专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5177109A 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders 失效
标题翻译：用于治疗中枢神经系统疾病的2-氨基-4,5-亚甲基己二酸化合物
公开(公告)号：US5177109A
公开(公告)日：1993-01-05
申请号：US732881
申请日：1991-07-19
申请人： Roberto Pellicciari , Benedetto Natalini , Maura Marinozzi , Alexis A. Cordi , Joseph B. Monahan , Thomas H. Lanthorn
发明人： Roberto Pellicciari , Benedetto Natalini , Maura Marinozzi , Alexis A. Cordi , Joseph B. Monahan , Thomas H. Lanthorn
IPC分类号： C07C229/46 , C07C233/48 , C07C271/22
CPC分类号： C07C229/46 , C07C233/48 , C07C271/22 , C07C2101/02
摘要： Compounds, compositions and methods are described for treating a CNS disorder such as a cognitive disorder, epilepsy, depression, Parkinson's disease, Alzheimer's disease, a neurodegenerative disease or neurotoxic injury. Compound of interest are 2-amino-4,5-methyleneadipic acid compounds and derivatives defined by the formula I: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, arylthioalkyl, ##STR2## with each of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein each of X and Y is independently selected from hydroxyl, alkoxy, alkylthio, amino and ##STR3## with each of R.sup.6 and R.sup.7 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein any of R.sup.1 through R.sup.7 groups having a substitutable position may be substituted with one or more substituents selected from hydroxyl, halo, alkyl, haloalkyl, cyano, alkoxy, alkylthio, sulfinyl, sulfonyl, sulfinylalkyl, sulfonylalkyl, amino, acyl, acyloxy, alkoxycarbonyl and aminocarbonyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了用于治疗中枢神经系统疾病如认知障碍，癫痫，抑郁症，帕金森病，阿尔茨海默病，神经变性疾病或神经毒性损伤的化合物，组合物和方法。化合物是2-氨基-4,5-亚甲基己二酸化合物和由式I定义的衍生物：其中R 1选自氢，烷基，环烷基，芳烷基，芳氧基烷基，芳硫基烷基， R2，R3，R4和R5各自独立地选自氢，烷基，环烷基，芳基和芳烷基; 其中X和Y各自独立地选自羟基，烷氧基，烷硫基，氨基和每个R 6和R 7各自独立地选自氢，烷基，环烷基，芳基和芳烷基; 其中具有可取代位置的R 1至R 7基团中的任何一个可以被一个或多个选自羟基，卤素，烷基，卤代烷基，氰基，烷氧基，烷硫基，亚磺酰基，磺酰基，亚磺酰基烷基，磺酰基烷基，氨基，酰基，酰氧基，烷氧基羰基和氨基羰基; 或其药学上可接受的盐。

2. 发明授权

US4738979A .alpha..sub.2 -blocking derivatives of imidazole 失效
标题翻译：咪唑的α2-阻断衍生物
公开(公告)号：US4738979A
公开(公告)日：1988-04-19
申请号：US823157
申请日：1986-01-27
申请人： Piedad Calderon , Alexis A. Cordi , Claude L. Gillet , Hugo J. Gorissen , Georges E. Lambelin , Joseph L. Roba , Michel P. Snyers , William R. van Dorsser
发明人： Piedad Calderon , Alexis A. Cordi , Claude L. Gillet , Hugo J. Gorissen , Georges E. Lambelin , Joseph L. Roba , Michel P. Snyers , William R. van Dorsser
IPC分类号： A61K31/415 , A61P1/04 , A61P3/04 , A61P3/08 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/24 , A61P25/26 , C07C17/00 , C07C45/63 , C07C47/24 , C07D233/54 , C07D233/58 , C07D233/62 , C07D233/64 , C07D233/84
CPC分类号： C07D233/64 , C07C17/35 , C07C45/63 , C07C47/24 , C07D233/56
摘要： A compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2, whether or not identical are hydrogen, a halogen such as fluoro, chloro or bromo, linear or branched alkyl of 1 to 3 carbon atoms, linear or branched alkoxy of 1 to 3 carbon atoms, carboxy, alkoxy-carbonyl of 1 to 3 carbon atoms or phenyl;R.sup.1 is hydrogen, methyl or phenyl;R.sup.2 and R.sup.3, which may or may not be identical, are hydrogen, hydroxyl, linear or branched alkyl of 1 to 6 carbon atoms, or linear or branched alkoxy group of 1 to 4 carbon atoms;R.sup.1 and R.sup.2 may together form a carbon-carbon double bond; andR.sup.4 and R.sup.5 whether or not identical, are hydrogen, linear or branched alkyl or 1 to 3 carbon atoms.The compounds are useful as blocking agents of .alpha..sub.2 -adrenergic receptors.
摘要翻译：具有下式的化合物：其中X1，X2，Y1和Y2，无论相同还是不相同的是氢，卤素如氟，氯或溴，直链或支链的直链或支链烷基，直链或支链 1至3个碳原子的烷氧基，1至3个碳原子的羧基，烷氧基 - 羰基或苯基; R1是氢，甲基或苯基; R2和R3可以是或不相同的是具有1至6个碳原子的氢，羟基，直链或支链烷基或具有1至4个碳原子的直链或支链烷氧基; R1和R2可以一起形成碳 - 碳双键; 和R4和R5是否相同，是氢，直链或支链烷基或有1到3个碳原子。该化合物可用作α2-肾上腺素能受体的阻断剂。

3. 发明授权

US4997821A Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury 失效
标题翻译：可用于减少神经毒性损伤的膦酰基 - 异喹啉化合物
公开(公告)号：US4997821A
公开(公告)日：1991-03-05
申请号：US260839
申请日：1988-10-21
申请人： Alexis A. Cordi , Michael L. Vazquez
发明人： Alexis A. Cordi , Michael L. Vazquez
IPC分类号： C07F9/40 , C07F9/62
CPC分类号： C07F9/4021 , C07F9/62
摘要： A class of phosphono-hydroisoquinoline componds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phosphono-hydroisoquinoline compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1 through R.sup.4 is hydrido, each of Z.sup.1 and Z.sup.2 is hydroxyl and wherein the A ring is aromatic.
摘要翻译：描述了一类膦酰基 - 氢异喹啉化合物用于治疗，以减少与缺氧或缺血相关的神经毒性损伤，其通常在中风，心脏骤停或围产期窒息之后。该治疗包括单独施用膦酰基 - 氢异喹啉化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中R 1至R 4各自为氢，Z 1和Z 2各自为羟基，并且其中A环为芳族化合物。

4. 发明授权

US5302586A Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury 失效
标题翻译：膦酰基甲基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物，用于治疗神经毒性损伤
公开(公告)号：US5302586A
公开(公告)日：1994-04-12
申请号：US982819
申请日：1992-11-30
申请人： Alexis A. Cordi , Eric T. Sun
发明人： Alexis A. Cordi , Eric T. Sun
IPC分类号： C07F9/6561 , A61K31/505 , C07F9/09
CPC分类号： C07F9/6561
摘要： A class of phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest, hypoglycemia or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.6 is independently selected from hydrido, alkyl, allyl, cycloalkyl, cycloalkylalkyl, phenyl and benzyl; wherein Y.sub.m is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --; where m is one; wherein x is one or more groups attachable at one or more of the 5-, 6- and 7-ring positions of the imidazo[1,2-a]pyrimidine ring system; wherein each x and T is independently selected from hydrido, halo, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, alkenyl, alkynyl, phenyl, benzyl, hydroxy, hydroxyalkyl, alkoxy, phenoxy, alkoxyalkyl, benzyloxy, cyano, alkanoyl, alkylthio, arylthio and amino; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类膦酰基甲基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物用于治疗，以减少与缺氧或缺血相关的神经毒性损伤，其通常在中风，心脏骤停，低血糖或围产期窒息之后。治疗包括单独施用该类化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中R 1，R 2和R 6各自独立地选自氢，烷基，烯丙基，环烷基，环烷基烷基，苯基和苄基; 其中Ym是-CH 2 - 或-CH 2 -CH 2 - ; 哪里是一个; 其中x是在咪唑并[1,2-a]嘧啶环系统的一个或多个5-，6-和7-环位置可连接的一个或多个基团; 其中每个x和T独立地选自氢，卤素，烷基，环烷基，环烷基烷基，卤代烷基，烯基，炔基，苯基，苄基，羟基，羟烷基，烷氧基，苯氧基，烷氧基烷基，苄氧基，氰基，烷酰基，烷硫基，芳硫基和氨基 ; 或其药学上可接受的盐。

5. 发明授权

US5141960A Tricyclic glycinamide derivatives as anti-convulsants 失效
标题翻译：三环甘氨酰胺衍生物作为抗惊厥药
公开(公告)号：US5141960A
公开(公告)日：1992-08-25
申请号：US720337
申请日：1991-06-25
申请人： Alexis A. Cordi , Claude L. Gillet
发明人： Alexis A. Cordi , Claude L. Gillet
IPC分类号： C07C237/06 , C07D337/12
CPC分类号： C07C237/06 , C07D337/12 , C07C2103/32
摘要： A class of tricyclic glycinamide derivatives is described having use in treatment of CNS dysfunctions such as epilepsy and convulsive disorders. Compounds of most interest are those of the formula ##STR1## wherein each of X and Y is hydrido; wherein Z is selected from methylene, ethylene, ethenylene, thiomethylene and thioethylene; and wherein each of R.sup.1, R.sup.2 and R.sup.3 is hydrido; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类用于治疗CNS功能障碍如癫痫和惊厥性疾病的三环甘氨酰胺衍生物。最令人感兴趣的化合物是下式的化合物：其中X和Y各自是氢的; 其中Z选自亚甲基，亚乙基，亚乙烯基，亚甲基和硫代亚乙基; 并且其中R1，R2和R3各自是氢的; 或其药学上可接受的盐。

6. 发明授权

US5958904A Phosphonomethyl-imidazo�1,2-A! pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury 失效
标题翻译：用于治疗神经毒性损伤的膦酰基甲基 - 咪唑并[1,2-A]嘧啶-2-羧酸化合物
公开(公告)号：US5958904A
公开(公告)日：1999-09-28
申请号：US46885
申请日：1998-03-24
申请人： Alexis A. Cordi , Eric T. Sun
发明人： Alexis A. Cordi , Eric T. Sun
IPC分类号： C07F9/6561 , A61K31/675 , A61K31/505
CPC分类号： C07F9/6561
摘要： A method is described to prevent neural cell injury by use of a compound from a class of phosphonometyl-imidazo�1,2-a!pyrimidine-2-carboxylic acid compounds. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein Y.sub.m is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --; where m is one; wherein X is one or more groups attachable at one or more of the 5-, 6- and 7-ring positions of the imidazo�1,2-a!pyrimidine ring system; wherein each X and T is independently selected from hydrido, halo, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, alkenyl, alkynyl, phenyl, benzyl, hydroxy, hydroxyalkyl, alkoxy, phenoxy, alkoxyalkyl, benzyloxy, cyano, alkanoyl, alkylthio, arylthio and amino; wherein each of R.sup.1, R.sup.2 and R.sup.6 is independently selected from hydrido, alkyl, allyl, cycloalkyl, cycloalkylalkyl, phenyl and benzyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一种通过使用一类膦酰基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物的化合物来预防神经细胞损伤的方法。治疗包括单独施用该类化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中Ym是-CH2-或-CH2-CH2-; 哪里是一个; 其中X是在咪唑并[1,2-a]嘧啶环体系的一个或多个5-，6-和7-环位置可连接的一个或多个基团; 其中每个X和T独立地选自氢，卤素，烷基，环烷基，环烷基烷基，卤代烷基，烯基，炔基，苯基，苄基，羟基，羟基烷基，烷氧基，苯氧基，烷氧基烷基，苄氧基，氰基，烷酰基，烷硫基，芳硫基和氨基 ; 其中R 1，R 2和R 6各自独立地选自氢，烷基，烯丙基，环烷基，环烷基烷基，苯基和苄基; 或其药学上可接受的盐。

7. 发明授权

US5482933A Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury 失效
标题翻译：膦酰基甲基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物，用于治疗神经毒性损伤
公开(公告)号：US5482933A
公开(公告)日：1996-01-09
申请号：US140370
申请日：1993-10-21
申请人： Alexis A. Cordi , Eric T. Sun
发明人： Alexis A. Cordi , Eric T. Sun
IPC分类号： C07F9/6561 , A61K31/675 , A61K31/505
CPC分类号： C07F9/6561
摘要： A class of phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest, hypoglycemia or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.6 is independently selected from hydrido, alkyl, allyl, cycloalkyl, cycloalkylalkyl, phenyl and benzyl; wherein Y.sub.m is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --; where m is one; wherein X is one or more groups attachable at one or more of the 5-, 6- and 7-ring positions of the imidazo[1,2-a]pyrimidine ring system; wherein each X and T is independently selected from hydrido, halo, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, alkenyl, alkynyl, phenyl, benzyl, hydroxy, hydroxyalkyl, alkoxy, phenoxy, alkoxyalkyl, benzyloxy, cyano, alkanoyl, alkylthio, arylthio and amino; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类膦酰基甲基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物用于治疗，以减少与缺氧或缺血相关的神经毒性损伤，其通常在中风，心脏骤停，低血糖或围产期窒息之后。治疗包括单独施用该类化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中R 1，R 2和R 6各自独立地选自氢，烷基，烯丙基，环烷基，环烷基烷基，苯基和苄基; 其中Ym是-CH 2 - 或-CH 2 -CH 2 - ; 哪里是一个; 其中X是在咪唑并[1,2-a]嘧啶环体系的一个或多个5-，6-和7-环位置可连接的一个或多个基团; 其中每个X和T独立地选自氢，卤素，烷基，环烷基，环烷基烷基，卤代烷基，烯基，炔基，苯基，苄基，羟基，羟基烷基，烷氧基，苯氧基，烷氧基烷基，苄氧基，氰基，烷酰基，烷硫基，芳硫基和氨基 ; 或其药学上可接受的盐。

8. 发明授权

US5385895A Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury 失效
标题翻译：可用于减少神经毒性损伤的膦酰基 - 异喹啉化合物
公开(公告)号：US5385895A
公开(公告)日：1995-01-31
申请号：US956813
申请日：1992-10-05
申请人： Alexis A. Cordi , Michael L. Vazquez
发明人： Alexis A. Cordi , Michael L. Vazquez
IPC分类号： C07F9/40 , C07F9/62 , C07F9/60 , A61K31/675
CPC分类号： C07F9/4021 , C07F9/62
摘要： A class of phosphono-hydroisoquinoline compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phosphono-hydroisoquinoline compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1 through R.sup.4 is hydrido, each of Z.sup.1 and Z.sup.2 is hydroxyl and wherein the A ring is saturated.
摘要翻译：描述了一类膦酰基 - 氢异喹啉化合物用于治疗以减少与缺氧或局部缺血相关的神经毒性损伤，其通常在中风，心脏骤停或围产期窒息之后。该治疗包括单独施用膦酰基 - 氢异喹啉化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中R 1至R 4各自为氢，Z 1和Z 2各自为羟基，并且其中A环为饱和的。

9. 发明授权

US4562205A Derivatives of 2-aminoacetic acid 失效
标题翻译： 2-氨基乙酸的衍生物
公开(公告)号：US4562205A
公开(公告)日：1985-12-31
申请号：US624110
申请日：1984-06-25
申请人： Robert G. Cavalier , Alexis A. Cordi , Claude L. Gillet , Philippe M. Janssens de Varebeke , Paul J. Niebes , Joseph L. Roba , William R. Van Dorsser , Georges E. Lambelin , Michel R. Franz
发明人： Robert G. Cavalier , Alexis A. Cordi , Claude L. Gillet , Philippe M. Janssens de Varebeke , Paul J. Niebes , Joseph L. Roba , William R. Van Dorsser , Georges E. Lambelin , Michel R. Franz
IPC分类号： A61K31/195 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , C07C233/47
CPC分类号： C07C233/47
摘要： 2-Pentanoylaminoacetic acid and pharmaceutically suitable salts thereof are claimed for use as pharmaceuticals.The compounds are useful in producing an effect on the central nervous system, especially in the treatment of various forms of epilepsy, of disninesiae, of parkinsonism, of memory troubles, of psychic troubles and of cerebral anoxia.
摘要翻译： 2-戊酰氨基乙酸及其药学上合适的盐被要求用作药物。这些化合物可用于产生对中枢神经系统的作用，特别是治疗各种形式的癫痫症，麻痹症，帕金森综合征，记忆障碍，心理障碍和脑缺氧的作用。

10. 发明授权

US5480876A Phosphonomethyl-imidazo[1,2-A]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury 失效
标题翻译：用于治疗神经毒性损伤的膦酰基甲基 - 咪唑并[1,2-A]嘧啶-2-羧酸化合物
公开(公告)号：US5480876A
公开(公告)日：1996-01-02
申请号：US212618
申请日：1994-03-14
申请人： Alexis A. Cordi , Eric T. Sun
发明人： Alexis A. Cordi , Eric T. Sun
IPC分类号： C07F9/6561 , A61K31/505 , C07F9/09
CPC分类号： C07F9/6561
摘要： A class of phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest, hypoglycemia or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.6 is independently selected from hydrido, alkyl, allyl, cycloalkyl, cycloalkylalkyl, phenyl and benzyl; wherein Y.sub.m is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --; where m is one; wherein X is one or more groups attachable at one or more of the 5-, 6- and 7-ring positions of the imidazo[1,2-a]pyrimidine ring system; wherein each x and T is independently selected from hydrido, halo, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, alkenyl, alkynyl, phenyl, benzyl, hydroxy, hydroxyalkyl, alkoxy, phenoxy, alkoxyalkyl, benzyloxy, cyano, alkanoyl, alkylthio, arylthio and amino; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类膦酰基甲基 - 咪唑并[1,2-a]嘧啶-2-羧酸化合物用于治疗，以减少与缺氧或缺血相关的神经毒性损伤，其通常在中风，心脏骤停，低血糖或围产期窒息之后。治疗包括单独施用该类化合物或以有效作为拮抗剂的量的组合物施用以抑制主要神经元兴奋性氨基酸受体位点的兴奋性毒性作用。最感兴趣的化合物是下式的化合物：其中R 1，R 2和R 6各自独立地选自氢，烷基，烯丙基，环烷基，环烷基烷基，苯基和苄基; 其中Ym是-CH 2 - 或-CH 2 -CH 2 - ; 哪里是一个; 其中X是在咪唑并[1,2-a]嘧啶环体系的一个或多个5-，6-和7-环位置可连接的一个或多个基团; 其中每个x和T独立地选自氢，卤素，烷基，环烷基，环烷基烷基，卤代烷基，烯基，炔基，苯基，苄基，羟基，羟烷基，烷氧基，苯氧基，烷氧基烷基，苄氧基，氰基，烷酰基，烷硫基，芳硫基和氨基 ; 或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式