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    • 7. 发明授权
    • Compositions and methods relating to ovarian specific genes and proteins
    • 与卵巢特异性基因和蛋白质有关的组成和方法
    • US07678889B2
    • 2010-03-16
    • US10523834
    • 2003-08-06
    • Roberto A. MacinaSusana SalcedaChenghua LiuYongming SunLeah R. Turner
    • Roberto A. MacinaSusana SalcedaChenghua LiuYongming SunLeah R. Turner
    • C07K16/00
    • C07K14/82A61K38/00A61K39/00C07K14/47
    • The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
    • 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽,包括核酸和多肽的片段,变体和衍生物。 本发明还涉及本发明多肽的抗体,以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子,多肽,抗体,激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在卵巢中识别,诊断,监测,分期,成像和治疗卵巢癌和非癌性疾病状态,鉴定卵巢组织,监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗,转基因动物和细胞的生产,以及用于治疗和研究的工程化卵巢组织的生产。