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1. 发明授权

US07300782B2 Glycosyl hydrolases 有权
标题翻译：糖基水解酶
公开(公告)号：US07300782B2
公开(公告)日：2007-11-27
申请号：US10872874
申请日：2004-06-21
申请人： Roland Breves , Karl-Heinz Maurer , Jürgen Eck , Patrick Lorenz , Holger Zinke
发明人： Roland Breves , Karl-Heinz Maurer , Jürgen Eck , Patrick Lorenz , Holger Zinke
IPC分类号： C12N9/24 , C12N9/00 , C11D3/386 , C07K1/00 , C07H21/04
CPC分类号： C12N9/2414 , C07K2319/00 , C11D3/386 , Y02E50/17
摘要： The invention relates to a new glycosyl hydrolases with an amyloltic activity and nucleic acids coding for said gylcosyl hydrolases, A PCR-based method for identifying and preparing new gylcosyl hydrolases from metagenome DNA and several possible technical uses for such glycosyl hydrolases with an amylolytic activity. Washing and cleaning products containing such enzymes, and methods and possible uses corresponding thereto are particularly interesting.
摘要翻译：本发明涉及具有淀粉分解活性的新糖基水解酶和编码所述格基糖基水解酶的核酸，基于PCR的从宏基因组DNA鉴定和制备新的糖基水解酶的方法以及具有淀粉分解活性的这种糖基水解酶的几种可能的技术用途。含有这些酶的洗涤和清洁产品，以及与其对应的方法和可能的用途是特别有趣的。

2. 发明授权

US06271368B1 Recombinant mistletoe lectin (rML) 失效
标题翻译：重组槲寄生凝集素（rML）
公开(公告)号：US06271368B1
公开(公告)日：2001-08-07
申请号：US08776059
申请日：1997-06-19
申请人： Hans Lentzen , Jürgen Eck , Axel Baur , Holger Zinke
发明人： Hans Lentzen , Jürgen Eck , Axel Baur , Holger Zinke
IPC分类号： C12N121
CPC分类号： C07K14/42 , A61K38/00 , A61K47/6819 , C07K2319/00
摘要： The invention relates to nucleic acid molecules encoding preproproteins having after maturation the biological activity of the mistletoe lectin dimer, to vectors comprising these nucleic acid molecules, to hosts transformed with said vectors and to polypeptides and/or polypeptide dimers which are encoded by these nucleic acid molecules. The polypeptides and/or polypeptide dimers of the invention are widely therapeutically applicable. Thus, the present invention further relates to immunotoxins as well as to pharmaceutical compositions that contain the polypeptides and/or the polypeptide dimers of the invention. Additionally, the invention relates to diagnostic compositions comprising the nucleic acid molecules of the invention, the polypeptides and/or the polypeptide dimers of the invention and/or primers which hybridize specifically to the nucleic acid molecules of the invention. Finally, the invention relates to plant protective agents comprising the polypeptides of the invention and/or the polypeptide dimers of the invention.
摘要翻译：本发明涉及将成熟后槲皮素凝集素二聚体的生物活性的前蛋白质，包含这些核酸分子的载体转染到用所述载体转化的宿主的核酸分子和由这些核酸编码的多肽和/或多肽二聚体分子。本发明的多肽和/或多肽二聚体在广泛的治疗上是适用的。因此，本发明还涉及免疫毒素以及含有本发明的多肽和/或多肽二聚体的药物组合物。另外，本发明涉及包含本发明的核酸分子，本发明的多肽和/或多肽二聚体的诊断组合物和/或与本发明的核酸分子特异性杂交的引物。最后，本发明涉及包含本发明的多肽和/或本发明的多肽二聚体的植物保护剂。

3. 发明授权

US07700311B2 Alcohol dehydrogenases 有权
标题翻译：酒精脱氢酶
公开(公告)号：US07700311B2
公开(公告)日：2010-04-20
申请号：US10593119
申请日：2005-03-10
申请人： Renate Schulze , Patrick Lorenz , Jürgen Eck , Oliver May , Harald Gröger , Harald Trauthwein
发明人： Renate Schulze , Patrick Lorenz , Jürgen Eck , Oliver May , Harald Gröger , Harald Trauthwein
IPC分类号： C12Q1/26 , C12N9/02
CPC分类号： C12P7/02 , C12N9/0006 , C12Y101/01002
摘要： The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to nonhuman hosts or host cells and to reaction systems which may be used for preparing desired products. The polypeptides of the invention are preferably used in the preparation, starting from aldehydes or ketones, of primary and enantiomerically pure secondary alcohols which may serve as intermediates for medicaments. Alternatively, the polypeptides of the invention may also be employed in the reverse reaction, i.e. the oxidation of alcohols with the formation of aldehydes or ketones.
摘要翻译：本发明涉及具有NAD-或NADP依赖性醇脱氢酶的生物活性的新型多肽。本发明还涉及编码所述多肽的核酸，非人宿主细胞和宿主细胞以及可用于制备所需产物的反应体系。本发明的多肽优选用于从醛或酮开始制备可用作药物中间体的伯和对映体纯的仲醇。或者，本发明的多肽也可以用于逆反应，即醇形成醛或酮的氧化。

4. 发明授权

US07749366B2 Isolation and cloning of DNA from uncultivated organisms 失效
标题翻译：从未培养的生物体中分离和克隆DNA
公开(公告)号：US07749366B2
公开(公告)日：2010-07-06
申请号：US10525708
申请日：2003-08-20
申请人： Achim Quaiser , Torsten Ochsenreiter , Alexander H. Treusch , Arnulf Kletzin , Christa Schleper , Patrick Lorenz , Jürgen Eck
发明人： Achim Quaiser , Torsten Ochsenreiter , Alexander H. Treusch , Arnulf Kletzin , Christa Schleper , Patrick Lorenz , Jürgen Eck
IPC分类号： G01N33/559 , C40B60/10 , C12M1/00
CPC分类号： C12N15/1003
摘要： The present invention relates to a device for the isolation and/or purification of nucleic acid molecules suitable to bind and/or inactivate inhibitors of the activity of reagents or enzymes used for DNA manipulation and to separate a plurality of nucleic acid molecules with respect to their size. Moreover, the invention relates to a method for the isolation of a nucleic acid molecule comprising applying a sample to the device of the invention wherein said nucleic acid molecule preferably represents a fraction of the metagenome of a given habitat. Furthermore, the invention relates to a method for the generation of at least one gene library comprising nucleic acid molecules isolated by the method of the invention and to a nucleic acid molecule isolated by the method of the invention.
摘要翻译：本发明涉及用于分离和/或纯化适于结合和/或失活用于DNA操作的试剂或酶的活性抑制剂的核酸分子的装置，并且相对于它们分离多个核酸分子尺寸。此外，本发明涉及用于分离核酸分子的方法，包括将样品施用于本发明的装置，其中所述核酸分子优选代表给定栖息地的元素的一部分。此外，本发明涉及产生至少一种包含通过本发明方法分离的核酸分子的基因文库以及通过本发明的方法分离的核酸分子的方法。

5. 发明申请

US20110268792A1 SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 有权
标题翻译：表面活性蛋白作为固体药物制剂的优点
公开(公告)号：US20110268792A1
公开(公告)日：2011-11-03
申请号：US13130128
申请日：2009-11-13
申请人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
发明人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
IPC分类号： A61K9/48 , A61P39/00 , A61K9/16 , A61K9/02 , A61K9/00 , A61K9/38
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译：本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如，作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。用于本发明目的的表面活性蛋白质可以从它们各自的天然来源中分离或者通过重组技术制备并在合适的宿主中表达。

6. 发明授权

US08226967B2 Surface active proteins as excipients in solid pharmaceutical formulations 有权
标题翻译：表面活性蛋白作为固体药物制剂中的赋形剂
公开(公告)号：US08226967B2
公开(公告)日：2012-07-24
申请号：US13130128
申请日：2009-11-13
申请人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
发明人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
IPC分类号： A01N25/34 , C07K1/00
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译：本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如，作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。用于本发明目的的表面活性蛋白质可以从其各自的天然来源分离或通过重组技术制备并在合适的宿主中表达。

7. 发明申请

US20100047863A1 GROUP OF NOVEL ENANTIOSLEECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY 失效
标题翻译：具有广泛基质特征的新型强化微生物氮化物组
公开(公告)号：US20100047863A1
公开(公告)日：2010-02-25
申请号：US12296057
申请日：2007-04-05
申请人： Jürgen Eck , Klaus Liebeton , Lutz Fischer , Sabine Lutz-Wahl , Martina Hensel , Christian Ewert , Marcus Wälz
发明人： Jürgen Eck , Klaus Liebeton , Lutz Fischer , Sabine Lutz-Wahl , Martina Hensel , Christian Ewert , Marcus Wälz
IPC分类号： C12P21/06 , C12P13/02 , C12N15/74 , C12N1/21 , C12N15/63 , C07K14/00 , C07K16/00 , C07H21/04
CPC分类号： C12N9/88 , C12P13/02 , C12P41/006
摘要： The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitrites.
摘要翻译：本发明提供了编码具有腈水合酶（NHase）[E.C.]的酶的多核苷酸或一对多核苷酸。 4.2.1.84]活动。此外，提供了包含所公开的多核苷酸或一对多核苷酸的载体和宿主及其生产方法。此外，本发明涉及一对多肽或具有NHase活性的融合蛋白，特异性结合所述一对多肽或融合蛋白的抗体，在严格条件下与所公开的多核苷酸特异性杂交的引物或探针，或者一对多核苷酸，包含多核苷酸或一对多核苷酸的组合物，一对多肽或融合蛋白，本发明的抗体和/或一种或多种引物或探针以及生产酰胺的方法，其包括对映选择性转化亚硝酸盐

8. 发明授权

US07635567B2 Method for determination of the responsiveness of an individual to mistletoe lectin 失效
标题翻译：确定个体对槲寄生凝集素的反应性的方法
公开(公告)号：US07635567B2
公开(公告)日：2009-12-22
申请号：US10499297
申请日：2002-12-20
申请人： Johannes Müthing , Jasna Peter-Katalinic , Martin Langer , Babette Möckel , Jürgen Eck
发明人： Johannes Müthing , Jasna Peter-Katalinic , Martin Langer , Babette Möckel , Jürgen Eck
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： C12Q1/48 , C07K16/18 , G01N33/566 , G01N33/66 , G01N2333/42 , G01N2400/00 , G01N2800/52
摘要： A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for mistletoe lectin is characteristic of a corresponding responsiveness.
摘要翻译：用于测定个体对槲寄生凝集素或（一种）槲寄生凝集素单链的响应性的方法，其中槲寄生凝集素的膜结合受体的表达是相应的响应性的特征。

9. 发明授权

US09353386B2 Means and methods for producing propanediol 有权
标题翻译：制备丙二醇的方法和方法
公开(公告)号：US09353386B2
公开(公告)日：2016-05-31
申请号：US14125409
申请日：2012-06-15
申请人： Daniel Koch , Guido Meurer , Jürgen Eck
发明人： Daniel Koch , Guido Meurer , Jürgen Eck
IPC分类号： C12P7/24 , C12P7/18 , C12N9/04 , C12N9/02 , C12N9/10
CPC分类号： C12P7/24 , C12N9/0006 , C12N9/0008 , C12N9/13 , C12P7/18 , C12Y101/01077 , C12Y102/01 , C12Y208/03001 , Y02P20/52
摘要： The present invention relates to a host cell having an elevated expression or activity of an enzyme as compared with the parent cell from which it has been derived, said enzyme having lactoyl-CoA reductase activity. Furthermore, provided is a method of producing lactaldehyde and/or 1,2-propanediol, said method comprising culturing said host cell and/or utilizing said enzyme to produce said compound.
摘要翻译：本发明涉及一种具有升高的酶表达或活性的宿主细胞，与其衍生的亲本细胞相比，所述酶具有乳酰基-CoA还原酶活性。此外，提供了生产乳醛和/或1,2-丙二醇的方法，所述方法包括培养所述宿主细胞和/或利用所述酶产生所述化合物。

10. 发明授权

US08993743B2 Chimeric surface active proteins 有权
标题翻译：嵌合表面活性蛋白
公开(公告)号：US08993743B2
公开(公告)日：2015-03-31
申请号：US13579910
申请日：2011-02-18
申请人： Guido Meurer , Esther Gabor , Anke Bachert , Jürgen Eck
发明人： Guido Meurer , Esther Gabor , Anke Bachert , Jürgen Eck
IPC分类号： C07H21/04 , C07K14/37 , C12N15/62 , A61K9/28 , C09D189/00
CPC分类号： C07K14/37 , A61K9/286 , A61K9/2873 , C09D189/00 , C12N15/62
摘要： The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.
摘要翻译：本发明涉及编码具有表面活性蛋白的生化活性的嵌合蛋白的核酸分子，其中所述嵌合蛋白包含：（a）第一表面活性蛋白的N末端部分，其中所述N末端部分没有成熟的第一表面活性蛋白的最多N末端氨基酸的0和10之间; 并且其C末端，（b）第二表面活性蛋白质的C末端部分，其中所述C末端部分缺少所述成熟第二表面活性蛋白质的最C末端氨基酸的0至10个。本发明还涉及载体，非人宿主和生产具有表面活性蛋白的生化活性的嵌合蛋白的方法。此外，本发明涉及由本发明的核酸分子编码的嵌合蛋白质和包含该嵌合蛋白质的组合物。嵌合蛋白质只能由上述（a）和（b）的核心组成，但也可以由核心的另外的组分，即（a）或（b）或另外一个完整的核心）（a）和（b）。本发明还涉及一种涂覆和/或浸渍材料的方法，包括使材料与本发明的嵌合蛋白或组合物接触。

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