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1. 发明申请

US20150192587A1 USE OF PROTEIN S100A12 AS A MARKER FOR COLORECTAL CANCER 审中-公开
公开(公告)号：US20150192587A1
公开(公告)日：2015-07-09
申请号：US14463975
申请日：2014-08-20
申请人： Roche Diagnostics Operations, Inc.
发明人： Norbert Wild , Ursula Garczarek , Andrea Geistanger , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Friedemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thierolf
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , C12Q1/6886 , G01N2333/4727 , G01N2333/805 , G01N2333/8146 , G01N2333/9121
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

2. 发明申请

US20140219998A1 ARMET AS A MARKER FOR CANCER 审中-公开
标题翻译： ARMET作为癌症的标记
公开(公告)号：US20140219998A1
公开(公告)日：2014-08-07
申请号：US14251788
申请日：2014-04-14
申请人： Roche Diagnostics Operations, Inc.
发明人： Markus Roessler , Johann Karl , Julia Riedlinger , Ingo Lindner , Michael Tacke
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N33/57423 , G01N33/57484 , G01N2333/475 , G01N2800/52
摘要： Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Further disclosed is a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in the sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：披露了一种有助于评估癌症的方法。更具体地公开了在早期肿瘤蛋白（= ARMET）中转移的精氨酸富集作为不同癌症类型的通用标记物的用途。 ARMET有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如乳腺，卵巢，子宫颈，头颈部，子宫内膜，黑素瘤，膀胱，肾，胰腺，前列腺，食管，胃或胆管癌。进一步公开了一种通过测量样品中的ARMET从个体获得的来自液体样品的癌症的方法。例如，可以将ARMET的测量用于癌症的早期检测或用于进行手术的患者的监视。

3. 发明申请

US20170275381A1 DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BIVALENT BINDING AGENT 审中-公开
公开(公告)号：US20170275381A1
公开(公告)日：2017-09-28
申请号：US15465439
申请日：2017-03-21
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraemi , Monika Soukupova , Michael Tacke
IPC分类号： C07K16/46 , G01N33/531
CPC分类号： C07K16/468 , G01N33/531
摘要： A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.

4. 发明申请

US20160169895A1 FLAP ENDONUCLEASE-1 AS A MARKER FOR CANCER 审中-公开
公开(公告)号：US20160169895A1
公开(公告)日：2016-06-16
申请号：US15046525
申请日：2016-02-18
申请人： Roche Diagnostics Operations, Inc.
发明人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/54306 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57449 , G01N33/57488 , G01N2333/922 , G01N2800/52 , G01N2800/7028 , G16H50/30 , Y02A90/26
摘要： Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal.

5. 发明申请

US20170115294A1 USE OF PROTEIN S100A12 AS A MARKER FOR COLORECTAL CANCER 审中-公开
公开(公告)号：US20170115294A1
公开(公告)日：2017-04-27
申请号：US15399801
申请日：2017-01-06
申请人： Roche Diagnostics Operations, Inc.
发明人： Norbert Wild , Ursula Garczarek , Andrea Geistanger , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Freidemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thierolf
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , C12Q1/6886 , G01N2333/4727 , G01N2333/805 , G01N2333/8146 , G01N2333/9121
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

6. 发明申请

US20160377625A1 ARMET AS A MARKER FOR CANCER 审中-公开
标题翻译： ARMET作为癌症的标记
公开(公告)号：US20160377625A1
公开(公告)日：2016-12-29
申请号：US15259392
申请日：2016-09-08
申请人： Roche Diagnostics Operations, Inc.
发明人： Markus Roessler , Johann Karl , Julia Riedlinger , Ingo Lindner , Michael Tacke
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N33/57423 , G01N33/57484 , G01N2333/475 , G01N2800/52
摘要： Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Further disclosed is a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in the sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：披露了一种有助于评估癌症的方法。更具体地公开了在早期肿瘤蛋白（= ARMET）中转移的精氨酸富集作为不同癌症类型的通用标记物的用途。 ARMET有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如乳腺，卵巢，子宫颈，头颈部，子宫内膜，黑素瘤，膀胱，肾，胰腺，前列腺，食管，胃或胆管癌。进一步公开了一种通过测量样品中的ARMET从个体获得的来自液体样品的癌症的方法。例如，可以将ARMET的测量用于癌症的早期检测或用于进行手术的患者的监视。

7. 发明授权

US10982007B2 Detection of a posttranslationally modified polypeptide by a bivalent binding agent 有权
公开(公告)号：US10982007B2
公开(公告)日：2021-04-20
申请号：US15465439
申请日：2017-03-21
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
IPC分类号： C07K16/46 , G01N33/531
摘要： A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.

8. 发明申请

US20170275380A1 DETECTION OF A POLYPEPTIDE DIMER BY A BIVALENT BINDING AGENT 审中-公开
公开(公告)号：US20170275380A1
公开(公告)日：2017-09-28
申请号：US15465379
申请日：2017-03-21
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Gerg , Dieter Heindl , Alfred Mertens , Christoph Rutz , Michael Schraemi , Monika Soukupova , Claudio Sustmann , Michael Tacke , Jan van Dieck
IPC分类号： C07K16/46 , C07K16/28 , C07K16/44 , G01N33/68 , C07K16/18 , C07K16/32
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/44 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/92 , C07K2317/94 , G01N33/6857
摘要： A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10−3/sec to 10−4/sec, and the bivalent binding agent has a Kdiss of 3×10−5/sec or less. Methods of making and using such bivalent binding agent in histological staining procedures are also disclosed.

9. 发明申请

US20150072355A1 FLAP ENDONUCLEASE-1 AS A MARKER FOR CANCER 审中-公开
标题翻译： FLAP ENDONUCLEASE-1作为癌症标记
公开(公告)号：US20150072355A1
公开(公告)日：2015-03-12
申请号：US14529702
申请日：2014-10-31
申请人： Roche Diagnostics Operations, Inc.
发明人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
IPC分类号： G01N33/543 , G06F19/00
CPC分类号： G01N33/573 , G01N33/54306 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57449 , G01N33/57488 , G01N2333/922 , G01N2800/52 , G01N2800/7028 , G16H50/30 , Y02A90/26
摘要： Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal.
摘要翻译：提供了帮助评估癌症的方法，包括使用Flap核酸内切酶-1蛋白（= FEN1）作为不同癌症类型的通用标记。特别地，公开了从样品中得到的来自个体的液体样品中评估癌症的方法，其包括测量样品中的FEN1。 FEN1的测量可用于癌症的早期检测或用于手术切除肿瘤的患者的监测。

10. 发明申请

US20130288267A1 DETECTION OF A POLYPEPTIDE DIMER BY A BIVALENT BINDING AGENT 审中-公开
标题翻译：通过双重结合剂检测多肽二聚体
公开(公告)号：US20130288267A1
公开(公告)日：2013-10-31
申请号：US13923646
申请日：2013-06-21
申请人： Roche Diagnostics Operations, Inc.
发明人： Michael Gerg , Dieter Heindl , Alfred Mertens , Christoph Rutz , Michael Schraeml , Monika Soukupova , Claudio Sustmann , Michael Tacke , Jan van Dieck
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/44 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/92 , C07K2317/94 , G01N33/6857
摘要： A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10−3/sec to 10−4/sec, and the bivalent binding agent has a Kdiss of 3×10−5/sec or less. Methods of making and using such bivalent binding agent in histological staining procedures are also disclosed.
摘要翻译：能够结合多肽二聚体的二价结合剂，其由通过接头彼此连接的两个单价结合物组成，所述第一单价键合物结合包含在所述二聚体中的第一目标多肽的表位，并且所述第二单价键合物结合表位的包含在所述二聚体中的第二目标多肽。每个一价粘合剂的Kdiss在5×10-3 /秒至10-4 /秒的范围内，二价结合剂的Kdiss为3×10-5 /秒或更小。还公开了在组织学染色方法中制备和使用这种二价结合剂的方法。

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