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1. 发明申请

US20050165106A1 Amidino compounds useful as nitric oxide synthase inhibitors 有权
公开(公告)号：US20050165106A1
公开(公告)日：2005-07-28
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Webber , Richard Durley , Alok Awasthi , Arijia Bergmanis , Kam Fok , Scott Ganser , Timothy Hagen , E. Hallinan , Donald Hansen , Brian Hickory , Pamela Manning , Michael Mao , Alan Moormann , Barnett Pitzele , Michelle Promo , Richard Schartman , Jeffrey Scholten , Jeffrey Snyder , Mihaly Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Tjoeng
发明人： Ronald Webber , Richard Durley , Alok Awasthi , Arijia Bergmanis , Kam Fok , Scott Ganser , Timothy Hagen , E. Hallinan , Donald Hansen , Brian Hickory , Pamela Manning , Michael Mao , Alan Moormann , Barnett Pitzele , Michelle Promo , Richard Schartman , Jeffrey Scholten , Jeffrey Snyder , Mihaly Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Tjoeng
IPC分类号： A61P1/00 , A61K31/198 , A61K31/4166 , A61K31/4245 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P39/02 , A61P43/00 , C07C317/48 , C07C317/50 , C07C323/58 , C07C323/59 , C07D233/76 , C07D271/06 , C07D271/07 , C07D277/56
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

2. 发明授权

US06914158B2 Amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：可用作一氧化氮合酶抑制剂的脒基化合物
公开(公告)号：US06914158B2
公开(公告)日：2005-07-05
申请号：US10815375
申请日：2004-04-01
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61P1/00 , A61K31/198 , A61K31/4166 , A61K31/4245 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P39/02 , A61P43/00 , C07C317/48 , C07C317/50 , C07C323/58 , C07C323/59 , C07D233/76 , C07D271/06 , C07D271/07 , C07D277/56 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译：本发明涉及脒基化合物及其盐和前药。在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。在另一个实施方案中，本发明提供了制备脒基化合物的方法。

3. 发明授权

US07102013B2 Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：制备脒基化合物可用作一氧化氮合酶抑制剂的方法
公开(公告)号：US07102013B2
公开(公告)日：2006-09-05
申请号：US10321969
申请日：2002-12-17
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： C07D233/40 , C07C271/00 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.
摘要翻译：制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。

4. 发明授权

US07196118B2 Amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：可用作一氧化氮合酶抑制剂的脒基化合物
公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译：本发明涉及脒基化合物及其盐和前药。在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。在另一个实施方案中，本发明提供了制备脒基化合物的方法。

5. 发明授权

US06586474B2 Amidino compounds useful as nitric oxide synthase inhibitors 有权
公开(公告)号：US06586474B2
公开(公告)日：2003-07-01
申请号：US09816575
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

6. 发明授权

US07906536B2 Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide 有权
标题翻译：制备3-（4-（2,4-二氟苄氧基）-3-溴-6-甲基-2-氧代吡啶-1（2H） - 基）-N，4-二甲基苯甲酰胺的方法
公开(公告)号：US07906536B2
公开(公告)日：2011-03-15
申请号：US11954883
申请日：2007-12-12
申请人： Daniel Dukesherer , Michael Mao , Richard Vonder Embse , Gopi Yalamanchili , Rajappa Vaidyanathan , Brian Chekal , George Klemm , Ronald VanderRoest , Randy Geurink
发明人： Daniel Dukesherer , Michael Mao , Richard Vonder Embse , Gopi Yalamanchili , Rajappa Vaidyanathan , Brian Chekal , George Klemm , Ronald VanderRoest , Randy Geurink
IPC分类号： A61K31/44
CPC分类号： C07D213/64
摘要： This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4, X5, X6 are as defined in the specification.
摘要翻译：本发明一般涉及制备式I化合物的方法：其中R2，R3，R4，R5，X1，X2，X3，X4，X5，X6如说明书中所定义。

7. 发明授权

US06955454B2 Plasma lamp head 失效
标题翻译：等离子灯头
公开(公告)号：US06955454B2
公开(公告)日：2005-10-18
申请号：US10041284
申请日：2002-01-08
申请人： James Trappani , Patrick Ryan , Steve Handelsman , Michael Mao
发明人： James Trappani , Patrick Ryan , Steve Handelsman , Michael Mao
IPC分类号： B44C5/00 , B44F1/00 , B44F1/06 , F21S8/00 , F21V33/00
CPC分类号： B44F1/00 , B44C5/00 , B44F1/06 , F21W2121/00 , Y10S362/806 , Y10S362/808
摘要： A plasma lamp head that has a spherical plasma bulb whose upper hemisphere serves as the top of the head, a decorative face and lower back of the head covering the lower hemisphere of the bulb. Operative components are provide to enable the bulb to illuminate in response to receipt of appropriate energy delivery to excite the plasma within the bulb to illuminate. The face preferably has eyes, a nose, a mouth and ears, any of which may be transparent or translucent so that light shines through when the bulb illuminates. The remainder of the decorative face and lower back of the head may be opaque or translucent material.
摘要翻译：一种等离子体灯头，其具有球状等离子体灯泡，其上半球用作头部的顶部，头部的装饰面和下背部覆盖灯泡的下半球。提供操作部件以使灯泡响应于接收到适当的能量传递而照亮，以激发灯泡内的等离子体照明。脸部优选具有眼睛，鼻子，嘴和耳朵，其中任何一个可以是透明或半透明的，使得当灯泡照亮时，光线通过。装饰面的其余部分和头部的下背可以是不透明或半透明的材料。

8. 发明申请

US20070261007A1 Graphical Interface for Tree View 有权
标题翻译：树视图的图形界面
公开(公告)号：US20070261007A1
公开(公告)日：2007-11-08
申请号：US11381673
申请日：2006-05-04
申请人： Tracy Hutcheson , Michael Mao , Debra Mayhew
发明人： Tracy Hutcheson , Michael Mao , Debra Mayhew
IPC分类号： G06F3/048
CPC分类号： G06F3/0482
摘要： Various embodiments of a computer-implemented method, system and computer program product provide a graphical interface. At least one tab is presented on a display. The tab comprises one or more child objects of a parent object of a hierarchy of objects. The tab has a three-dimensional effect. The tab has an apparent bend into the display. The apparent bend into the display increases as a depth of the one or more child objects of the hierarchy increases.
摘要翻译：计算机实现的方法，系统和计算机程序产品的各种实施例提供图形界面。至少有一个选项卡显示在显示屏上。选项卡包含对象层次结构的父对象的一个或多个子对象。该标签具有三维效果。该标签在显示屏上有明显的弯曲。随着层次的一个或多个子对象的深度增加，显示器的明显弯曲增加。

9. 发明申请

US20080177077A1 PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE 有权
标题翻译：制备3-（4-（2,4-二氟硼酸）-3-溴-6-甲基-2-氧代吡啶-1（2H） - 基）-N，4-二甲基苯甲酰胺的方法
公开(公告)号：US20080177077A1
公开(公告)日：2008-07-24
申请号：US11954883
申请日：2007-12-12
申请人： Daniel Dukesherer , Michael Mao , Richard Vonder Embse , Gopi Yalamanchili , Rajappa Vaidyanathan , Brian Chekal , George Klemm , Ronald VanderRoset , Randy Geurink
发明人： Daniel Dukesherer , Michael Mao , Richard Vonder Embse , Gopi Yalamanchili , Rajappa Vaidyanathan , Brian Chekal , George Klemm , Ronald VanderRoset , Randy Geurink
IPC分类号： C07D401/02 , C07D213/69
CPC分类号： C07D213/64
摘要： This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4, X5, X6 are as defined in the specification.
摘要翻译：本发明一般涉及制备式I化合物的方法：其中R 2，R 3，R 4，R 4， X 5，X 1，X 2，X 3，X 4，X 4， > 5 ，X 6如说明书中所定义。

10. 发明申请

US20070162891A1 Graphical aid for generating object setup scripts 失效
标题翻译：用于生成对象设置脚本的图形辅助功能
公开(公告)号：US20070162891A1
公开(公告)日：2007-07-12
申请号：US11330832
申请日：2006-01-12
申请人： Dell Burner , Brett Johnson , Yat Lau , Michael Mao , Daina Wickham
发明人： Dell Burner , Brett Johnson , Yat Lau , Michael Mao , Daina Wickham
IPC分类号： G06F9/44 , G06F9/45
CPC分类号： G06F9/45512
摘要： A computer implemented method, data processing system, and computer usable code are provided for automatically generating object setup scripts. A form is presented to a user in a graphical user interface. The user provides input in a set of fields within the form, which is received and validated. A set of object setup scripts are then generated based on the user input to the form. To generate the set of object setup scripts based on the user input an analysis is performed on the set of fields as a set of objects, and at least one variable is set to hold the value of the set of objects. String manipulations are used to obtain the values in the set of fields, and the values are entered into the set of object setup scripts.
摘要翻译：提供计算机实现的方法，数据处理系统和计算机可用代码，用于自动生成对象设置脚本。在图形用户界面中向用户呈现表单。用户在表单内的一组字段中提供输入，这些字段被接收和验证。然后基于用户对表单的输入生成一组对象设置脚本。为了基于用户输入生成一组对象设置脚本，将对集合的字段作为一组对象执行分析，并且至少设置一个变量来保存对象集合的值。字符串操作用于获取字段集中的值，并将值输入到对象设置脚本集中。

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