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1. 发明授权

US5587292A Diagnosis of fungal infections with a chitinase 失效
标题翻译：用几丁质酶诊断真菌感染
公开(公告)号：US5587292A
公开(公告)日：1996-12-24
申请号：US402772
申请日：1995-03-09
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C12N9/24 , G01N33/569 , G01N33/53 , G01N33/532 , G01N33/536
CPC分类号： C12Y302/01014 , C12N9/2442 , G01N33/56961 , Y10S435/96 , Y10S436/80 , Y10S436/801 , Y10S436/804 , Y10S436/805
摘要： A novel method for detecting chitin, and for diagnosing fungal infections (including yeast infections), with a chitinase or other chitin-specific binding protein. This method should allow the convenient, broad spectrum diagnosis of fungal infections in tissue samples or in body fluids. Fungal infections are a particular problem in immunocompromised hosts such as AIDS patients, where they can cause opportunistic infections. This invention overcomes difficulties experienced by prior methods of diagnosing fungal infections.
摘要翻译：一种用几丁质酶或其他几丁质特异性结合蛋白检测甲壳素和诊断真菌感染（包括酵母菌感染）的新方法。该方法应允许对组织样本或体液中真菌感染的方便，广谱的诊断。真菌感染是免疫功能低下的宿主如艾滋病患者中的特殊问题，在那里它们可引起机会性感染。本发明克服了现有诊断真菌感染方法所遇到的困难。

2. 发明授权

US5935804A Method for detecting eubacteria in biological samples with catalytically inactive murein binding enzymes 失效
标题翻译：用催化无活性的murein结合酶检测生物样品中的真细菌的方法
公开(公告)号：US5935804A
公开(公告)日：1999-08-10
申请号：US823293
申请日：1997-03-21
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C07K14/00 , C12M1/00 , C12N9/24 , C12N9/36 , C12N9/96 , C12Q1/04 , C12Q1/06 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/48 , G01N33/569 , G01N33/573 , C12Q1/02
CPC分类号： C12N9/2462 , C07K14/001 , C12Q1/04 , C12Q1/18 , C12Y302/01017 , G01N33/569 , G01N33/573 , G01N2333/245 , G01N2333/40 , G01N2333/914 , G01N2333/924
摘要： A method for detecting eubacteria in biological samples with catalytically inactive murein binding enzyme is presented. The biological sample may be chemically treated with alkali to cleave peptide bonds in the sample before incubating the sample with the catalytically inactive murein binding enzyme.
摘要翻译：提出了一种利用催化无活性的murein结合酶检测生物样品中真细菌的方法。在将样品与催化无活性的murein结合酶孵育之前，生物样品可以用碱化学处理以切割样品中的肽键。

3. 发明授权

US6093552A Diagnosis of fungal infections with a chitinase 失效
标题翻译：用几丁质酶诊断真菌感染
公开(公告)号：US6093552A
公开(公告)日：2000-07-25
申请号：US770826
申请日：1996-12-20
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C12Q1/34 , G01N33/569 , G01N33/53
CPC分类号： G01N33/56961 , C12Q1/34
摘要： Chitinase fungal diagnostic reagents comprising a chitinase conjugate comprising a chitinase enzyme and a label, the label selected from among a flourescent or a radioactive compound, an enzyme and a dye, the said chitinase fungal diagnostic reagent comprises a substantially pure aqueous solution of said chitinase conjugate; kits for detecting a fungal cell wall glucosamine compound in a biological specimen comprising the chitinase fungal diagnostic reagent and a filter capable of collecting the fungal cell wall glucosamine compound; and methods for detecting a fungal cell wall glucosamine compound in a biological specimen.
摘要翻译：几丁质酶真菌诊断试剂包含几丁质酶偶联物，其包含几丁质酶和标记，选自荧光素或放射性化合物的标签，酶和染料，所述几丁质酶真菌诊断试剂包含基本上纯的所述几丁质酶缀合物的水溶液 ; 用于检测包含几丁质酶真菌诊断试剂的生物样品中的真菌细胞壁葡糖胺化合物的试剂盒和能够收集真菌细胞壁葡糖胺化合物的过滤器; 以及用于检测生物样本中的真菌细胞壁葡糖胺化合物的方法。

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