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1. 发明授权

US06169920A Iontophoretic drug delivery apparatus 失效
公开(公告)号：US06169920A
公开(公告)日：2001-01-02
申请号：US08320387
申请日：1994-10-11
申请人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
发明人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

2. 发明授权

US06317629B1 Iontophoretic drug delivery apparatus 失效
标题翻译：离子电渗药物输送装置
公开(公告)号：US06317629B1
公开(公告)日：2001-11-13
申请号：US08351381
申请日：1994-12-02
申请人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
发明人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.
摘要翻译：提供了一种离子电渗疗法输送装置（10）。设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。装置（10）还包括一对电极组件（18,19）。使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。

3. 发明授权

US5320598A Iontophoretic delivery device and method of hydrating same 失效
公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

4. 发明授权

US5288289A Iontophoretic delivery device and method of hydrating same 失效
标题翻译：离子渗透输送装置及其水合方法
公开(公告)号：US5288289A
公开(公告)日：1994-02-22
申请号：US881909
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).
摘要翻译：提供了干态离子电渗药物输送装置（10,70,80）。该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。提供含液囊（21,22）。在某些实施方案中，液体包含在小袋内的可破坏胶囊中。水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。或者，可以使用袋刺穿销（36,37）从袋（21,22）释放液体。从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

5. 发明授权

US5158537A Iontophoretic delivery device and method of hydrating same 失效
标题翻译：静电输送装置及其液压方法
公开(公告)号：US5158537A
公开(公告)日：1992-10-27
申请号：US605046
申请日：1990-10-29
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).
摘要翻译：提供了干态离子电渗药物输送装置（10,70,80）。该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。提供含液囊（21,22）。在某些实施方案中，液体包含在小袋内的可破坏胶囊中。水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。或者，可以使用袋刺穿销（36,37）从袋（21,22）中释放液体。从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

6. 发明授权

US5993435A Device and method of iontophoretic drug delivery 失效
标题翻译：离子电渗药物递送的装置和方法
公开(公告)号：US5993435A
公开(公告)日：1999-11-30
申请号：US139036
申请日：1998-08-24
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448 , A61N1/0436
摘要： A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
摘要翻译：选择性渗透膜（14）位于药剂储存器（15）和离子电渗输送装置（10）中的施主电极组件（8）的电极（11）之间。可选地，电解质储存器（13）位于电极（11）和药剂储存器（15）之间。在某些实施方案中，膜（14）对于小于预定分子量的物质是可渗透的，并且对于大于预定分子量的物质基本上较不可渗透。该试剂能够解离成试剂离子和抗衡离子。选择膜（14）的尺寸选择性，试剂离子的分子量，抗衡离子的分子量和任选的电解质离子的分子量以使（A）抑制剂离子与电极相互作用（ 11），并且从渗透到电解质储存器（13）中，否则可能会降解，并且（B）抑制具有类似于试剂离子的电荷的电解质离子渗透到试剂储存器（15）中并且竞争用离子电渗疗法输送到患者体内。

7. 发明授权

US5496266A Device and method of iontophoretic drug delivery 失效
标题翻译：离子电渗药物递送的装置和方法
公开(公告)号：US5496266A
公开(公告)日：1996-03-05
申请号：US941421
申请日：1992-10-27
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448 , A61N1/0436
摘要： A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
摘要翻译： PCT No.PCT / US90 / 02414 Sec。 371日期：1992年10月27日 102（e）1992年10月27日的PCT日期1990年4月30日PCT。选择性渗透膜（14）位于药剂储存器（15）和施主电极组件（8）的电极（11）之间，离子电渗输送装置（10）。可选地，电解质储存器（13）位于电极（11）和药剂储存器（15）之间。在某些实施方案中，膜（14）对于小于预定分子量的物质是可渗透的，并且对于大于预定分子量的物质基本上较不可渗透。该试剂能够解离成试剂离子和抗衡离子。选择膜（14）的尺寸选择性，试剂离子的分子量，抗衡离子的分子量和任选的电解质离子的分子量以使（A）抑制剂离子与电极相互作用（ 11），并且从渗透到电解质储存器（13）中，否则可能会降解，并且（B）抑制具有类似于试剂离子的电荷的电解质离子渗透到试剂储存器（15）中并且竞争用离子电渗疗法输送到患者体内。

8. 发明授权

US6163720A Layered rate controlling membranes for use in an electrotransport device 有权
标题翻译：用于电输送装置的分层速率控制膜
公开(公告)号：US6163720A
公开(公告)日：2000-12-19
申请号：US204820
申请日：1998-12-03
申请人： J. Richard Gyory , Ronald P. Haak
发明人： J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： The disclosed invention relates to an improved electrotransport device. The improvement relates to a membrane assembly including a low porosity membrane adhered or sealed to one or two high porosity membranes. The high porosity membranes protect the low porosity membrane from being damaged by components or contaminates on the body surface and/or in the drug reservoir which can lead to undesirable passive flux and/or insufficient iontophoretic flux. As a result, the electrotransport device having the membrane assembly more reliably, precisely, and accurately delivers drug and/or therapeutic agent through the body surface by electrotransport.
摘要翻译：所公开的发明涉及一种改进的电输送装置。该改进涉及一种膜组件，其包括粘附或密封到一个或两个高孔隙率膜的低孔隙率膜。高孔隙率膜保护低孔隙率膜不被身体表面上和/或药物储存器中的组分或污染物损坏，这可能导致不期望的被动通量和/或不充分的离子电渗通量。结果，具有膜组件的电输送装置通过电传输更可靠，精确和精确地输送药物和/或治疗剂通过身体表面。

9. 发明授权

US5232438A Membrane for electrotransport transdermal drug delivery 失效
标题翻译：用于电转运透皮药物递送的膜
公开(公告)号：US5232438A
公开(公告)日：1993-08-03
申请号：US898618
申请日：1992-06-15
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0444
摘要： A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
摘要翻译：一种膜，当没有电流流动时能够抑制剂量从递送系统释放，并且对电辅助剂递送提供最小的阻抗，对于并入电转运剂递送系统和用于体外测定中的测定剂释放速率是有用的。

10. 发明授权

US5203768A Transdermal delivery device 失效
标题翻译：超传送装置
公开(公告)号：US5203768A
公开(公告)日：1993-04-20
申请号：US735126
申请日：1991-07-24
申请人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
发明人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
IPC分类号： A61K9/00 , A61N1/30
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
摘要翻译：提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

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