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1. 发明授权

US08460880B2 Compositions, splice variants and methods relating to ovarian specific genes and proteins 有权
公开(公告)号：US08460880B2
公开(公告)日：2013-06-11
申请号：US12383449
申请日：2009-03-24
申请人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
IPC分类号： G01N33/53
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

2. 发明申请

US20090263411A1 Compositions, splice variants and methods relating to ovarian specific genes and proteins 有权
标题翻译：与卵巢特异性基因和蛋白质有关的组合物，剪接变体和方法
公开(公告)号：US20090263411A1
公开(公告)日：2009-10-22
申请号：US12383449
申请日：2009-03-24
申请人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
IPC分类号： A61K39/00 , C12N15/11 , C12Q1/68 , C12N15/00 , C12N1/21 , C12P21/02 , C07K14/00 , C07K16/18
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

3. 发明授权

US06902890B1 Method of diagnosing monitoring, staging, imaging and treating cancer 失效
标题翻译：诊断监测，分期，成像和治疗癌症的方法
公开(公告)号：US06902890B1
公开(公告)日：2005-06-07
申请号：US09705500
申请日：2000-11-03
申请人： Herve Recipon , Roberto A. Macina , Sei-Yu Chen , Yongming Sun
发明人： Herve Recipon , Roberto A. Macina , Sei-Yu Chen , Yongming Sun
IPC分类号： A61K39/00 , A61K49/16 , A61K51/10 , C07K16/30 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57423 , A61K39/0011 , A61K49/16 , A61K51/1054 , A61K2039/505 , C07K16/3023 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/574
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗癌症的新方法。

4. 发明授权

US06858386B1 Method of diagnosing, monitoring, staging, imaging and treating colon cancer 有权
公开(公告)号：US06858386B1
公开(公告)日：2005-02-22
申请号：US09618596
申请日：2000-07-17
申请人： Roberto A. Macina , Yongming Sun
发明人： Roberto A. Macina , Yongming Sun
IPC分类号： A61K39/00 , A61K51/10 , C07K16/18 , C07K16/30 , C12Q1/68 , G01N33/574 , C12Q1/00 , G01N33/53 , G01N33/567
CPC分类号： C07K16/18 , A61K39/0011 , A61K51/1063 , A61K2039/505 , C07K16/3046 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57419 , Y10T436/25
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating colon cancer.

5. 发明授权

US07326402B2 Method of diagnosing, monitoring, staging, imaging and treating cancer 失效
标题翻译：诊断，监测，分期，成像和治疗癌症的方法
公开(公告)号：US07326402B2
公开(公告)日：2008-02-05
申请号：US11068678
申请日：2005-02-28
申请人： Herve Recipon , Roberto A. Macina , Sei-Yu Chen , Yongming Sun
发明人： Herve Recipon , Roberto A. Macina , Sei-Yu Chen , Yongming Sun
IPC分类号： C12Q1/00 , G01N33/53 , A61K51/10 , A61B5/055
CPC分类号： G01N33/57423 , A61K39/0011 , A61K49/16 , A61K51/1054 , A61K2039/505 , C07K16/3023 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/574
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗癌症的新方法。

6. 发明授权

US06869592B1 Method and antibody for imaging lung cancer 失效
标题翻译：肺癌成像方法及抗体
公开(公告)号：US06869592B1
公开(公告)日：2005-03-22
申请号：US09762028
申请日：1999-07-19
申请人： Fei Yang , Yongming Sun , Herve Recipon , Roberto A. Macina
发明人： Fei Yang , Yongming Sun , Herve Recipon , Roberto A. Macina
IPC分类号： A61K39/00 , A61K49/16 , A61K51/10 , C07K14/47 , G01N33/574 , A61K49/00 , A61K39/395 , C12P21/08 , G01N33/53
CPC分类号： C07K14/4748 , A61K39/00 , A61K49/16 , A61K51/1093 , G01N33/57423 , G01N33/57484
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗肺癌的新方法。

7. 发明授权

US07678889B2 Compositions and methods relating to ovarian specific genes and proteins 失效
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US07678889B2
公开(公告)日：2010-03-16
申请号：US10523834
申请日：2003-08-06
申请人： Roberto A. Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah R. Turner
发明人： Roberto A. Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah R. Turner
IPC分类号： C07K16/00
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

8. 发明申请

US20080267863A1 Method of Diagnosing, Monitoring, Staging, Imaging and Treating Colon Cancer 审中-公开
标题翻译：诊断，监测，分期，成像和治疗结肠癌的方法
公开(公告)号：US20080267863A1
公开(公告)日：2008-10-30
申请号：US12136444
申请日：2008-06-10
申请人： Roberto A. Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve E. Recipon
发明人： Roberto A. Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve E. Recipon
IPC分类号： A61K51/10 , C07H21/04 , C07K14/705 , C12Q1/68 , A61P35/04 , A61K39/00 , C07K16/18 , A61K39/395
CPC分类号： G01N33/57419 , A61K49/0008 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating colon cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗结肠癌的新方法。

9. 发明授权

US07160679B1 Method of diagnosing, monitoring, and staging lung cancer 失效
标题翻译：诊断，监测和分期肺癌的方法
公开(公告)号：US07160679B1
公开(公告)日：2007-01-09
申请号：US09700770
申请日：1999-05-12
申请人： Fei Yang , Roberto A. Macina , Yongming Sun
发明人： Fei Yang , Roberto A. Macina , Yongming Sun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating lung cancer.
摘要翻译：本发明提供了一种检测，诊断，监测，分期和预后肺癌的新方法。

10. 发明授权

US06949339B1 Method of diagnosing, monitoring, and staging colon cancer 失效
标题翻译：诊断，监测和分期结肠癌的方法
公开(公告)号：US06949339B1
公开(公告)日：2005-09-27
申请号：US09700769
申请日：1999-05-12
申请人： Roberto A. Macina , Fei Yang , Yongming Sun
发明人： Roberto A. Macina , Fei Yang , Yongming Sun
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating colon cancer.
摘要翻译：本发明提供了一种检测，诊断，监测，分期和预后结肠癌的新方法。

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