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1. 发明申请

US20070092978A1 Target ligand detection 审中-公开
标题翻译：靶配体检测
公开(公告)号：US20070092978A1
公开(公告)日：2007-04-26
申请号：US11254975
申请日：2005-10-20
申请人： Ronald Mink , Toby Gottfried , John Ennis , Paul Smith , Glen Ford
发明人： Ronald Mink , Toby Gottfried , John Ennis , Paul Smith , Glen Ford
IPC分类号： G01N33/543
CPC分类号： G01N33/54353
摘要： The present invention provides compositions, devices and methods suitable for the increased sensitivity and selectivity of binding assays thereby reducing false positive results without little or no reduction in the detection of true positives. The present invention is based on the novel discovery that an oxidative agent in the context of the device of the present invention results in decreased false positive reactivity with little or no reduction in true positive reactivity. The devices, compositions and methods of the present invention may be used, for example, to detect pathogens giving rise to endogenous urine antibodies include those organisms known to be causative agents in sexually-transmitted diseases and other diseases. The devices and methods of the present invention are also useful for various diagnostic procedures.
摘要翻译：本发明提供了适合增加结合测定的灵敏度和选择性的组合物，装置和方法，从而减少假阳性结果，而没有或没有减少真阳性的检测。本发明基于这样的新发现：在本发明的装置的上下文中的氧化剂导致假阳性反应性降低，很少或没有真正阳性反应性的降低。本发明的装置，组合物和方法可以用于例如检测引起内源性尿抗体的病原体，包括已知在性传播疾病和其他疾病中是致病因子的那些生物体。本发明的装置和方法也可用于各种诊断程序。

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