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1. 发明授权

US4507296A Tetrazoles, pharmaceutical use and compositions 失效
标题翻译：四唑，药用和组合物
公开(公告)号：US4507296A
公开(公告)日：1985-03-26
申请号：US569152
申请日：1984-01-09
申请人： Roger Hayes , David E. Bays , John W. M. Mackinnon , Linda Carey
发明人： Roger Hayes , David E. Bays , John W. M. Mackinnon , Linda Carey
IPC分类号： C07C279/28 , C07D239/46 , C07D249/14 , C07D257/06 , C07D295/096 , C07D471/04 , A61K31/41 , C07D257/04
CPC分类号： C07D239/47 , C07C279/28 , C07D249/14 , C07D257/06 , C07D295/096 , C07D471/04
摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts or hydrates thereof, in which the substituents are defined later in the specification.The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明涉及通式（I）的化合物及其生理上可接受的盐或水合物，其中取代基在本说明书的后面定义。该化合物显示出作为选择性组胺H2拮抗剂的药理学活性。

2. 发明授权

US4518598A 1,2,4-Triazole-3-amines, their pharmaceutical compositions and method of use 失效
标题翻译： 1,2,4-三唑-3-胺，其药物组合物和使用方法
公开(公告)号：US4518598A
公开(公告)日：1985-05-21
申请号：US569151
申请日：1984-01-09
申请人： Roger Hayes , David E. Bays , John W. M. Mackinnon , Linda Carey , Philip Blatcher
发明人： Roger Hayes , David E. Bays , John W. M. Mackinnon , Linda Carey , Philip Blatcher
IPC分类号： C07C279/28 , C07D239/46 , C07D249/14 , C07D257/06 , C07D295/096 , C07D471/04 , A61K31/41
CPC分类号： C07D239/47 , C07C279/28 , C07D249/14 , C07D257/06 , C07D295/096 , C07D471/04
摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, and hydrates thereof. The substituents are defined in the specification.The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明涉及通式（I）的化合物及其生理学上可接受的盐及其水合物。取代基在说明书中定义。该化合物显示出作为选择性组胺H2拮抗剂的药理学活性。

3. 发明授权

US4670448A Triazole amine compounds, their pharmaceutical compositions and method of use 失效
标题翻译：三唑胺化合物，其药物组合物和使用方法
公开(公告)号：US4670448A
公开(公告)日：1987-06-02
申请号：US465616
申请日：1983-02-10
申请人： John W. Clitherow , John Bradshaw , John W. M. Mackinnon , Duncan B. Judd , David E. Bays , Roger Hayes , Andrew Pearce
发明人： John W. Clitherow , John Bradshaw , John W. M. Mackinnon , Duncan B. Judd , David E. Bays , Roger Hayes , Andrew Pearce
IPC分类号： C07D249/00 , A61K31/41 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P1/04 , A61P29/00 , A61P43/00 , C07D209/48 , C07D213/86 , C07D249/08 , C07D249/10 , C07D249/14 , C07D333/20 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号： C07D209/48 , C07D249/10 , C07D249/14 , C07D333/20 , C07D333/38
摘要： The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which the substituents are defined in the detailed description.The compounds show pharmaceutical activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明提供了通式（I）的化合物及其生理学上可接受的盐，水合物和生物前体，其中取代基在详细描述中定义。该化合物显示药物活性作为选择性组胺H2拮抗剂。

4. 发明授权

US4571394A Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：US4571394A
公开(公告)日：1986-02-18
申请号：US401402
申请日：1982-07-23
申请人： Roger Hayes , David E. Bays , John W. M. MacKinnon
发明人： Roger Hayes , David E. Bays , John W. M. MacKinnon
IPC分类号： C07C279/28 , C07D239/46 , C07D249/14 , C07D257/06 , C07D295/096 , C07D401/06 , C07D471/04 , A61K31/41
CPC分类号： C07D239/47 , C07C279/28 , C07D249/14 , C07D257/06 , C07D295/096 , C07D401/06 , C07D471/04
摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichQ represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4- positions:Z represents one of the groups ##STR2## where X represents NCN, NSO.sub.2 Methyl, NSO.sub.2 Phenyl or CHNO.sub.2. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明涉及通式（I）的化合物及其生理学上可接受的盐，水合物和生物前体，其中Q表示苯环，其中与分子的其余部分结合通过1位的键 - 和3-或1-和4-位：Z代表组IMA IMA中的一个，其中X表示NCN，NSO 2甲基，NSO 2苯基或CHNO 2。该化合物显示出作为选择性组胺H2拮抗剂的药理学活性。

5. 发明授权

US4410523A Heterocyclic derivatives 失效
公开(公告)号：US4410523A
公开(公告)日：1983-10-18
申请号：US199522
申请日：1980-10-22
申请人： William D. Ollis , Barry J. Price , Linda Carey , Roger Hayes , John W. Clitherow , John Bradshaw , John W. M. Mackinnon
发明人： William D. Ollis , Barry J. Price , Linda Carey , Roger Hayes , John W. Clitherow , John Bradshaw , John W. M. Mackinnon
IPC分类号： C07D249/14 , A61K31/395 , C07D249/10
CPC分类号： C07D249/14 , Y10S514/927
摘要： The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, C.sub.1-10 alkyl, cycloalkyl, alkenyl, aralkyl, trifluoroalkyl, heteroaralkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkyamino or cycloalkyl, or R.sub.1 and R.sub.2 may together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups, or a hydroxy group and/or may contain another heteroatom selected from oxygen and sulphur;Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms and is attached to the cyclohexadiene ring at either the 4- or 5- position;X represents --CH.sub.2 or --O--;m represents 2, 3, 4 or 5 and when X is --O-- the chain (CH.sub.2).sub.m may be interrupted by an oxygen atom provided that there are at least two methylene groups between any two heteroatoms in the moiety --X(CH.sub.2).sub.m NH--;R.sub.3 represents hydrogen, alkyl, alkenyl, aralkyl, or C.sub.2-6 alkyl substituted by hydroxy or alkoxy; andR.sub.4 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy or alkoxy or the group NR.sub.5 R.sub.6 whereR.sub.5 represents hydrogen, alkyl, alkyl substituted by hydroxy or C.sub.1-3 alkoxy, alkenyl, aralkyl or heteroaralkyl and R.sub.6 represents any of the groups defined for R.sub.5 or may represent the group COR.sub.7 where R.sub.7 represents hydrogen, alkyl, aryl, aralkyl, alkoxy, heteroaryl or monocyclic heteroaralkyl or R.sub.6 represents the group SO.sub.2 R.sub.8 where R.sub.8 represents alkyl or aryl, or R.sub.6 represents the group ##STR2## where Y is oxygen or sulphur and R.sub.9 represents hydrogen, alkyl, cycloalkyl, aryl or aralkyl,or R.sub.5 and R.sub.6 taken together may represent the group .dbd.CR.sub.10 R.sub.11 where R.sub.10 represents aryl or heteroaryl and R.sub.11 represents hydrogen or alkyl.The compounds show activity as selective histamine H.sub.2 -antagonists.

6. 发明授权

US4777179A Heterocyclic derivatives, processes for the use thereof and pharmaceutical compositions containing them 失效
标题翻译：杂环衍生物，其使用方法和含有它们的药物组合物
公开(公告)号：US4777179A
公开(公告)日：1988-10-11
申请号：US789578
申请日：1985-10-21
申请人： John Bradshaw , Duncan B. Judd , Barry J. Price , John W. Clitherow , John W. M. Mackinnon , Linda Carey , Roger Hayes
发明人： John Bradshaw , Duncan B. Judd , Barry J. Price , John W. Clitherow , John W. M. Mackinnon , Linda Carey , Roger Hayes
IPC分类号： C07D249/14 , C07D333/20 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/42 , A61K31/445 , A61K31/41 , C07D401/10 , C07D403/12 , C07D403/14 , C07D413/10
CPC分类号： C07D333/32 , C07D333/20 , C07D333/28 , C07D333/34 , C07D333/42
摘要： The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms;R.sub.3, which may be in either the 2 or 3-position, represents the ##STR2## where X represents --CH.sub.2 --, --O-- or --S--; n represents zero, 1 or 2;m represents 2, 3 or 4; andR.sub.7 represents hydrogen, alkyl, alkenyl, aralkyl, or C.sub.2-6 alkyl substituted by hydroxy or alkoxy; andR.sub.8 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy or alkoxy, or the group NR.sub.10 R.sub.11 ; with the provisos thatwhere R.sub.2 represents the group R.sub.4 R.sub.5 Nalk then R.sub.3 is in the 2-position;where R.sub.2 represents hydrogen then R.sub.3 is in the 3-position; andwhere R.sub.2 represents halogen or C.sub.1-4 alkyl optionally substituted by hydroxy or C.sub.1-4 alkoxy, and R.sub.3 is in the 2-position, then R.sub.8 cannot represent amino C.sub.1-6 alkyl, C.sub.1-6 alkylamino C.sub.1-6 alkyl, di-C.sub.1-6 alkylamino C.sub.1-6 alkyl or a group NR.sub.10 R.sub.11.The compounds of formula (I) show pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明提供了通式（I）的化合物及其生理上可接受的盐和水合物，其中R 1和R 2中的一个表示氢，卤素或C 1-4烷基，其可任选被羟基或C1- 4烷氧基，另一个表示R4R5NAlk-基团，其中Alk表示1至6个碳原子的直链或支链亚烷基链; 可以在2或3位的R3表示其中X表示-CH 2 - ， - O-或-S-的。 n表示0，1或2; m表示2,3或4; 并且R 7表示氢，烷基，烯基，芳烷基或被羟基或烷氧基取代的C 2-6烷基; 芳基烷氧基烷基，芳氧基烷基，芳烷氧基烷基，氨基烷基，烷基氨基烷基，二烷基氨基烷基，羟基或烷氧基，或基团NR10R11; R10代表氢，烷基，烯基，芳烷基，条件是其中R2表示基团R4R5Nalk，则R3为2-位; 其中R2表示氢，R3表示3-位; 并且其中R 2表示卤素或任选被羟基或C 1-4烷氧基取代的C 1-4烷基，且R 3在2-位，那么R 8不能代表氨基C 1-6烷基，C 1-6烷基氨基C 1-6烷基， C 1-6烷基氨基C 1-6烷基或基团NR 10 R 11。式（I）化合物显示作为选择性组胺H2拮抗剂的药理活性。

7. 发明授权

US4536508A Triazoleamine derivatives having histamine H.sub.2 -antagonist properties 失效
标题翻译：具有组胺H2拮抗剂性质的三唑胺衍生物
公开(公告)号：US4536508A
公开(公告)日：1985-08-20
申请号：US467896
申请日：1983-02-18
申请人： John W. Clitherow , Barry J. Price , John Bradshaw , Michael Martin-Smith , John W. M. Mackinnon , Duncan B. Judd , Roger Hayes
发明人： John W. Clitherow , Barry J. Price , John Bradshaw , Michael Martin-Smith , John W. M. Mackinnon , Duncan B. Judd , Roger Hayes
IPC分类号： C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/55 , A61P43/00 , C07D249/14 , C07D295/096 , C07D307/52 , C07D317/22 , C07D333/36 , C07D401/12 , C07D405/12 , C07D409/12 , C07D521/00 , C07D401/10 , C07D413/10
CPC分类号： C07D295/096 , C07D249/14 , C07D307/52 , C07D317/22 , C07D333/36
摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, which show pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明涉及通式（I）的化合物及其生理学上可接受的盐，水合物和生物前体，其表现出作为选择性组胺H2拮抗剂的药理学活性。

8. 发明授权

US4450168A Pharmaceutical compositions containing compounds having action on histamine receptors 失效
标题翻译：含有对组胺受体有作用的化合物的药物组合物
公开(公告)号：US4450168A
公开(公告)日：1984-05-22
申请号：US513750
申请日：1983-07-14
申请人： David E. Bays , Roger Hayes
发明人： David E. Bays , Roger Hayes
IPC分类号： A61K31/41 , A61P43/00 , C07D249/14 , C07D405/12 , A61K31/44 , C07D403/12
CPC分类号： C07D405/12 , C07D249/14
摘要： Compounds of general formula (I) ##STR1## and physiologically acceptable salts and hydrates thereof in which R.sub.1 and R.sub.2 each represent methyl groups or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexamethylenimino group;R.sub.3 represents hydrogen or methyl;Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms;R.sub.4 represents a hydrogen atom and R.sub.5 represents a C.sub.1-4 alkyl group; or R.sub.4 and R.sub.5 together with the atoms to which they are attached form a tetrahydropyranyl ring; andeither n is zero, X is oxygen, m is 3 or 4, and Q is a benzene ring linked through the 1- and 3- positions;or n is 1, X is sulphur, m is 2, and Q is a furan ring linked through the 2- and 5- positions with optionally a methyl substituent on the carbon atom adjacent to the group R.sub.1 R.sub.2 NCH.sub.2, or Q is a thiophene ring linked through the 2- and 4- positions with the group R.sub.1 R.sub.2 NCH.sub.2 in the 2- position;with the proviso that when Q is other than a benzene ring, R.sub.1 and R.sub.2 are methyl groups, are disclosed as having action as histamine H.sub.2 -antagonists.
摘要翻译：通式（I）化合物（Ⅰ）及其生理上可接受的盐和水合物，其中R 1和R 2各自代表甲基或与它们所连接的氮原子一起形成吡咯烷子基，哌啶子基或六亚甲基亚氨基; R3表示氢或甲基; Alk表示1〜6个碳原子的直链或支链亚烷基链; R4表示氢原子，R5表示C1-4烷基; 或R 4和R 5与它们所连接的原子一起形成四氢吡喃基环; n为0，X为氧，m为3或4，Q为通过1-位和3-位连接的苯环; 或n为1，X为硫，m为2，Q为通过2-和5-位连接的呋喃环，与R1R2NCH2相邻的碳原子上任选具有甲基取代基，或Q为噻吩环连接通过2-位和4-位，其中R1R2NCH2基团在2-位; 条件是当Q不是苯环时，R 1和R 2是甲基，被公开作为组胺H 2拮抗剂的作用。

9. 发明授权

US4485104A 1,2,4-Triazole-3-amines and their pharmaceutical use 失效
标题翻译： 1,2,4-三唑-3-胺及其药物用途
公开(公告)号：US4485104A
公开(公告)日：1984-11-27
申请号：US469231
申请日：1983-02-24
申请人： John W. Clitherow , Barry J. Price , Roger Hayes , David E. Bays
发明人： John W. Clitherow , Barry J. Price , Roger Hayes , David E. Bays
IPC分类号： C07D209/48 , C07D249/14 , C07D295/096 , C07D401/04 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/41 , C07D403/12 , C07D403/14
CPC分类号： C07D209/48 , C07D249/14 , C07D295/096 , C07D401/04 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H.sub.2 -antagonists. The substituents in the compounds of formula (I) are defined in the main body of the disclosure.
摘要翻译：已经发现通式（I）的化合物（I）及其生理上可接受的盐，水合物和生物前体已显示出作为选择性组胺H2拮抗剂的药理学活性。式（I）化合物中的取代基在本公开的主体中定义。

10. 发明授权

US11608770B2 Hydraulic motor system for liquid transport tank 有权
公开(公告)号：US11608770B2
公开(公告)日：2023-03-21
申请号：US17305220
申请日：2021-07-01
申请人： Roger Hayes
发明人： Roger Hayes
IPC分类号： F01P11/02 , F01P3/12 , F04D29/58 , F01P3/20
摘要： A motor for driving a liquid end of a pump system. The motor having an inner housing having an outer surface, a mechanical actuator disposed in the inner housing, and a water jacket surrounding at least a portion of the outer surface of the inner housing to define a volume between the inner housing and the water jacket. The volume being sized to circulate water within the water jacket so as to transfer heat from the inner housing to the water.

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