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1. 发明授权

US5445606A Indicator for iontophoresis system 失效
标题翻译：离子电渗系统指示剂
公开(公告)号：US5445606A
公开(公告)日：1995-08-29
申请号：US69061
申请日：1993-05-28
申请人： Ronald P. Haak , Felix Theeuwes , David K. Roe
发明人： Ronald P. Haak , Felix Theeuwes , David K. Roe
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0448 , A61N1/325 , A61N1/0436 , A61N1/044
摘要： Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and displaying the cumulative amount of the medicament delivered to the body by monitoring the amount of a metal, initially present at the anode (45), that is transferred to the cathode (41) in a subsidiary electrolyte cell (47) through which the drive current for the apparatus (11) passes. Optionally, the apparatus also provides a plurality of light emitting devices (63-1) that display a measure of the cumulative amount of medicament delivered, by use of visually distinguishable light colors or by use of binary encoding in the light display.
摘要翻译：提供了用于通过离子电渗法将药物，药物或其它治疗剂透皮地递送到身体的装置（11）。装置（11）提供了一种装置（13），用于通过监测最初存在于阳极（45）的金属的量来测量和显示递送到身体的药物的累积量，该金属的量转移到阴极（41））连接在辅助电解质电池（47）中，用于装置（11）的驱动电流通过该辅助电解质电池（47）。可选地，该装置还提供多个发光装置（63-1），其通过使用视觉上可区分的光色或通过在光显示器中使用二进制编码来显示传送的药物的累积量的量度。

2. 发明授权

US5246417A Indicator for iontophoresis system 失效
标题翻译：指示系统
公开(公告)号：US5246417A
公开(公告)日：1993-09-21
申请号：US806055
申请日：1991-12-11
申请人： Ronald P. Haak , Felix Theeuwes , David K. Roe
发明人： Ronald P. Haak , Felix Theeuwes , David K. Roe
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0448 , A61N1/325 , A61N1/0436 , A61N1/044
摘要： Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and displaying the cumulative amount of the medicament delivered to the body by monitoring the amount of a metal, initially present at the anode (45), that is transferred to the cathode (41) in a subsidiary electrolyte cell (47) through which the drive current for the apparatus (11) passes. Optionally, the apparatus also provides a plurality of light emitting devices (63-1) that display a measure of the cumulative amount of medicament delivered, by use of visually distinguishable light colors or by use of binary encoding in the light display.
摘要翻译：提供了用于通过离子电渗法将药物，药物或其它治疗剂透皮地递送到身体的装置（11）。装置（11）提供了一种装置（13），用于通过监测最初存在于阳极（45）的金属的量来测量和显示递送到身体的药物的累积量，该金属的量转移到阴极（41））连接在辅助电解质电池（47）中，用于装置（11）的驱动电流通过该辅助电解质电池（47）。可选地，该装置还提供多个发光装置（63-1），其通过使用视觉上可区分的光色或通过在光显示器中使用二进制编码来显示传送的药物的累积量的量度。

3. 发明授权

US07212853B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07212853B1
公开(公告)日：2007-05-01
申请号：US08952368
申请日：1996-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

4. 发明授权

US5232438A Membrane for electrotransport transdermal drug delivery 失效
标题翻译：用于电转运透皮药物递送的膜
公开(公告)号：US5232438A
公开(公告)日：1993-08-03
申请号：US898618
申请日：1992-06-15
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0444
摘要： A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
摘要翻译：一种膜，当没有电流流动时能够抑制剂量从递送系统释放，并且对电辅助剂递送提供最小的阻抗，对于并入电转运剂递送系统和用于体外测定中的测定剂释放速率是有用的。

5. 发明授权

US5203768A Transdermal delivery device 失效
标题翻译：超传送装置
公开(公告)号：US5203768A
公开(公告)日：1993-04-20
申请号：US735126
申请日：1991-07-24
申请人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
发明人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
IPC分类号： A61K9/00 , A61N1/30
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
摘要翻译：提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

6. 发明授权

US06718201B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US06718201B1
公开(公告)日：2004-04-06
申请号：US08952367
申请日：1997-11-17
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport device and method of operating same provides a pulsed DC current of specified frequency and duration which transforms the skin into a higher electrotransport delivery efficiency state.
摘要翻译：电输送装置及其操作方法提供指定频率和持续时间的脉冲直流电流，其将皮肤转变成更高的电输送输送效率状态。

7. 发明授权

US5320598A Iontophoretic delivery device and method of hydrating same 失效
公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

8. 发明授权

US5298017A Layered electrotransport drug delivery system 失效
标题翻译：分层电运输药物输送系统
公开(公告)号：US5298017A
公开(公告)日：1994-03-29
申请号：US998154
申请日：1992-12-29
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially suited to agent delivery through body surfaces exposed to body fluids. A method of delivering an agent through a body surface exposed to body fluids is also disclosed.
摘要翻译：一种具有分层结构和外围绝缘的离子电渗疗剂输送装置，其中通过所述装置的两个相对的表面进行离子转运。该装置特别适用于通过暴露于体液的身体表面的药剂递送。还公开了通过暴露于体液的身体表面递送药剂的方法。

9. 发明授权

US5169383A Control membrane for electrotransport drug delivery 失效
标题翻译：电转运药物控制膜
公开(公告)号：US5169383A
公开(公告)日：1992-12-08
申请号：US571577
申请日：1990-09-07
申请人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
发明人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
IPC分类号： A61J1/20 , A61M37/00 , A61N20060101 , A61N1/30
CPC分类号： A61N1/0444 , A61N1/044
摘要： A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no electrical current is flowing and yet provides minimal impedance to electrically-assisted agent delivery. The membrane is useful both as a control membrane in an iontophoretic agent delivery device and as a test membrane for testing the performance characteristics of an iontophoretic agent delivery device in vitro.
摘要翻译： PCT No.PCT / US89 / 04318 Sec。 371 1990年9月7日第 102（e）1990年9月7日PCT PCT 1989年10月2日PCT公布。出版物WO90 / 0382500 日本1990年04月19日提供了能够控制药剂从离子电渗输送装置中释放的速率的膜。当没有电流流动时，该膜抑制剂量从输送装置释放，并且对电辅助剂递送提供最小的阻抗。膜可用作离子电渗剂递送装置中的对照膜以及用于在体外测试离子电渗疗法递送装置的性能特征的测试膜。

10. 发明授权

US07572252B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07572252B1
公开(公告)日：2009-08-11
申请号：US08484934
申请日：1995-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
IPC分类号： A61M31/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0014 , A61K9/06 , A61K31/4468 , A61M2037/0007 , A61N1/30
摘要： A method of increasing the delivery efficiency of an agent through a body surface by electrotransport is disclosed wherein the electrotransport current is applied for durations at a higher current density values followed by durations of lower current density values wherein the higher current density applications transform the body surface to an enhanced, non-transitory agent delivery efficiency state.
摘要翻译：公开了一种通过电运输提高试剂通过身体表面的输送效率的方法，其中电传输电流以较高电流密度值施加持续时间，随后是较低电流密度值的持续时间，其中较高的电流密度应用转变体表面以增强，非临时代理分配效率状态。

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