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1. 发明申请

US20050107403A1 Aminopyrimidine and aminopyridine anti-inflammation agents 失效
标题翻译：氨基嘧啶和氨基吡啶抗炎剂
公开(公告)号：US20050107403A1
公开(公告)日：2005-05-19
申请号：US10967430
申请日：2004-10-18
申请人： Ronald Hawley , Sharada Labadie , Eric Sjogren , Francisco Talamas
发明人： Ronald Hawley , Sharada Labadie , Eric Sjogren , Francisco Talamas
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P1/04 , A61P3/10 , A61P17/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D43/02 , A61K31/513
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.
摘要翻译：本文提供氨基嘧啶和氨基吡啶（I）化合物，用于治疗炎症，代谢或恶性疾病的组合物和方法。

2. 发明申请

US20050043330A1 Antiinflammation agents 失效
公开(公告)号：US20050043330A1
公开(公告)日：2005-02-24
申请号：US10928784
申请日：2004-08-26
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K31/519 , A61K31/517 , C07D487/02 , C07D43/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

3. 发明申请

US20070135464A1 Antiinflammation agents 审中-公开
公开(公告)号：US20070135464A1
公开(公告)日：2007-06-14
申请号：US11650268
申请日：2007-01-05
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/519 , A61K31/4709 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

4. 发明申请

US20060252784A1 Imidazo-substituted compounds as P38 kinase inhibitors 失效
标题翻译：咪唑取代的化合物作为P38激酶抑制剂
公开(公告)号：US20060252784A1
公开(公告)日：2006-11-09
申请号：US11486348
申请日：2006-07-13
申请人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
发明人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
IPC分类号： C07D487/14 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
摘要翻译：本发明公开了对应于式I的化合物：其中A，Z，Z 1，Y，R 1和R 2定义如说明书以及药物制剂，制备方法和用途。

5. 发明申请

US20060252783A1 Imidazo-substituted compounds as p38 kinase inhibitors 失效
公开(公告)号：US20060252783A1
公开(公告)日：2006-11-09
申请号：US11486193
申请日：2006-07-13
申请人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
发明人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
IPC分类号： C07D487/14 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.

6. 发明申请

US20050197352A1 Imidazo-substituted compounds as p38 kinase inhibitors 失效
公开(公告)号：US20050197352A1
公开(公告)日：2005-09-08
申请号：US11122137
申请日：2005-05-04
申请人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
发明人： David Goldstein , Ronald Hawley , Alfred Lui , Eric Sjogren
IPC分类号： A61P11/00 , A61P25/00 , A61P29/00 , C07D471/14 , C07D487/14 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.

7. 发明授权

US07476727B2 Conjugates of mycophenolic acid 失效
标题翻译：霉酚酸的结合物
公开(公告)号：US07476727B2
公开(公告)日：2009-01-13
申请号：US11673180
申请日：2007-02-09
申请人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
IPC分类号： C07G3/00 , C07H15/20 , C07D233/00 , C07D473/00 , C07D211/72
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

8. 发明申请

US20050009076A1 Enzyme inhibition immunoassay 失效
标题翻译：酶抑制免疫测定
公开(公告)号：US20050009076A1
公开(公告)日：2005-01-13
申请号：US10900447
申请日：2004-07-27
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94 , C12Q1/68 , C07H15/24 , C07H21/04 , C07J17/00
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

9. 发明申请

US20080048465A1 Device and Method for Extending Truck Cargo Space 失效
标题翻译：扩大货车空间的装置和方法
公开(公告)号：US20080048465A1
公开(公告)日：2008-02-28
申请号：US11843037
申请日：2007-08-22
申请人： Ronald Hawley
发明人： Ronald Hawley
IPC分类号： B62D33/08
CPC分类号： B62D33/0273
摘要： The present invention extends the truck bed, thus increasing cargo space by the length of the truck tailgate. One embodiment of the invention comprises rotatably attaching an end panel to the tailgate, with rotatable and storable support members. Another embodiment comprises right and left side panels rotatably attached to the end panel. When the assembly is stored, either the support members or the side panels are rotated inward to rest against the inner surface of the end panel and the end panel is rotated downwardly and secured against the upper surface of the tailgate. When the assembly is deployed, the end panel is unsecured from the tailgate and is rotated upwardly until approximately perpendicular with the tailgate and the cargo space bed. The support members or side panels are rotated outwardly and secured to complete deployment. In certain embodiments, the end panel may be removed easily and quickly, or lowered down and out of the way, to allow and facilitate loading of longer items in the cargo space, and then reattached and deployed. The mounting bracket and/or end panel may comprise molded reinforced plastic composite material.
摘要翻译：本发明延伸了卡车底盘，从而将货物空间增加了卡车尾门的长度。本发明的一个实施例包括以可旋转和可存储的支撑构件将端板可旋转地附接到后挡板。另一个实施例包括可旋转地附接到端板的右侧板和左侧板。当组件被存储时，支撑构件或侧板向内旋转以抵靠端板的内表面，并且端板向下旋转并固定在后挡板的上表面上。当组件部署时，端板不受后挡板的影响，并向上旋转直到大约垂直于后挡板和货物空间床。支撑构件或侧板向外旋转并固定以完全展开。在某些实施例中，可以容易地，快速地或者降下端面板去除端面板，以允许并便于在货物空间中装载更长的物品，然后重新附接和展开。安装支架和/或端板可以包括模制的增强塑料复合材料。

10. 发明申请

US20090096236A1 TRUCK BED RACK 审中-公开
标题翻译：卡车车架
公开(公告)号：US20090096236A1
公开(公告)日：2009-04-16
申请号：US12212895
申请日：2008-09-18
申请人： Ronald Hawley
发明人： Ronald Hawley
IPC分类号： B60P3/40 , A47F7/00
CPC分类号： B60R9/00 , B60P3/40 , B60R9/0485
摘要： The present invention comprises various embodiments of a rack that is adapted for the bed of a pickup truck for securing ramps, ladders and the like. The rack comprises two spaced apart vertical support members. Each vertical support member comprises two spaced apart U-support assemblies. Each of the resulting four U-support assemblies are independently and slidably adjustable relative to the other U-support assemblies. In the preferred embodiment, the slidable adjustment capabilities of the U-support assemblies comprises infinite adjustability. Thus, the present invention allows for securing ramps, ladders and the like having varying widths.
摘要翻译：本发明包括适于用于固定斜坡，梯子等的皮卡车床的齿条的各种实施例。机架包括两个间隔开的垂直支撑构件。每个垂直支撑构件包括两个间隔开的U形支撑组件。所得到的四个U形支撑组件中的每一个相对于其它U形支撑组件独立且可滑动地调节。在优选实施例中，U型支撑组件的可滑动调整能力包括无限可调性。因此，本发明允许固定具有不同宽度的斜面，梯子等。

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