ronald Wetzel , Wen Yang , Valerie Berthelier , Songming Chen
发明人： Ronald Wetzel , Wen Yang , Valerie Berthelier , Songming Chen
IPC分类号： G01N33/00 , C07K1/10
CPC分类号： C07K14/00 , C07K1/113 , G01N33/6896 , Y10T436/105831
摘要： Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing polypeptides containing a polyglutamine repeat sequence, for storing these polyglutamine polypeptides and inhibit their spontaneous aggregation, for making the aggregates of polyglutamine polypeptides, for assaying the extension of existing polyglutamine aggregates, for determining the ability of a chemical compound to inhibit aggregation, and for inhibiting aggregation of polyglutamine polypeptides. The invention further provides materials with which to study these diseases including a synthetic aggregate that have a capability to recruit additional monomeric polyglutamine polypeptides and chemical compounds that inhibit the formation and/or extension of polyglutamine aggregates.

2. 发明授权

US07067321B2 Polyglutamine repeat sequences 失效
公开(公告)号：US07067321B2
公开(公告)日：2006-06-27
申请号：US10082673
申请日：2002-02-22
申请人： Ronald Wetzel , Wen Yang , Valerie Berthelier , Songming Chen
发明人： Ronald Wetzel , Wen Yang , Valerie Berthelier , Songming Chen
IPC分类号： G01N33/00
CPC分类号： C07K14/00 , C07K1/113 , G01N33/6896 , Y10T436/105831
摘要： Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing polypeptides containing a polyglutamine repeat sequence, for storing these polyglutamine polypeptides and inhibit their spontaneous aggregation, for making the aggregates of polyglutamine polypeptides, for assaying the extension of existing polyglutamine aggregates, for determining the ability of a chemical compound to inhibit aggregation, and for inhibiting aggregation of polyglutamine polypeptides. The invention further provides materials with which to study these diseases including a synthetic aggregate that have a capability to recruit additional monomeric polyglutamine polypeptides and chemical compounds that inhibit the formation and/or extension of polyglutamine aggregates.

3. 发明申请

US20060079447A1 Stabilized A-beta protofibrillar aggregates 审中-公开
标题翻译：稳定的A-β原纤维聚集体
公开(公告)号：US20060079447A1
公开(公告)日：2006-04-13
申请号：US11245501
申请日：2005-10-07
申请人： Ronald Wetzel
发明人： Ronald Wetzel
IPC分类号： A61K38/17 , A61K31/4164
CPC分类号： A61K38/1709 , A61K31/4164
摘要： Described and claimed herein are methods for producing chemically stabilized Aβ protofibrillar aggregates, and compositions made therefrom. Compositions produced are useful in facilitating detailed studies of Aβ protofibril structure, fibril formation, and progression of Aβ related diseases, e.g., Alzheimers disease. In addition, chemically stabilized protofibrillar structures can be used as tools to generate and/or screen for antibodies specific for protofibrils. Antibodies specific for protofibrils can be used as diagnostic tools or as therapeutics in the diagnosis or treatment of, e.g., Alzheimer's disease. Finally, chemically stabilized protofibrillar structures can be used in the preparation of therapeutic or prophylactic vaccines.
摘要翻译：在此描述和要求的是用于生产化学稳定的Abeta原纤维聚集体的方法和由其制备的组合物。产生的组合物有助于促进Abeta原纤维结构，原纤维形成和Abeta相关疾病例如阿尔茨海默病的进展的详细研究。此外，化学稳定的原纤维结构可用作产生和/或筛选原原纤维特异性抗体的工具。对原原纤维特异的抗体可以用作诊断或治疗例如阿尔茨海默氏病的诊断工具或治疗剂。最后，化学稳定的原纤维结构可用于制备治疗性或预防性疫苗。

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