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1. 发明授权

US5951458A Local application of oxidizing agents to prevent restenosis 失效
标题翻译：局部应用氧化剂预防再狭窄
公开(公告)号：US5951458A
公开(公告)日：1999-09-14
申请号：US905296
申请日：1997-08-01
申请人： Roger N. Hastings , Lixiao Wang , Dachuan Yang , Mark T. Ungs , Michael J. Urick
发明人： Roger N. Hastings , Lixiao Wang , Dachuan Yang , Mark T. Ungs , Michael J. Urick
IPC分类号： A61F2/958 , A61M25/01 , A61M29/02 , A61M36/04 , A61N5/10 , A61M5/00
CPC分类号： A61M25/1002 , A61M25/0127 , A61N5/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N2005/1003
摘要： A method for inhibiting restenosis including local application of an oxidizing agent to blood vessel walls. Preferred oxidizing agents include peroxides, most preferably hydrogen peroxide. Oxidizing agents can be delivered utilizing drug delivery balloon catheters. Preferred delivery catheters include an inflatable balloon having a perfusion lumen therethrough to allow for longer application periods. Oxidizing agents can be delivered either alone or in conjunction with radiation or stent delivery. One method includes local delivery of 0.1% hydrogen peroxide to a dilated stenosis wall for a period of 10 minutes at a rate of 0.5 cc per minute.
摘要翻译：一种抑制再狭窄的方法，包括将氧化剂局部施用于血管壁。优选的氧化剂包括过氧化物，最优选过氧化氢。可以使用药物递送球囊导管递送氧化剂。优选的输送导管包括具有穿过其中的灌注腔的可充气气囊，以允许更长的施用周期。氧化剂可单独或与辐射或支架递送联合递送。一种方法包括以0.5cc /分钟的速率将0.1％过氧化氢局部递送至扩张狭窄壁10分钟。

2. 发明授权

US6117065A Perfusion balloon catheter with radioactive source 失效
标题翻译：灌注气囊导管放射源
公开(公告)号：US6117065A
公开(公告)日：2000-09-12
申请号：US103595
申请日：1998-06-24
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61M36/04 , A61N5/10 , A61M29/00
CPC分类号： A61N5/1002 , A61M2025/0063 , A61N2005/1003 , A61N2005/1004
摘要： A device for irradiating human vessel interior walls including a perfusion balloon catheter having a radioactive perfusion tube affixed therein. Preferably, the balloon is helical, having adjacent helical strand windings closely spaced in contact upon inflation to minimize trapped blood and reduce attenuation. The perfusion tube can be made radioactive by inclusion of a helical, radioactive metal coil in the perfusion tube wall. In use, the catheter can be advanced over a guide wire to a stenosis, inflated to dilate the site, with beta radiation from the coil passing through the device to the vessel walls, relatively unhindered by blood.
摘要翻译：一种用于照射人体血管内壁的装置，包括具有固定在其中的放射性灌注管的灌注球囊导管。优选地，气囊是螺旋形的，其具有在充气时紧密间隔开的相邻螺旋线圈绕组以最小化被捕获的血液并减少衰减。灌注管可以通过在灌注管壁中包含螺旋放射性金属线圈而被制成放射性。在使用中，导管可以在导丝上前进到狭窄，充气以扩张部位，来自线圈的β辐射通过装置到血管壁，相对不受血液阻碍。

3. 发明授权

US5855546A Perfusion balloon and radioactive wire delivery system 失效
公开(公告)号：US5855546A
公开(公告)日：1999-01-05
申请号：US868482
申请日：1997-06-03
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61F2/958 , A61M25/01 , A61M29/02 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61M25/0127 , A61M25/1002 , A61N5/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N2005/1003
摘要： A catheter capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters are capable of simultaneous irradiation, angioplasty, and in some devices, drug infusion. Preferred catheters include a helical perfusion balloon having strand windings spaced apart when inflated and defining a perfusion lumen within. A tubular sheath over the helical strands and distal shaft region is used in some embodiments and defines an outer wall for the perfusion lumen. A spiral, inter-strand space is defined between the sheath outer wall and the blood vessel inner wall, providing a confined volume for controlled delivery of drugs to the vessel wall in conjunction with irradiation. A device having a radiation wire, distally closed-end tube is provided. A device having a radiation wire open ended tube terminating proximally of the perfusion lumen is also provided.

4. 发明授权

US6110097A Perfusion balloon catheter with radioactive source 失效
公开(公告)号：US6110097A
公开(公告)日：2000-08-29
申请号：US812757
申请日：1997-03-06
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61M2025/0063 , A61N2005/1003 , A61N2005/1004
摘要： A device for irradiating human vessel interior walls including a perfusion balloon catheter having a radioactive perfusion tube affixed therein. Preferably, the balloon is helical, having adjacent helical strand windings closely spaced in contact upon inflation to minimize trapped blood and reduce attenuation. The perfusion tube can be made radioactive by inclusion of a helical, radioactive metal coil in the perfusion tube wall. In use, the catheter can be advanced over a guide wire to a stenosis, inflated to dilate the site, with beta radiation from the coil passing through the device to the vessel walls, relatively unhindered by blood.

5. 发明授权

US6099454A Perfusion balloon and radioactive wire delivery system 失效
标题翻译：灌注气球和放射线输送系统
公开(公告)号：US6099454A
公开(公告)日：2000-08-08
申请号：US812248
申请日：1997-03-06
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61F2/958 , A61M25/01 , A61M29/02 , A61N5/10 , A61N5/00
CPC分类号： A61M25/0127 , A61M25/1002 , A61N5/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N2005/1003
摘要： A catheter capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters are capable of simultaneous irradiation and angioplasty. Preferred catheters include a helical perfusion balloon having closely spaced or contacting adjacent windings when inflated. A helical balloon with strand windings having little space therebetween decreases the amount of blood between the balloon exterior surface and vessel walls. A removable, sheathed, elongate radiation source is used with some embodiments. A fixed, flexible sheath partitioning the catheter lumen into sterile and non-sterile portions is included in another embodiment. Internal rather than external perfusion and use of gas to inflate the balloon decrease the absorption of beta radiation by blood, and liquid inflation fluid, respectively.
摘要翻译：导管能够照射血管壁以抑制血管成形术后的再狭窄。导管能同时照射和血管成形术。优选的导管包括在充气时具有紧密间隔或接触相邻绕组的螺旋灌注球囊。具有很小空间的股线绕组的螺旋形气球减少球囊外表面和血管壁之间的血液量。一些实施例使用可移除的，护套的细长辐射源。在另一实施例中包括将导管内腔分成无菌和非无菌部分的固定的柔性护套。内部而不是外部灌注和使用气体来充气气球分别降低了血液和液体膨胀液对β辐射的吸收。

6. 发明授权

US06676590B1 Catheter system having tubular radiation source 失效
标题翻译：具有管状辐射源的导管系统
公开(公告)号：US06676590B1
公开(公告)日：2004-01-13
申请号：US08984490
申请日：1997-12-08
申请人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
发明人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
IPC分类号： A61N500
CPC分类号： A61N5/1002 , A61M2025/0063 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source for inhibiting restenosis including a radiation delivery tube having a radioactive distal region, the tube being adapted to slide over a guide wire within a radiation delivery catheter. One tube has radioactive material incorporated into the tube wall material. Another tube has radioactive material secured to the tube surface. One radiation delivery balloon catheter includes a common inflation and radiation delivery lumen, the lumen being sealed distally and having a radiation source guide wire within the lumen. The lumen is sealed from contact with bodily fluids and is filled with inflation fluid during use. In use, the catheter balloon is advanced to a site to be treated, the balloon inflated, and the radioactive tube advanced over the radiation source guide wire within the lumen.
摘要翻译：一种用于抑制再狭窄的辐射源，其包括具有放射性远侧区域的辐射递送管，所述管适于在辐射递送导管内的导丝上滑动。一管将放射性物质并入管壁材料中。另一管具有固定到管表面的放射性材料。一个辐射递送球囊导管包括公共的充气和辐射递送腔，该内腔被向远侧密封并且在内腔内具有辐射源导丝。管腔与体液接触密封，并在使用过程中充满充气液。在使用中，导管球囊前进到要治疗的部位，气囊膨胀，并且放射管在腔内的辐射源导丝上前进。

7. 发明授权

US06398708B1 Perfusion balloon and radioactive wire delivery system 有权
标题翻译：灌注气球和放射线输送系统
公开(公告)号：US06398708B1
公开(公告)日：2002-06-04
申请号：US09181111
申请日：1998-10-28
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61N500
CPC分类号： A61M25/0127 , A61M25/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N5/1002 , A61N2005/1003
摘要： A catheter capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters are capable of simultaneous irradiation, angioplasty, and in some devices, drug infusion. Preferred catheters include a helical perfusion balloon having strand windings spaced apart when inflated and defining a perfusion lumen within. A tubular sheath over the helical strands and distal shaft region is used in some embodiments and defines an outer wall for the perfusion lumen. A spiral, inter-strand space is defined between the sheath outer wall and the blood vessel inner wall, providing a confined volume for controlled delivery of drugs to the vessel wall in conjunction with irradiation. A device having a radiation wire, distally closed-end tube is provided. A device having a radiation wire open ended tube terminating proximally of the perfusion lumen is also provided.
摘要翻译：导管能够照射血管壁以抑制血管成形术后的再狭窄。导管能够同时照射，血管成形术，并在某些装置中进行药物输注。优选的导管包括螺旋灌注球囊，其具有在充气时间隔开并且在其内限定灌注内腔的股线绕组。在一些实施例中使用螺旋股线和远端轴区域上的管状护套，并且限定了用于灌注腔的外壁。在护套外壁和血管内壁之间限定了螺旋形的股间空间，提供了限制的体积，用于将药物与照射相结合地控制输送到血管壁。提供了一种具有辐射线，远端封闭端管的装置。还提供了具有在灌注腔的近侧终止的放射线开口管的装置。

8. 发明授权

US6059713A Catheter system having tubular radiation source with movable guide wire 失效
标题翻译：导管系统具有带可动导丝的管状辐射源
公开(公告)号：US6059713A
公开(公告)日：2000-05-09
申请号：US35705
申请日：1998-03-05
申请人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
发明人： Michael J. Urick , Timothy G. J. Ehr , Roger N. Hastings
IPC分类号： A61F2/958 , A61M29/02 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61M2025/0063 , A61M2025/0656 , A61M2025/1061 , A61M25/0138 , A61M25/1002 , A61M25/104 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source for inhibiting restenosis including a radiation delivery tube having a radioactive distal region, the tube being adapted to slide over a core wire within a radiation delivery catheter. The core wire is preferably in a slidable relation with the radiation delivery catheter. By withdrawing the core wire to a proximal position, the flexibility of a distal region of the radiation delivery catheter may be increased, thereby allowing the radiation delivery catheter to navigate more tortuous paths and reach more distal sites. Before the radiation delivery tube is advanced into the catheter distal region, the core wire is preferably slid distally to a distal position. With the core wire in the distal position, the core wire may provide a structure that can be used to rapidly advance the radiation source to the lesion site. The core wire may also help constrain lateral movement of the radiation delivery tube and help center the radiation delivery tube within the vessel to provide a more even radiation exposure to the vessel walls.
摘要翻译：一种用于抑制再狭窄的辐射源，包括具有放射性远侧区域的辐射递送管，所述管适于在辐射递送导管内的芯线上滑动。芯线优选地与辐射递送导管可滑动关系。通过将芯线抽出到近端位置，可以增加放射线输送导管的远端区域的柔性，从而允许放射线输送导管更多的曲折路径导航并到达更远侧的位置。在辐射输送管进入导管远端区域之前，芯线优选地向远侧滑动到远端位置。在芯线处于远端位置时，芯线可以提供可用于将辐射源快速推进到病变部位的结构。芯线还可以有助于限制辐射输送管的横向运动，并帮助辐射输送管在容器内居中以提供更均匀的辐射暴露于血管壁。

9. 发明授权

US5865720A Expandable and retrievable radiation delivery system 失效
标题翻译：可扩展和可回收的辐射传播系统
公开(公告)号：US5865720A
公开(公告)日：1999-02-02
申请号：US812022
申请日：1997-03-06
申请人： Roger N. Hastings , Michael J. Urick
发明人： Roger N. Hastings , Michael J. Urick
IPC分类号： A61M25/00 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61N2005/1004
摘要： A device and method for irradiating human body vessel interior walls. One device includes a beta radiation emitting segmented metal tube disposed at the distal end of an elongate shaft. Another device includes a radioactive elastic sleeve mounted on a shaft. The device can be used to inhibit restenosis following angioplasty in coronary arteries. In use, the device can be advanced distally over the balloon portion of a positioned and deflated angioplasty balloon catheter, whereupon the balloon is inflated, pressing the radiation device into close contact with vessel walls. After a desired exposure period, the balloon is deflated, and the device, biased to contract, contracts with the balloon, allowing for ease of withdrawal from the patient.
摘要翻译：用于照射人体血管内壁的装置和方法。一个装置包括设置在细长轴远端的β辐射发射分段金属管。另一装置包括安装在轴上的放射性弹性套筒。该装置可用于在冠状动脉血管成形术后抑制再狭窄。在使用中，装置可以在定位和放气的血管成形术球囊导管的气囊部分上向远侧推进，于是球囊膨胀，将辐射装置压迫与血管壁紧密接触。在期望的暴露期后，气囊被放气，并且被偏压收缩的装置与气囊收缩，从而容易地从患者中撤出。

10. 发明授权

US06398709B1 Elongated member for intravascular delivery of radiation 有权
标题翻译：血管内传递辐射的细长成员
公开(公告)号：US06398709B1
公开(公告)日：2002-06-04
申请号：US09420677
申请日：1999-10-19
申请人： Timothy G.J. Ehr , Sherri Henkemeyer , Michael J. Urick , Jeffrey H. Vogel
发明人： Timothy G.J. Ehr , Sherri Henkemeyer , Michael J. Urick , Jeffrey H. Vogel
IPC分类号： A61N500
CPC分类号： A61N5/1002
摘要： A radioactive source for use in intravascular treatment includes an elongated wire having a first diameter and an integral distal end having a second diameter. The second diameter is less than the first diameter. A plurality of spaced apart toroidal elements are disposed on the distal end of the wire. The toroidal elements include radioactive material.
摘要翻译：用于血管内治疗的放射源包括具有第一直径和具有第二直径的整体远端的细长线。第二直径小于第一直径。多个间隔开的环形元件设置在线的远端上。环形元件包括放射性材料。

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