专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08986988B2 Cell rolling separation 有权
标题翻译：电解槽分离
公开(公告)号：US08986988B2
公开(公告)日：2015-03-24
申请号：US12680249
申请日：2008-09-29
申请人： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
发明人： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
IPC分类号： C12N5/07 , C12N5/00 , C12N5/0735 , C12N5/078 , C12M1/00
CPC分类号： C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
摘要翻译：本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。公开了涂覆区域和边缘的各种设计。

2. 发明授权

US08450298B2 Aminoalcohol lipidoids and uses thereof 有权
公开(公告)号：US08450298B2
公开(公告)日：2013-05-28
申请号：US12716732
申请日：2010-03-03
申请人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K38/00
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

3. 再颁专利

USRE43612E1 Biodegradable poly(β-amino esters) and uses thereof 有权
标题翻译：可生物降解的聚（β-氨基酯）及其用途
公开(公告)号：USRE43612E1
公开(公告)日：2012-08-28
申请号：US12568481
申请日：2009-09-28
申请人： Daniel Griffith Anderson , David M. Lynn , Akin Akinc , Robert S. Langer
发明人： Daniel Griffith Anderson , David M. Lynn , Akin Akinc , Robert S. Langer
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： C12N15/88 , A61K9/1641 , A61K9/5146 , A61K47/59 , A61K47/593 , A61K47/6935 , B82Y5/00 , C08G73/02 , C08G73/06 , C08G73/0611 , C08G73/0616 , C08G73/0627
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
摘要翻译：描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（＆（bgr。 - 氨基酯））。还提供了从市售的原料制备这些聚合物的方法。这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。本发明的聚合物也可以用于包封待递送的其它试剂。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。还提供了使用半自动机器人流体输送系统并行制备和筛选聚合物的系统。

4. 发明授权

US08969353B2 Aminoalcohol lipidoids and uses thereof 有权
标题翻译：氨基醇类固醇及其用途
公开(公告)号：US08969353B2
公开(公告)日：2015-03-03
申请号：US13128020
申请日：2009-11-06
申请人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K31/495 , C07D241/04 , A61K9/127 , A61K47/16 , C07C215/14 , C12N15/11 , C07C217/08 , A61K9/51 , C12N15/88 , C07D295/13 , A61K48/00
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。还提供了从市售的原料制备氨基醇类固醇的方法。氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些氨基醇类脂质化合物的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的类脂和多核苷酸的复合物，胶束，脂质体或颗粒。本发明的类脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

5. 发明申请

US20120251560A1 CONJUGATED LIPOMERS AND USES THEREOF 有权
标题翻译：共混脂肪及其用途
公开(公告)号：US20120251560A1
公开(公告)日：2012-10-04
申请号：US13428695
申请日：2012-03-23
申请人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
发明人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC分类号： A61K31/133 , C07D257/02 , C07D267/00 , A61K8/41 , A61K38/02 , A61K39/00 , A61P37/04 , A61P35/00 , C07C215/14 , A61K31/7088
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/59 , A61K47/6907 , A61K47/6911 , A61K47/6921 , C07D257/02 , C07D273/00 , C07D273/08 , C07D295/084 , C08G73/10 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32
摘要： The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
摘要翻译：本发明提供含有一个或多个式（ⅲ）的基团的本发明的共轭聚乙烯亚胺（PEI）聚合物和共轭氮杂 - 大环化合物（统称为共轭脂族或脂肪族），其中R 3和R 4如本文所定义。还提供了包含本发明的共轭脂族物的组合物，以及制备和使用方法。

6. 发明授权

US09193827B2 Poly(beta-amino alcohols), their preparation, and uses thereof 有权
标题翻译：聚（β-氨基醇），它们的制备及其用途
公开(公告)号：US09193827B2
公开(公告)日：2015-11-24
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , A61L31/10 , C09D5/16 , C08G59/22 , C08G59/30 , C08G59/50 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

7. 发明授权

US08562966B2 End-modified poly(beta-amino esters) and uses thereof 有权
标题翻译：末端改性的聚（β-氨基酯）及其用途
公开(公告)号：US08562966B2
公开(公告)日：2013-10-22
申请号：US13312224
申请日：2011-12-06
申请人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
发明人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K31/765 , A61K9/14 , A61K38/00 , A61K48/00 , A61K47/00 , C08G63/91
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译：聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。末端修饰的聚合物特别可用于递送核酸如DNA或RNA。本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。

8. 发明申请

US20120149630A1 END-MODIFIED POLY(BETA-AMINO ESTERS) AND USES THEREOF 有权
标题翻译：末端改性多糖（BETA-AMINO ESTERS）及其用途
公开(公告)号：US20120149630A1
公开(公告)日：2012-06-14
申请号：US13312224
申请日：2011-12-06
申请人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
发明人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K38/02 , A61K31/7088 , C08G63/91 , A61K47/34 , B82Y5/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译：聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。末端修饰的聚合物特别可用于递送核酸如DNA或RNA。本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。

9. 发明申请

US20120009222A1 MODULATION OF THE IMMUNE RESPONSE 审中-公开
标题翻译：调节免疫应答
公开(公告)号：US20120009222A1
公开(公告)日：2012-01-12
申请号：US13126260
申请日：2009-10-27
申请人： David-Huy Nhu Nguyen , Daniel Griffith Anderson , Robert S. Langer , Kerry Peter Mahon
发明人： David-Huy Nhu Nguyen , Daniel Griffith Anderson , Robert S. Langer , Kerry Peter Mahon
IPC分类号： A61K31/7088 , A61P37/02 , B82Y5/00
CPC分类号： A61K39/39 , A61K31/132 , A61K47/6911 , A61K47/6921 , A61K2039/55561 , A61K2039/55572 , C12N2760/16011
摘要： The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
摘要翻译：本发明提供可用于调节受试者的免疫应答的类脂质。通过将丙烯酸丁酯偶联加成丙烯酰胺制备脂质体。脂类与免疫刺激多核苷酸形成复合物或颗粒，然后将其施用于受试者。已经发现这些组合物刺激细胞因子的产生并增加体液和细胞中介免疫应答。本发明还提供其药物组合物及其使用方法。

10. 发明申请

US20110280912A1 DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS 审中-公开
标题翻译：可降解聚合物纳米结构材料
公开(公告)号：US20110280912A1
公开(公告)日：2011-11-17
申请号：US12969558
申请日：2010-12-15
申请人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
发明人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
IPC分类号： A61K9/00 , C08L47/00 , A61K35/12 , C08L67/02 , C08L67/00 , B82Y5/00
CPC分类号： C08J5/005 , B82Y30/00 , C08J2379/00
摘要： This invention relates generally to composites comprising a plurality of nanostructures, and methods of making the same. In some embodiments, the composites further comprise a polymer. In some embodiments, the composites may have desirable properties such as, for example, biodegradability, biocompatibility, and/or high tensile strength. In one embodiment, the plurality of nanostructures comprises carbon nanotubes, and the polymer comprises a poly(beta-amino ester). Various methods are provided for preparing the composites. For example, the polymer and the plurality of nanostructures may, in some embodiments, be combined in a layer-by-layer process to form the composite. High throughput methods for preparing composites having different compositions also are provided for screening composites for desirable properties.
摘要翻译：本发明一般涉及包含多个纳米结构的复合材料及其制备方法。在一些实施方案中，复合材料还包含聚合物。在一些实施方案中，复合材料可具有期望的性质，例如生物降解性，生物相容性和/或高拉伸强度。在一个实施方案中，多个纳米结构包含碳纳米管，并且聚合物包含聚（β-氨基酯）。提供了各种制备复合材料的方法。例如，在一些实施方案中，聚合物和多个纳米结构可以以逐层方法组合以形成复合材料。还提供了用于制备具有不同组成的复合材料的高通量方法用于筛选复合材料以获得所需性能。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式