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    • 8. 发明授权
    • Reagent materials and associated test elements
    • 试剂材料和相关测试元素
    • US08921061B2
    • 2014-12-30
    • US13667057
    • 2012-11-02
    • Roche Diagnostics Operations, Inc.
    • Christopher D. Wilsey
    • C12Q1/54C12Q1/00
    • C12Q1/54C12Q1/006
    • Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
    • 提供试剂材料和相关测试元件。 在一个实施方案中,具有双重功能性的测试元件包括第一辅酶依赖性酶或用于第一酶,第二辅酶依赖性酶或第二酶底物的第一辅酶或底物,以及选自硫代 - NAD,硫代NADP和根据式(I)的化合物。 一方面,第一分析物是羟基丁酸酯,第一种酶是羟基丁酸脱氢酶,第二种分析物是葡萄糖,第二种酶是葡萄糖脱氢酶或葡萄糖氧化酶。 本申请的其它方面涉及独特的试剂材料。 进一步的实施例,形式,对象,特征,优点,方面和优点将从描述和附图中变得显而易见。
    • 9. 发明申请
    • REAGENT MATERIALS AND ASSOCIATED TEST ELEMENTS
    • 试剂材料和相关测试元素
    • US20150140584A1
    • 2015-05-21
    • US14549724
    • 2014-11-21
    • Roche Diagnostics Operations, Inc.
    • Christopher D. Wilsey
    • C12Q1/54
    • C12Q1/54C12Q1/006
    • Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
    • 提供试剂材料和相关测试元件。 在一个实施方案中,具有双重功能性的测试元件包括第一辅酶依赖性酶或用于第一酶,第二辅酶依赖性酶或第二酶底物的第一辅酶或底物,以及选自硫代 - NAD,硫代NADP和根据式(I)的化合物。 一方面,第一分析物是羟基丁酸酯,第一种酶是羟基丁酸脱氢酶,第二种分析物是葡萄糖,第二种酶是葡萄糖脱氢酶或葡萄糖氧化酶。 本申请的其它方面涉及独特的试剂材料。 进一步的实施例,形式,对象,特征,优点,方面和优点将从描述和附图中变得显而易见。
    • 10. 发明申请
    • REAGENT MATERIALS AND ASSOCIATED TEST ELEMENTS
    • 试剂材料和相关测试元素
    • US20140127728A1
    • 2014-05-08
    • US13667057
    • 2012-11-02
    • ROCHE DIAGNOSTICS OPERATIONS, INC.
    • Christopher D. Wilsey
    • C12Q1/54
    • C12Q1/54C12Q1/006
    • Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
    • 提供试剂材料和相关测试元件。 在一个实施方案中,具有双重功能性的测试元件包括第一辅酶依赖性酶或用于第一酶,第二辅酶依赖性酶或第二酶底物的第一辅酶或底物,以及选自硫代 - NAD,硫代NADP和根据式(I)的化合物。 一方面,第一分析物是羟基丁酸酯,第一种酶是羟基丁酸脱氢酶,第二种分析物是葡萄糖,第二种酶是葡萄糖脱氢酶或葡萄糖氧化酶。 本申请的其它方面涉及独特的试剂材料。 进一步的实施例,形式,对象,特征,优点,方面和优点将从描述和附图中变得显而易见。