专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100105711A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20100105711A1
公开(公告)日：2010-04-29
申请号：US12556964
申请日：2009-09-10
申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet
发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet
IPC分类号： A61K31/4439 , C07D417/14 , A61K31/506 , A61P43/00
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变态化的疾病中的组合物和用途。

2. 发明授权

US08940771B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US08940771B2
公开(公告)日：2015-01-27
申请号：US12338432
申请日：2008-12-18
申请人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Vito Guagnano , Patricia Imbach
发明人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Vito Guagnano , Patricia Imbach
IPC分类号： A61K31/4439 , A61K31/427 , C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , C07D417/12
摘要： The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。

3. 发明授权

US08227462B2 Pyrrolidine-1,2-dicarboxamide derivatives 有权
标题翻译：吡咯烷-1,2-二甲酰胺衍生物
公开(公告)号：US08227462B2
公开(公告)日：2012-07-24
申请号：US12556964
申请日：2009-09-10
申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet
发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet
IPC分类号： C07D417/14 , A61K31/4439
CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14
摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变性的疾病中的组合物和用途。

4. 发明申请

US20090163469A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20090163469A1
公开(公告)日：2009-06-25
申请号：US12338432
申请日：2008-12-18
申请人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Vito Guagnano , Patricia Imbach
发明人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Vito Guagnano , Patricia Imbach
IPC分类号： A61K31/397 , C07D277/38 , A61K31/426 , C07D417/14 , C07D223/14 , A61P35/00 , A61P37/00 , A61P3/00 , A61P17/00 , A61K31/55 , A61K31/506 , A61K31/4439 , A61K31/496
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , C07D417/12
摘要： The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变质的疾病中的组合物和用途。

5. 发明申请

US20080312192A1 Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases 审中-公开
标题翻译：二芳基脲衍生物在蛋白激酶依赖性疾病的治疗中的应用
公开(公告)号：US20080312192A1
公开(公告)日：2008-12-18
申请号：US10580259
申请日：2004-11-26
申请人： Guido Bold , Giorgio Caravatti , Andreas Floersheimer , Vito Guagnano , Patricia Imbach , Keiichi Masuya , Johannes Roesel , Andrea Vaupel , Carlos Garcia-Echeverria
发明人： Guido Bold , Giorgio Caravatti , Andreas Floersheimer , Vito Guagnano , Patricia Imbach , Keiichi Masuya , Johannes Roesel , Andrea Vaupel , Carlos Garcia-Echeverria
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/513 , A61K31/655 , A61K31/506
CPC分类号： C04B35/632 , C07D239/34 , C07D239/47 , C07D401/12 , C07D403/12
摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumour diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N′-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N′-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N′-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.
摘要翻译：本发明涉及二芳基脲衍生物在制备用于治疗RET依赖性疾病，特别是RET依赖性肿瘤疾病的药物组合物中的用途。本发明还涉及新的N- [4-（嘧啶-4-基氧基） - 苯基] -N'-苯基 - 脲衍生物及其在治疗动物或人体中的用途，特别是在治疗蛋白激酶涉及包含这种新型N- [4-（嘧啶-4-基氧基） - 苯基] -N'-苯基 - 脲衍生物的药物组合物和使用这种新型的N- [4-（嘧啶-4-基氧基） - 苯基] -N'-苯基 - 脲衍生物，用于制备用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病如肿瘤疾病的药物组合物。

6. 发明申请

US20050239716A1 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives 审中-公开
标题翻译： 2 - {[N-（2-氨基-3-（杂芳基或芳基）丙酰基） - 氨基酰基] - 氨基} - 烷基硼酸衍生物
公开(公告)号：US20050239716A1
公开(公告)日：2005-10-27
申请号：US11172146
申请日：2005-06-30
申请人： Pascal Furet , Vito Guagnano , Patricia Imbach , Marc Lang
发明人： Pascal Furet , Vito Guagnano , Patricia Imbach , Marc Lang
IPC分类号： A61K38/00 , A61P35/00 , A61P43/00 , C07K5/06 , C07F5/02 , A61K38/04
CPC分类号： C07K5/06191 , A61K38/00
摘要： The present invention relates to compounds of formula I wherein the substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical preparations comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译：本发明涉及式I化合物，其中取代基如说明书中所定义，其制备方法，包含那些化合物的药物制剂及其在制备用于治疗温热的药物组合物中的用途动物，包括人类。

7. 发明申请

US20100311729A1 Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors 审中-公开
标题翻译：取代的咪唑并哒嗪和吡咯并嘧啶作为脂质激酶抑制剂
公开(公告)号：US20100311729A1
公开(公告)日：2010-12-09
申请号：US12599143
申请日：2008-05-09
申请人： Hans-Georg Capraro , Patricia Imbach , Giorgio Caravatti , Pascal Furet , Jiong Lan , Sabrina Pecchi , Joseph Schoepfer
发明人： Hans-Georg Capraro , Patricia Imbach , Giorgio Caravatti , Pascal Furet , Jiong Lan , Sabrina Pecchi , Joseph Schoepfer
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/5025 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds are of the formula I, processes for the preparation thereof, more generally these compounds for use in the treatment of the human or animal body, in the treatment of an inflammatory or obstructive airway disease, disorders commonly occurring in connection with transplantation, or a proliferative disease, which disease responds to an inhibition of kinases of the PI3-kinase-related protein kinase family.
摘要翻译：本发明涉及式I化合物，其制备方法，更一般地，这些用于治疗人或动物体的化合物，用于治疗炎性或阻塞性气道疾病，通常在连接中发生的疾病移植或增殖性疾病，该疾病对PI3激酶相关蛋白激酶家族的激酶的抑制作出反应。

8. 发明申请

US20060106027A1 Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yI)-amine derivatives 失效
标题翻译：苯基 - [4-（3-苯基-1H-吡唑-4-基） - 嘧啶-2-基） - 胺衍生物
公开(公告)号：US20060106027A1
公开(公告)日：2006-05-18
申请号：US10520567
申请日：2003-07-08
申请人： Pascal Furet , Patricia Imbach , Timothy Ramsey , Achim Schlapbach , Dieter Scholz , Giorgio Caravatti
发明人： Pascal Furet , Patricia Imbach , Timothy Ramsey , Achim Schlapbach , Dieter Scholz , Giorgio Caravatti
IPC分类号： A61K31/506 , C07D403/14 , C07D403/02
CPC分类号： C07D403/04 , A61K31/505
摘要： The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译：本发明涉及苯基 - [4-（3-苯基-1H-吡唑-4-基） - 嘧啶-2-基] - 胺衍生物及其制备方法，涉及包含这些衍生物的药物组合物及其用途的这样的衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病例如肿瘤的药物组合物。

9. 发明授权

US06767906B2 2-amino-6-anilino-purines and their use as medicaments 失效
标题翻译： 2-氨基-6-苯胺基嘌呤及其作为药物的用途
公开(公告)号：US06767906B2
公开(公告)日：2004-07-27
申请号：US09927322
申请日：2001-08-10
申请人： Patricia Imbach , Hans-Georg Capraro , Jürg Zimmermann , Giorgio Caravatti , Pascal Furet , Wolfgang Karl-Diether Brill
发明人： Patricia Imbach , Hans-Georg Capraro , Jürg Zimmermann , Giorgio Caravatti , Pascal Furet , Wolfgang Karl-Diether Brill
IPC分类号： C07D47316
CPC分类号： C07D473/16 , C07D473/40
摘要： This application discloses 2-amino-6-anilino-purine derivatives of the formula I in which q is 1-5, and R1 is &agr;) —S(═O)k—NR6R7, in which k is 1 or 2, wherein under the proviso that R6 and R7 cannot be simultaneously hydrogen &agr;1) R6, R7 can be identical or different from one another and represent an aliphatic, carbocyclic, heterocyclic, carbocyclic-aliphatic or heterocyclic-aliphatic radical; hydrogen or lower aliphatic acyl; or &agr;2) R6 and R7 together are an alkylene or alkenylene radical having from 3 up to and including 9 C atoms, in which 1-3 C atoms can be replaced by oxygen, sulfur or nitrogen, &bgr;) N-(aryl lower alkyl)carbamoyl, or &ggr;) a radical of the formula —NH—S(═O)i—R8, in which i is 1 or 2, R8 is an aliphatic, carbocyclic or heterocyclic radical; or &dgr;) a radical of the formula —NH—C(═O)—R9, and the other variable substituents are as defined herein. The inventive compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumour diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.
摘要翻译：本申请公开了式Iin的2-氨基-6-苯胺基 - 嘌呤衍生物，其中q是1-5，和R1是α）-S（= O）k-NR6R7，其中k是1或2，其中在条件是R6和 R7不能同时为氢α1）R6，R7可以相同或不同，代表脂族，碳环，杂环，碳环脂族或杂环脂族基; 氢或低级脂族酰基; 口服α2）R6和R7一起是具有3个至多且包括9个C原子的亚烷基或亚烯基，其中1-3个C原子可以被氧，硫或氮取代，β）N-（芳基低级烷基）氨基甲酰基（= O）i-R8的基团，其中i为1或2，R8为脂族，碳环或杂环基; 顺式）式-NH-C（= O）-R9的基团，其它可变取代基如本文所定义。本发明化合物抑制p34 /细胞周期蛋白B 激酶和蛋白酪氨酸激酶pp60 ，并且可用于治疗过度增殖性疾病，例如肿瘤疾病和对抑制活性的疾病蛋白酪氨酸激酶pp60 ，特别是骨质疏松症。

10. 发明授权

US06933290B2 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives 失效
标题翻译： 2- {N-（2-氨基-3-（杂芳基或芳基）丙酰基） - 氨基酰基} - 氨基} - 烷基硼酸衍生物
公开(公告)号：US06933290B2
公开(公告)日：2005-08-23
申请号：US10478794
申请日：2002-05-29
申请人： Pascal Furet , Vito Guagnano , Patricia Imbach , Marc Lang
发明人： Pascal Furet , Vito Guagnano , Patricia Imbach , Marc Lang
IPC分类号： A61K38/00 , A61P35/00 , A61P43/00 , C07K5/06 , A61K31/69 , A61K38/05 , C07K5/08
CPC分类号： C07K5/06191 , A61K38/00
摘要： Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans
摘要翻译：公开了2 - {[N-（2-氨基-3-（杂芳基或芳基）丙酰基） - 氨基酰基] - 氨基} - 烷基硼酸的衍生物，这些化合物的制备方法，药物制剂及其用途制备用于治疗温血动物（包括人）的药物组合物的衍生物

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式