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1. 发明申请

US20060128641A1 Levamisole, avermectins or similar in pyrrolidone solvent 审中-公开
标题翻译：吡咯烷酮溶剂中的左旋咪唑，除虫菌素或类似物
公开(公告)号：US20060128641A1
公开(公告)日：2006-06-15
申请号：US10521604
申请日：2003-07-21
申请人： Robert William Holmes , Majid Razzak , Sen Nilendu , Kour Jindal
发明人： Robert William Holmes , Majid Razzak , Sen Nilendu , Kour Jindal
IPC分类号： A61K31/7048 , A01N43/04
CPC分类号： A61K9/0019 , A61K9/0014 , A61K31/365 , A61K31/429 , A61K47/22
摘要： A stable formulation which is suitable for administration to animals is claimed. The formulation includes at least one active selected from the group comprising avermectins and milbemycins and levamisole. Both of the actives are dissolved in a pyrrolidone solvent.
摘要翻译：要求保护适用于动物给药的稳定制剂。该制剂包含至少一种选自阿维菌素和米尔倍霉素和左旋咪唑的活性物质。两种活性物质都溶于吡咯烷酮溶剂中。

2. 发明申请

US20070219175A1 Controlled Release Pharmaceutical Composition Comprising An Acid-Insoluble And A Bioadhesive Polymer 审中-公开
标题翻译：包含酸不溶性和生物粘合聚合物的控制释放药物组合物
公开(公告)号：US20070219175A1
公开(公告)日：2007-09-20
申请号：US10551058
申请日：2005-01-05
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/43
CPC分类号： A61K9/2095 , A61K9/1635 , A61K9/2081 , A61K9/5026 , A61K9/5036 , A61K9/5042 , A61K31/43 , A61K45/06 , A61K2300/00
摘要： Rapidly disintegrating oral controlled release pharmaceutical compositions and process for preparation of such compositions are provided. The compositions preferably comprise antibiotic(s) as active ingredient, more preferably amoxicillin either alone or in combination with other antibiotic(s). The controlled release compositions comprise at least one active ingredient, and a polymer system comprising of at least two polymers which retard the release of the active ingredient in the stomach while providing rapid release of the said active ingredient in the alkaline contents of small intestine, optionally with other pharmaceutically acceptable excipients. The compositions provide therapeutically effective levels of the active ingredient for extended periods of time, and possess bioadhesive properties.
摘要翻译：提供快速崩解的口服释药药物组合物和制备这些组合物的方法。组合物优选包含抗生素作为活性成分，更优选单独或与其它抗生素组合使用阿莫西林。控释组合物包含至少一种活性成分和包含至少两种聚合物的聚合物体系，所述聚合物延缓了胃中活性成分的释放，同时提供所述活性成分在小肠的碱性成分中的快速释放，任选地与其它药学上可接受的赋形剂。该组合物延长时间段提供治疗有效水平的活性成分，并且具有生物粘合性质。

3. 发明申请

US20070160664A1 Pharmaceutical compositions comprising of proton pump inhibitor and prokinetic agent 审中-公开
标题翻译：包含质子泵抑制剂和促动力剂的药物组合物
公开(公告)号：US20070160664A1
公开(公告)日：2007-07-12
申请号：US11482186
申请日：2006-07-06
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/4439 , A61K9/64 , A61K9/24
CPC分类号： A61K31/4439 , A61K9/2081 , A61K9/209 , A61K9/4808 , A61K9/5078 , A61K31/136 , A61K31/138
摘要： Oral pharmaceutical compositions and process for preparation thereof are provided comprising at least one gastric acid suppressing agent, preferably a proton pump inhibitor or its pharmaceutically acceptable salts, esters, hydrates, derivatives or prodrugs, and one or more prokinetic agent or its pharmaceutically acceptable salts, esters, hydrates, derivatives or prodrugs, optionally with other pharmaceutically acceptable excipients, characterized in that the gastric acid suppressing agent is present in a delayed release form and the prokinetic agent is present in a bimodal release form such as an immediate release form to provide an initial loading dose, and a delayed release form to provide a dose with a lag time; with the proviso that the prokinetic agent is not formulated using a hydrophilic rate controlling polymer and is not present in a sustained release form. Method of treatment of gastro esophageal reflux disease, reflux esophagitis, peptic ulcer, gastric ulcer, and other gastric acid related disorders by administering to a patient such a pharmaceutical composition in need thereof is also provided.
摘要翻译：提供了口服药物组合物及其制备方法，其包含至少一种胃酸抑制剂，优选质子泵抑制剂或其药学上可接受的盐，酯，水合物，衍生物或前药，以及一种或多种促动力剂或其药学上可接受的盐，酯，水合物，衍生物或前药，任选地与其它药学上可接受的赋形剂，其特征在于所述胃酸抑制剂以延迟释放形式存在，并且促动力剂以双峰释放形式存在，例如立即释放形式，以提供初始加载剂量和延迟释放形式以提供具有滞后时间的剂量; 条件是促动剂不是使用亲水性速率控制聚合物配制的，并且不以缓释形式存在。还提供了通过向患者施用这种有此需要的药物组合物来治疗胃食管反流病，反流性食管炎，消化性溃疡，胃溃疡和其它胃酸相关疾病的方法。

4. 发明申请

US20070128276A1 Controlled release compositions comprising nimesulide 审中-公开
标题翻译：含有尼美舒利的控制释放组合物
公开(公告)号：US20070128276A1
公开(公告)日：2007-06-07
申请号：US11545718
申请日：2006-10-10
申请人： Rajesh Jain , Kour Jindal , Munish Talwar
发明人： Rajesh Jain , Kour Jindal , Munish Talwar
IPC分类号： A61K9/22 , A61K31/165
CPC分类号： A61K9/4891 , A61K9/0004 , A61K9/2054 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K9/5078 , A61K9/5084 , A61K31/18
摘要： A controlled release composition comprising nimesulide as an active agent formulated as a gastroretentive system, preferably as a solid oral dosage form is provided, wherein the residence time of the active agent is increased in the stomach, duodenum, jejunum or ileum. The present invention also provides process of preparing such dosage form and methods of using such dosage form compositions. The dosage form compositions are preferably administered once-a-day or twice-a-day and are particularly very useful in the prophylaxis or treatment of NSAID indicated disorder(s) such as acute painful conditions like post-operative trauma, pain associated with cancer, sports injuries, migraine headache and the like, or chronic diseases such as arthritis and the like.
摘要翻译：提供了包含尼美舒利作为配制为胃滞留系统的活性剂，优选为固体口服剂型的控释组合物，其中活性剂在胃，十二指肠，空肠或回肠中的停留时间增加。本发明还提供了制备这种剂型的方法和使用这种剂型组合物的方法。剂型组合物优选每天一次或每天两次施用，并且特别非常有用于预防或治疗NSAID指示的病症，例如急性疼痛病症如手术后创伤，与癌症相关的疼痛，运动损伤，偏头痛等，或诸如关节炎等慢性疾病。

5. 发明申请

US20070027218A1 Pharmaceutical compositions comprising higher primary alcohols and ezetimibe and process of preparation thereof 审中-公开
标题翻译：包含高级伯醇和依泽替米贝的药物组合物及其制备方法
公开(公告)号：US20070027218A1
公开(公告)日：2007-02-01
申请号：US11489253
申请日：2006-07-19
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/045 , A61K47/00
CPC分类号： A61K31/045 , A61K31/397 , A61K2300/00
摘要： A novel pharmaceutical composition comprising a mixture of higher primary aliphatic alcohols from 24 to 39 carbon atoms; at least one another component selected from resins and pigments, hydrocarbons, esters, ketones and aldehydes, and phenolic compounds, and ezetimibe, its salts, analogs or derivatives thereof optionally with pharmaceutically acceptable excipients, and process of preparation of such composition is provided. Also provided are method of treatment and use of such composition for reducing abnormal lipid parameters associated with hyperlipidemia.
摘要翻译：一种新型药物组合物，其包含来自24至39个碳原子的高级伯脂肪醇的混合物; 提供了选自树脂和颜料，烃，酯，酮和醛以及酚类化合物中的至少一种组分，以及任选具有药学上可接受的赋形剂的依泽替米贝，其盐，类似物或衍生物，以及制备该组合物的方法。还提供了治疗和使用这种组合物以减少与高脂血症相关的异常脂质参数的方法。

6. 发明申请

US20070027195A1 Novel compositions comprising higher primary alcohols and nicottinic acid and process of preparation thereof 审中-公开
标题翻译：包含高级伯醇和烟酸的新型组合物及其制备方法
公开(公告)号：US20070027195A1
公开(公告)日：2007-02-01
申请号：US11489254
申请日：2006-07-19
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/455 , A61K31/045 , A61K47/00
CPC分类号： A61K31/045 , A61K31/455 , A61K2300/00
摘要： A composition comprising a mixture of higher primary aliphatic alcohols from 24 to 39 carbon atoms; at least one another component selected from resins and pigments, hydrocarbons, esters, ketones and aldehydes, and phenolic compounds, and nicotinic acid, its salts or derivatives thereof optionally with excipients, and process of preparation of such composition is provided. Also provided are method of treatment and use of such composition for reducing abnormal lipid parameters associated with hyperlipidemia. The compositions of the present invention are useful pharmaceutically or as a dietary supplement.
摘要翻译：一种组合物，其包含来自24至39个碳原子的高级伯脂肪醇的混合物; 提供了选自树脂和颜料，烃，酯，酮和醛以及酚类化合物中的至少一种组分，以及任选地与赋形剂的烟酸，其盐或衍生物，以及制备该组合物的方法。还提供了治疗和使用这种组合物以减少与高脂血症相关的异常脂质参数的方法。本发明的组合物在药学上或作为膳食补充剂是有用的。

7. 发明申请

US20060198905A1 Pharmaceutical compositions comprising an extract of euphorbia prostrata 有权
标题翻译：包含大戟提取物的药物组合物
公开(公告)号：US20060198905A1
公开(公告)日：2006-09-07
申请号：US10551797
申请日：2004-12-31
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh , Aniruddha Datta
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh , Aniruddha Datta
IPC分类号： A61K36/81 , A61K36/47
CPC分类号： A61K36/47 , A61K36/185 , A61K36/48 , A61K2300/00
摘要： The invention relates to novel compositions comprising of an extract of the plant Euphorbia prostrata, particularly with pharmaceutically acceptable carrier(s)/base(s), optionally with additional therapeutic agent(s) useful for the treatment of anorectal disease and colonic diseases such as hemorrhoids, fissures, cracks, fistulas, abscesses, inflammatory bowel disease, and the like. The nove( compositions possess properties to contro( inflammation, prevent capillary bleeding and fragility in mammalians, particularly human beings. Process for the preparation of such novel compositions comprising an extract of the plant Euphorbia prostrata and pharmaceutically acceptable carrier(s)/base(s) useful for the treatment of anorectal disease including hemorrhoids, and colonic diseases are also provided. The composition comprise of flavonoidal and phenolic constituents extracted from the plant Euphorbia prostrata that possess anti-inflammatory, analgesic, haemostatic and wound-healing properties.
摘要翻译：本发明涉及包含植物大戟提取物，特别是与药学上可接受的载体/碱的提取物的新型组合物，任选地可用于治疗肛门直肠疾病和结肠疾病的其它治疗剂，例如痔疮，裂缝，裂缝，瘘，脓肿，炎症性肠病等。 nove（组合物具有控制性质（炎症，预防毛发血管渗透和哺乳动物，特别是人类的脆性）。制备这种新型组合物的方法，其包含植物大戟提取物和药学上可接受的载体/碱）可用于治疗包括痔疮在内的肛门直肠疾病和结肠疾病，该组合物包含从具有抗炎，镇痛，止血和伤口愈合特性的植物大戟科提取的黄酮和酚成分。

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