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1. 发明授权

US5531779A Stent-type defibrillation electrode structures 失效
标题翻译：支架型除颤电极结构
公开(公告)号：US5531779A
公开(公告)日：1996-07-02
申请号：US377494
申请日：1995-01-24
申请人： Roger W. Dahl , Robert W. Wickham, deceased , David K. Swanson , David Lipson
发明人： Roger W. Dahl , Robert W. Wickham, deceased , David K. Swanson , David Lipson
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/3956 , A61N2001/0585
摘要： Implantable electrode structures for use in apparatus for applying electrical therapy to a patient's heart in the treatment of arrhythmias such as tachycardias and fibrillations of the heart are herein disclosed. The electrode structures are made in the form of expandable (or self-expanding) intravascular stents for insertion through the patient's vascular system to locations in or adjacent the heart. The electrode structures can be inserted into the great veins by insertion techniques used for intravascular stent applications and provide increased electrode surfaces for discharge of electrical energy through the heart in conjunction with other strategically placed electrodes. The wire filament of the stents may be evenly spaced to form a circumferential array or may be non-uniformly spaced to form an elliptical array.
摘要翻译：本文公开了用于在治疗心律不齐（例如心动过速和心脏颤动）的患者心脏中施加电疗法的装置中的植入式电极结构。电极结构以可扩张（或自扩张）血管内支架的形式制成，用于通过患者的血管系统插入到心脏中或邻近心脏的位置。电极结构可以通过用于血管内支架应用的插入技术插入大静脉，并提供增加的电极表面，用于与其他策略放置的电极结合，通过心脏排出电能。支架的丝线可以均匀间隔开以形成圆周阵列，或者可以不均匀地间隔开以形成椭圆形阵列。

2. 发明授权

US5554178A Metalized implantable cardiac electrode 失效
标题翻译：金属化植入式心脏电极
公开(公告)号：US5554178A
公开(公告)日：1996-09-10
申请号：US427942
申请日：1995-04-26
申请人： Roger W. Dahl , David Lipson
发明人： Roger W. Dahl , David Lipson
IPC分类号： A61N1/05 , A61N1/362 , A61N1/378
CPC分类号： A61N1/05
摘要： An implantable cardiac electrode includes a flexible polymeric substrate, a metallized surface layer of the polymeric substrate forming one or more electrically conductive regions on the surface of the polymeric substrate, and one or more insulated conductors connecting the electrically conductive regions to leads, the leads being connected to a cardiac monitoring and pulse generating system. In one embodiment, the electrically conductive region forms a band on the outer surface of a polymeric tube and is electrically connected to a conductor embedded in the tube. In another embodiment, the electrically conductive region forms a desired configuration on a planar surface of the polymeric substrate, such as a concentric ring or spiral patch configuration. In these and other embodiments, the metallized surface layer includes a surface layer of the polymeric substrate that is impregnated with a metal such that a conductive region is formed in the surface of the otherwise insulative polymeric substrate.
摘要翻译：可植入心脏电极包括柔性聚合物基底，在聚合物基底的表面上形成一个或多个导电区域的聚合物基底的金属化表面层以及将导电区域连接到引线的一个或多个绝缘导体，引线是连接到心脏监测和脉冲发生系统。在一个实施例中，导电区域在聚合物管的外表面上形成带，并且电连接到嵌入管中的导体。在另一个实施例中，导电区域在聚合物基底的平坦表面上形成期望的构造，例如同心环或螺旋形贴片构型。在这些和其它实施例中，金属化表面层包括浸渍有金属的聚合物基材的表面层，使得在其它绝缘聚合物基材的表面中形成导电区域。

3. 发明授权

US09020600B2 Magnetic control of eyelid position 有权
标题翻译：眼睑位置的磁力控制
公开(公告)号：US09020600B2
公开(公告)日：2015-04-28
申请号：US13995024
申请日：2011-12-16
申请人： David Lipson , Gary J. Lelli, Jr. , Mark Rosenblatt , Rohini Rao , Nadee Nissanka
发明人： David Lipson , Gary J. Lelli, Jr. , Mark Rosenblatt , Rohini Rao , Nadee Nissanka
IPC分类号： A61N1/00 , A61F9/007 , G02C11/00 , A61N2/00 , A61N2/02 , A61N2/06
CPC分类号： A61F9/00718 , A61N2/004 , A61N2/02 , A61N2/06 , G02C11/00 , G02C2200/02
摘要： Methods, devices, and kits comprising a magnetic system for automation of blinking, or to provide temporary or permanent assistance with opening or closure of the eyelids to treat disorders of the eyelids, including lagophthalmos and ptosis.
摘要翻译：包括用于自动化眨眼的磁性系统的方法，装置和试剂盒，或提供用于打开或闭合眼睑的临时或永久性辅助以治疗眼睑的疾病，包括眼睑和上睑下垂。

4. 发明申请

US20110066146A1 Suction Stabilized Epicardial Ablation Devices 审中-公开
标题翻译：吸入稳定的心外膜消融装置
公开(公告)号：US20110066146A1
公开(公告)日：2011-03-17
申请号：US12881633
申请日：2010-09-14
申请人： Scott E. Jahns , Donald N. Jensen , David Lipson , Jon M. Ocel , Gregory P. Werness
发明人： Scott E. Jahns , Donald N. Jensen , David Lipson , Jon M. Ocel , Gregory P. Werness
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2017/00053 , A61B2017/00084 , A61B2017/00092 , A61B2017/00203 , A61B2017/00243 , A61B2017/00867 , A61B2017/0243 , A61B2017/306 , A61B2018/00011 , A61B2018/00291 , A61B2018/00363 , A61B2018/00577 , A61B2018/00809 , A61B2018/00839 , A61B2018/1425 , A61B2018/143
摘要： A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.
摘要翻译：具有支撑表面的抽吸辅助消融装置，邻近支撑表面设置的抽吸元件，至少一个电极和至少一个吸入管道。该装置还可以包括流体开口，其允许流体冲洗靶组织并有助于消融。还提供了一种使用抽吸消融组织的方法。

5. 发明申请

US20050090816A1 Fluid-assisted medical devices, systems and methods 有权
标题翻译：流体辅助医疗器械，系统和方法
公开(公告)号：US20050090816A1
公开(公告)日：2005-04-28
申请号：US10488801
申请日：2002-09-06
申请人： Michael McClurken , David Lipson , Arnold Oyola , Jonathan Wilson , Christopher Maurer , Robert Luzzi , Roger Greeley
发明人： Michael McClurken , David Lipson , Arnold Oyola , Jonathan Wilson , Christopher Maurer , Robert Luzzi , Roger Greeley
IPC分类号： A61B18/00 , A61B18/08 , A61B18/12 , A61B18/14
CPC分类号： A61B18/148 , A61B17/32 , A61B18/1206 , A61B18/1442 , A61B2018/00011 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/00404 , A61B2018/00589 , A61B2018/00595 , A61B2018/00601 , A61B2018/0063 , A61B2018/00702 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00809 , A61B2018/00875 , A61B2018/126 , A61B2018/1412 , A61B2018/1417 , A61B2018/1422 , A61B2018/1455 , A61B2018/1861 , A61B2218/002
摘要： An electrosurgical device is provided which comprises a distal portion having a bipolar electrode configuration and at least one fluid outlet opening. The device further includes a first electrode tip spaced from a second electrode tip with the first electrode tip to serve as a first pole of the bipolar electrode configuration and the second electrode tip to serve as a second pole of the bipolar electrode configuration. The first and second electrode tips are configured to slide over a tissue surface in the presence of a fluid provided from the fluid outlet opening and an electrical current provided from the electrode tips.
摘要翻译：提供了一种电外科装置，其包括具有双极电极构造的远端部分和至少一个流体出口开口。该器件还包括与第二电极尖端间隔开的第一电极尖端与第一电极尖端以用作双极电极构造的第一极点，而第二电极尖端用作双极电极构造的第二极点。第一和第二电极尖端构造成在存在从流体出口开口提供的流体和从电极尖端提供的电流的情况下在组织表面上滑动。

6. 发明授权

US5837900A System and method for detecting metal ion oxidation in pacing lead 失效
标题翻译：起搏铅金属离子氧化检测系统及方法
公开(公告)号：US5837900A
公开(公告)日：1998-11-17
申请号：US670793
申请日：1996-06-21
申请人： David Lipson
发明人： David Lipson
IPC分类号： G01H13/00 , G01N29/12 , G01H11/06 , A61N1/00 , A61N1/362
CPC分类号： G01N29/12 , G01H13/00 , G01N2291/014 , G01N2291/02836 , G01N2291/2626
摘要： There is provided a system and method for determining the existence of metal ion oxidation degradation in an implanted pacing lead. A micro-vibration driver, preferably operating at a sonic frequency matched to an ultrasound detector, is used to vibrate the proximal end of a stylet that has been inserted into the lumen of a bipolar lead. The shaking of the stylet causes flexural waves to be propagated along the stylet, which in turn flex the lead inner conductor and the insulation between the inner and outer conductor. If metal ion oxidation is present in the insulation, the shaking causes generation of a noise signal which is detectable across the conductors along with the electrogram. The presence of such a noise signal is correlated with the output of the driver, i.e., with the vibration of the lead, to indicate when MIO degradation is present. An ultrasound imaging detector can be used to determine the location of the MIO degradation along the length of the lead.
摘要翻译：提供了一种用于确定植入起搏引线中金属离子氧化降解的存在的系统和方法。使用优选以与超声波检测器相匹配的声频操作的微振动驱动器来振动已经插入双极引线的内腔中的探针的近端。探针的振动导致弯曲波沿探针传播，从而使引线内部导体和内部和外部导体之间的绝缘弯曲。如果绝缘体中存在金属离子氧化，则振动导致产生可与电描记图一起在导体上检测的噪声信号。这种噪声信号的存在与驱动器的输出相关，即与引线的振动相关联，以指示何时存在MIO降级。可以使用超声成像检测器来确定沿导线长度的MIO退化的位置。

7. 发明申请

US20130274541A1 MAGNETIC CONTROL OF EYELID POSITION 有权
标题翻译：眼睛位置的磁控制
公开(公告)号：US20130274541A1
公开(公告)日：2013-10-17
申请号：US13995024
申请日：2011-12-16
申请人： David Lipson , Gary J. Lelli, JR. , Mark Rosenblatt , Rohini Rao , Nadee Nissanka
发明人： David Lipson , Gary J. Lelli, JR. , Mark Rosenblatt , Rohini Rao , Nadee Nissanka
IPC分类号： A61F9/007 , A61N2/02 , A61N2/06 , A61N2/00
CPC分类号： A61F9/00718 , A61N2/004 , A61N2/02 , A61N2/06 , G02C11/00 , G02C2200/02
摘要： Methods, devices, and kits comprising a magnetic system for automation of blinking, or to provide temporary or permanent assistance with opening or closure of the eyelids to treat disorders of the eyelids, including lagophthalmos and ptosis.
摘要翻译：包括用于自动化眨眼的磁性系统的方法，装置和试剂盒，或提供用于打开或闭合眼睑的临时或永久性辅助以治疗眼睑的疾病，包括眼睑和上睑下垂。

8. 发明申请

US20120238520A1 Novel Medical Use 审中-公开
标题翻译：新型医疗用途
公开(公告)号：US20120238520A1
公开(公告)日：2012-09-20
申请号：US13512901
申请日：2010-12-03
申请人： David Lipson
发明人： David Lipson
IPC分类号： A61K31/7076 , A61P9/10 , A61P11/00 , C07H19/16 , A61P29/00
CPC分类号： A61K31/7076
摘要： The present invention relates to a compound which is (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of inflammatory and non-inflammatory diseases abd conditions associated with alveolar filling.
摘要翻译：本发明涉及（2R，3R，4S，5R）-2-（6-氨基-2 - {[（1S）-2-羟基-1-（苯基甲基）乙基]氨基} 嘌呤-9-基）-5-（2-乙基-2H-四唑-5-基）四氢-3,4-呋喃二醇或其药学上可接受的盐，用于治疗或预防炎性和非炎性疾病abd 与肺泡填充相关的病症。

9. 发明授权

US07818039B2 Suction stabilized epicardial ablation devices 有权
标题翻译：吸入稳定的心外膜消融装置
公开(公告)号：US07818039B2
公开(公告)日：2010-10-19
申请号：US11182464
申请日：2005-07-15
申请人： Scott E. Jahns , Donald N. Jensen , David Lipson , Jon M. Ocel , Gregory P. Werness
发明人： Scott E. Jahns , Donald N. Jensen , David Lipson , Jon M. Ocel , Gregory P. Werness
IPC分类号： A61B5/0402 , A61B18/14 , A61N1/05
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2017/00053 , A61B2017/00084 , A61B2017/00092 , A61B2017/00203 , A61B2017/00243 , A61B2017/00867 , A61B2017/0243 , A61B2017/306 , A61B2018/00011 , A61B2018/00291 , A61B2018/00363 , A61B2018/00577 , A61B2018/00809 , A61B2018/00839 , A61B2018/1425 , A61B2018/143
摘要： A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.
摘要翻译：具有支撑表面的抽吸辅助消融装置，邻近支撑表面设置的抽吸元件，至少一个电极和至少一个吸入管道。该装置还可以包括流体开口，其允许流体冲洗靶组织并有助于消融。还提供了一种使用抽吸消融组织的方法。

10. 发明申请

US20050033278A1 Fluid assisted medical devices, fluid delivery systems and controllers for such devices, and methods 审中-公开
标题翻译：流体辅助医疗设备，流体输送系统和用于这种装置的控制器以及方法
公开(公告)号：US20050033278A1
公开(公告)日：2005-02-10
申请号：US10488416
申请日：2002-09-05
申请人： Michael McClurken , David Lipson , Arnold Oyola , Robert Luzzi
发明人： Michael McClurken , David Lipson , Arnold Oyola , Robert Luzzi
IPC分类号： A61B18/00 , A61B18/08 , A61B18/12 , A61B18/14
CPC分类号： A61B18/1445 , A61B17/32 , A61B18/1206 , A61B18/14 , A61B18/1442 , A61B2018/00011 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/00404 , A61B2018/00589 , A61B2018/00595 , A61B2018/00601 , A61B2018/0063 , A61B2018/00702 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00809 , A61B2018/00875 , A61B2018/126 , A61B2018/1412 , A61B2018/1417 , A61B2018/1422 , A61B2018/1455 , A61B2018/1861 , A61B2218/002
摘要： Medical devices, methods and systems for treating tissue are provided. An exemplary system comprises a fluid from a fluid from a fluid source at a fluid flow rate, a surgical device which provides power and the fluid to the tissue and a control mechanism which changes a fluid flow rate provided from the surgical device and changes a power level provided from the surgical device. The fluid flow rate changes between at least two-zero flow rates and the power level changes between at least two non-zero levels. An exemplary method comprises providing a fluid from a fluid source at a fluid flow rate, providing a surgical device which provides power and the fluid to the tissue, and changing the fluid flow rate of fluid provided from the surgical device with a change in power level provided from the surgical device.
摘要翻译：提供了用于治疗组织的医疗装置，方法和系统。示例性系统包括来自流体源的流体以流体流速的流体，向组织提供动力和流体的外科装置以及改变从外科装置提供的流体流速并改变功率的控制机构从手术器械提供的水平。流体流速在至少两个零流量之间变化，功率水平在至少两个非零水平之间变化。一种示例性方法包括以流体流速从流体源提供流体，提供将功能和流体提供给组织的手术装置，以及改变从手术装置提供的流体的流体流速，功率水平的变化由外科装置提供。

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