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1. 发明授权

US08580543B2 Microorganisms and methods for the biosynthesis of butadiene 有权
标题翻译：用于生物合成丁二烯的微生物和方法
公开(公告)号：US08580543B2
公开(公告)日：2013-11-12
申请号：US13101046
申请日：2011-05-04
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/20 , C12N1/00
CPC分类号： C12P5/026 , C07C11/16 , C08F136/06 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
摘要翻译：本发明提供具有丁二烯途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产丁二烯的方法。

2. 发明申请

US20130144029A1 MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE 有权
公开(公告)号：US20130144029A1
公开(公告)日：2013-06-06
申请号：US13668117
申请日：2012-11-02
申请人： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Mark J. Burk
发明人： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Mark J. Burk
IPC分类号： C12P17/08 , C07D313/04 , C12N15/63
CPC分类号： C12P17/08 , C07D313/04 , C08G18/4277 , C08G63/08 , C12N5/0018 , C12N15/52 , C12N15/63 , C12N15/70 , C12P17/02
摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

3. 发明申请

US20120225466A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 有权
标题翻译：二苯乙烯生物合成的微生物和方法
公开(公告)号：US20120225466A1
公开(公告)日：2012-09-06
申请号：US13365132
申请日：2012-02-02
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/19 , C12N1/15 , C12N1/21
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
摘要翻译：本发明提供具有丁二烯途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产丁二烯的方法。

4. 发明申请

US20110014668A1 ORGANISMS FOR THE PRODUCTION OF CYCLOHEXANONE 有权
标题翻译：生产环己酮的有机体
公开(公告)号：US20110014668A1
公开(公告)日：2011-01-20
申请号：US12780802
申请日：2010-05-14
申请人： Robin E. Osterhout , Anthony P. Burgard , Mark J. Burk , Priti Pharkya
发明人： Robin E. Osterhout , Anthony P. Burgard , Mark J. Burk , Priti Pharkya
IPC分类号： C12P7/26 , C12N1/00
CPC分类号： C12P7/26 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12N15/70
摘要： A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase, a 4-acetylbutyrate dehydratase, a 3-hydroxycyclohexanone dehydrogenase, a 2-cyclohexenone hydratase, a cyclohexanone dehydrogenase and an enzyme selected from a 3-oxopimeloyl-CoA synthetase, a 3-oxopimeloyl-CoA hydrolase (acting on thioester), and a 3-oxopimeloyl-coA transferase. Each these pathways can include a PEP carboxykinase. A method for producing cyclohexanone includes culturing these non-naturally occurring microbial organisms.
摘要翻译：非天然存在的微生物有机体具有包含至少一种编码环己酮途径酶的外源核酸的环己酮途径。途径包括2-酮环己烷-1-羧基-CoA水解酶（作用于C-C键），2-酮环己烷-1-羧酸脱羧酶和选自2-酮环己烷-1-羧基-CoA水解酶的酶（作用在硫酯上），2-酮环己烷-1-羧基-CoA转移酶和2-酮环己烷-1-羧基-CoA合成酶。途径包括选自6-酮环己-1-烯-1-羧基-CoA水解酶（作用于C-C键）的酶，6-酮环己-1-烯-1-羧基-CoA合成酶，6- 酮酮环己-1-烯-1-羧基-CoA水解酶（作用于硫酯），6-酮环己-1-烯-1-羧基-CoA转移酶，6-酮环己-1-烯-1-羧基-CoA还原酶， 6-酮环己-1-烯-1-羧酸脱羧酶，6-酮环己-1-烯-1-羧酸还原酶，2-酮环己烷-1-羧基-CoA合成酶，2-酮环己烷-1-羧基-CoA 转移酶，2-酮环己烷-1-羧基-CoA水解酶（作用于硫酯），2-酮环己烷-1-羧酸脱羧酶和环己酮脱氢酶。途径包括己二酸半醛脱水酶，环己烷-1,2-二醇脱氢酶和环己烷-1,2-二醇脱水酶。途径包括3-氧代邻苯二甲酸脱羧酶，4-乙酰基丁酸脱水酶，3-羟基环己酮脱氢酶，2-环己烯酮水合酶，环己酮脱氢酶和选自3-氧代木糖酰辅酶A合成酶，3-氧代木糖酰-CoA水解酶（作用于硫酯）和3-氧代木糖酰辅酶A转移酶。每个这些途径可以包括PEP羧基激酶。生产环己酮的方法包括培养这些非天然存在的微生物。

5. 发明授权

US08715957B2 Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene 有权
标题翻译：用于生物合成芳烃，2,4-戊二烯酸和1,3-丁二烯的微生物和方法
公开(公告)号：US08715957B2
公开(公告)日：2014-05-06
申请号：US13191375
申请日：2011-07-26
申请人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
IPC分类号： C12P1/00 , A61K38/00
CPC分类号： C12P7/62 , C12N15/52 , C12P5/005 , C12P5/026 , C12P7/16 , C12P7/40 , C12P9/00 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
摘要翻译：本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。

6. 发明申请

US20130066035A1 EUKARYOTIC ORGANISMS AND METHODS FOR INCREASING THE AVAILABILITY OF CYTOSOLIC ACETYL-COA, AND FOR PRODUCING 1,3-BUTANEDIOL 审中-公开
标题翻译：用于增加CYPOSOLIC ACETYL-COA和生产1,3-丁二醇的可用性的原始有机体和方法
公开(公告)号：US20130066035A1
公开(公告)日：2013-03-14
申请号：US13607527
申请日：2012-09-07
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya , Jingyi Li
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya , Jingyi Li
IPC分类号： C12N1/19 , C12Q1/32 , C08G63/00 , C07C31/20 , C08G18/32 , C12N1/15 , C12P7/18
CPC分类号： C12N15/52 , C08G63/16 , C12N1/14 , C12N1/16 , C12N1/20 , C12P7/18 , C12P19/32
摘要： Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-CoA. Also provided herein are non-naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-BDO) pathway. and methods of using such organisms to produce 1,3-BDO.
摘要翻译：本文提供的是非天然存在的真核生物，其可被工程化以产生和增加细胞溶质乙酰辅酶A的可用性。本文还提供具有1,3-丁二醇（1,3-BDO）途径的非天然存在的真核生物。以及使用这些生物体产生1,3-BDO的方法。

7. 发明申请

US20130011891A1 MICROORGANISMS FOR PRODUCING BUTADIENE AND METHODS RELATED THERETO 有权
标题翻译：用于生产二苯乙烯的微生物及其相关方法
公开(公告)号：US20130011891A1
公开(公告)日：2013-01-10
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/15 , C12N1/19 , C12P7/04 , C12N1/21
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

8. 发明申请

US20120282661A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 审中-公开
标题翻译：丙二酸，十六烷二胺和6-氨基酸的生物合成的微生物和方法
公开(公告)号：US20120282661A1
公开(公告)日：2012-11-08
申请号：US13549239
申请日：2012-07-13
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P13/00 , C12N15/52 , C12N1/15 , C12N1/21 , C12P17/10 , C12N1/19
CPC分类号： C12P17/10 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/12
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
摘要翻译：本发明提供了具有6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径的非天然存在的微生物生物。微生物生物体含有至少一种编码各自的6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径中的酶的外源核酸。本发明另外提供了制备6-氨基己酸，己内酰胺，己二胺或乙酰丙酸的方法。该方法可以包括培养6-氨基己酸，己内酰胺或六亚甲基二胺生产微生物，其中微生物生物体表达至少一种编码6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径酶的外源核酸，其量足以产生各自的产物在条件下和足够的时间内产生6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸。

9. 发明申请

US20120276604A1 MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 有权
标题翻译：用于生产甲基丙烯酸的微生物
公开(公告)号：US20120276604A1
公开(公告)日：2012-11-01
申请号：US13531377
申请日：2012-06-22
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P7/42 , C12N1/21
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N9/90 , C12P7/40 , C12Y102/01 , C12Y206/01022 , C12Y403/01 , C12Y504/99002
摘要： The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
摘要翻译：本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物生物。微生物生物体含有编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中的酶的至少一种外源核酸。本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并培养在条件下和足够的时间内产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸。

10. 发明申请

US20120021478A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE 有权
标题翻译：芳香族化合物的2,4-二戊二酸和1,3-丁二烯的生物合成的微生物和方法
公开(公告)号：US20120021478A1
公开(公告)日：2012-01-26
申请号：US13191375
申请日：2011-07-26
申请人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
IPC分类号： C12P5/02 , C12N1/00
CPC分类号： C12P7/62 , C12N15/52 , C12P5/005 , C12P5/026 , C12P7/16 , C12P7/40 , C12P9/00 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
摘要翻译：本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。

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