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1. 发明申请

US20130189685A1 Method for Improved Diagnosis of Dysplasias 有权
标题翻译：改善诊断痰液的方法
公开(公告)号：US20130189685A1
公开(公告)日：2013-07-25
申请号：US13798998
申请日：2013-03-13
申请人： ROCHE MTM LABORATORIES, AG
发明人： Ruediger Ridder , Anja Reichert , Marcus Trunk-Gehmacher , Richard Batrla
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译：本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标记物来改善发育不良诊断的方法。特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。

2. 发明申请

US20130189686A1 Method for Improved Diagnosis of Dysplasias 审中-公开
公开(公告)号：US20130189686A1
公开(公告)日：2013-07-25
申请号：US13799093
申请日：2013-03-13
申请人： Roche MTM Laboratories, AG
发明人： Ruediger Ridder , Anja Reichert , Marcus Trunk-Gehmacher , Richard Batrla
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

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