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1. 发明授权

US06787519B2 Methods of treating disorders related to apoE 失效
公开(公告)号：US06787519B2
公开(公告)日：2004-09-07
申请号：US10033526
申请日：2001-11-02
申请人： Yadong Huang , Robert W. Mahley
发明人： Yadong Huang , Robert W. Mahley
IPC分类号： A61K3800
CPC分类号： C07K5/1008 , A01K2217/05 , A61K38/00 , C07K14/775
摘要： The present invention provides methods inhibiting formation of neurofibrillary tangles; and methods for treating disorders relating to apolipoprotein E (apoE) in a subject. The methods generally involve reducing the level of a carboxyl-terminal truncated form of apoE in a neuronal cell of a subject. The invention further provides isolated cells comprising a nucleic acid molecule encoding a carboxyl-terminal truncated form of apoE; and methods of screening compounds using the cells. The invention further provides compounds that inhibit an apoE cleavage enzyme, and that reduce the formation of neurofibrillary tangles in a neuronal cell. The invention further provides transgenic non-human animals that include as a transgene a nucleic acid that encodes a carboxyl-terminal truncated form of apoE; as well as methods of screening compounds using transgenic animals.

2. 发明申请

US20090136456A1 METHODS OF TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：治疗神经损伤性疾病的方法
公开(公告)号：US20090136456A1
公开(公告)日：2009-05-28
申请号：US11961951
申请日：2007-12-20
申请人： Yadong Huang , Gang Li , Robert W. Mahley , Qin Xu
发明人： Yadong Huang , Gang Li , Robert W. Mahley , Qin Xu
IPC分类号： A61K35/12 , C12N5/00 , A61P25/28
CPC分类号： C12N5/0623 , A61K35/12 , C12N2501/115 , C12N2510/00
摘要： The present invention provides a selected population of neural cells, including neural stem cells, neural progenitor cells, neural precursor cells, and progeny thereof, which neural cells are selected for an apoE4− phenotype. In some embodiments, the neural cells are further selected for an apoE3+ phenotype. The selected population of neural cells is useful in treating various disorders, such as neurodegenerative disorders and demyelination diseases. The present invention further provides methods of treating neurodegenerative disorders and demyelinating diseases, generally involving administering a subject selected cell population.
摘要翻译：本发明提供了选择的神经细胞群，包括神经干细胞，神经祖细胞，神经前体细胞及其后代，其选择了用于apoE4表型的神经细胞。在一些实施方案中，进一步选择神经细胞用于apoE3 +表型。所选择的神经细胞群可用于治疗各种疾病，例如神经变性疾病和脱髓鞘疾病。本发明进一步提供治疗神经变性疾病和脱髓鞘疾病的方法，通常涉及给予受试者所选择的细胞群体。

3. 发明申请

US20090082271A1 AGENTS THAT REDUCE APOE-INDUCED IMPAIRMENT OF MITOCHONDRIA AND METHODS OF USE THEREOF 审中-公开
标题翻译：减少麻醉药引起的APOE诱导的损伤的药剂及其使用方法
公开(公告)号：US20090082271A1
公开(公告)日：2009-03-26
申请号：US12092550
申请日：2006-12-07
申请人： Robert W. Mahley , Yadong Huang
发明人： Robert W. Mahley , Yadong Huang
IPC分类号： A61K38/16 , A61P25/00
CPC分类号： A61K38/1709
摘要： The present invention provides isolated cells comprising a nucleic acid encoding a toxic form of apoE. The present invention further provides screening methods for identifying compounds that reduce apoE-induced impairment of mitochondrial integrity and/or function. The present invention further provides kits for use in carrying out a subject screening method. The present invention provides agents that reduce apoE-induced impairment of mitochondrial integrity and/or function; and use of such agents in the treatment of apoE-related disorders.
摘要翻译：本发明提供了分离的细胞，其包含编码毒性形式的apoE的核酸。本发明还提供用于鉴定减少apoE诱导的线粒体完整性和/或功能损伤的化合物的筛选方法。本发明还提供了用于进行受试者筛选方法的试剂盒。本发明提供减少apoE诱导的线粒体完整性和/或功能损伤的药剂; 以及这些药物在治疗apoE相关疾病中的用途。

4. 发明申请

US20120129782A1 Inhibition of ApoE Cleavage Activity in the Treatment of ApoE-Related Disorders 审中-公开
标题翻译： ApoE切除活性抑制ApoE相关疾病的治疗
公开(公告)号：US20120129782A1
公开(公告)日：2012-05-24
申请号：US13130003
申请日：2009-11-20
申请人： Yadong Huang , Qin Xu , Mei Xiu Steele , Robert W. Mahley , Karl H. Weisgraber , Stephen Barry Freedman
发明人： Yadong Huang , Qin Xu , Mei Xiu Steele , Robert W. Mahley , Karl H. Weisgraber , Stephen Barry Freedman
IPC分类号： A61K38/02 , C12Q1/37 , A61P25/28 , A61K31/713 , A61P29/00
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C07K14/775 , C12N2310/14 , C12N2310/531 , C12Y304/21092 , G01N33/92 , G01N2333/96433 , G01N2500/02 , G01N2800/2821 , A61K2300/00
摘要： The present invention provides methods for treating apoE-related disorders. The methods generally involve administering an effective amount of an agent that inhibits activity of an enzyme that cleaves apoE.
摘要翻译：本发明提供了治疗apoE相关疾病的方法。所述方法通常涉及施用有效量的抑制切割apoE的酶活性的试剂。

5. 发明授权

US07964598B2 ApoE4 domain interaction inhibitors and methods of use thereof 有权
标题翻译： ApoE4结构域相互作用抑制剂及其使用方法
公开(公告)号：US07964598B2
公开(公告)日：2011-06-21
申请号：US11244268
申请日：2005-10-04
申请人： Robert W. Mahley , Karl H. Weisgraber , Yadong Huang
发明人： Robert W. Mahley , Karl H. Weisgraber , Yadong Huang
IPC分类号： A61K31/535 , A61K31/42 , A61K31/38 , A01N43/76 , A01N43/12 , C07D498/00 , C07D487/00
CPC分类号： A61K31/185 , A61K31/381 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K31/655
摘要： The present invention provides compounds that inhibit apoE4 domain interaction; and compositions, including pharmaceutical compositions, comprising the compounds. The present invention provides methods of treating apoE4-related disorders. The methods generally involve administering to an individual in need thereof a therapeutically effective amount of an apoE4 domain interaction inhibitor.
摘要翻译：本发明提供抑制apoE4结构域相互作用的化合物; 和包含该化合物的组合物，包括药物组合物。本发明提供了治疗apoE4相关疾病的方法。所述方法通常涉及向有需要的个体施用治疗有效量的apoE4结构域相互作用抑制剂。

6. 发明授权

US07700304B2 Methods of screening disorders related to apoE 有权
标题翻译：筛查与apoE相关的疾病的方法
公开(公告)号：US07700304B2
公开(公告)日：2010-04-20
申请号：US10820618
申请日：2004-04-07
申请人： Yadong Huang , Robert W. Mahley
发明人： Yadong Huang , Robert W. Mahley
IPC分类号： G01N33/53
CPC分类号： C07K5/1008 , A01K2217/05 , A61K38/00 , C07K14/775
摘要： The present invention provides methods inhibiting formation of neurofibrillary tangles; and methods for treating disorders relating to apolipoprotein E (apoE) in a subject. The methods generally involve reducing the level of a carboxyl-terminal truncated form of apoE in a neuronal cell of a subject. The invention further provides isolated cells comprising a nucleic acid molecule encoding a carboxyl-terminal truncated form of apoE; and methods of screening compounds using the cells. The invention further provides compounds that inhibit an apoE cleavage enzyme, and that reduce the formation of neurofibrillary tangles in a neuronal cell. The invention further provides transgenic non-human animals that include as a transgene a nucleic acid that encodes a carboxyl-terminal truncated form of apoE; as well as methods of screening compounds using transgenic animals.
摘要翻译：本发明提供抑制神经原纤维缠结形成的方法; 以及用于治疗受试者中与载脂蛋白E（apoE）相关的疾病的方法。所述方法通常涉及降低受试者的神经元细胞中apoE的羧基末端截短形式的水平。本发明还提供了包含编码apoE的羧基末端截短形式的核酸分子的分离的细胞; 以及使用细胞筛选化合物的方法。本发明还提供抑制apoE切割酶并减少神经元细胞中神经原纤维缠结的形成的化合物。本发明还提供了转基因非人动物，其包含编码apoE的羧基末端截短形式的核酸作为转基因; 以及使用转基因动物筛选化合物的方法。

7. 发明申请

US20070178535A1 Methods of identifying agents that modulate mitochondrial function 有权
标题翻译：鉴定调节线粒体功能的药物的方法
公开(公告)号：US20070178535A1
公开(公告)日：2007-08-02
申请号：US11636110
申请日：2006-12-07
申请人： Yadong Huang , Jens Brodbeck
发明人： Yadong Huang , Jens Brodbeck
IPC分类号： G01N33/567 , C12N5/08 , C12N5/06
CPC分类号： G01N33/5079 , G01N33/92 , G01N2333/775
摘要： The present invention provides isolated cells comprising a nucleic acid encoding a toxic form of apoE. The present invention further provides screening methods for identifying compounds that reduce apoE-induced impairment of mitochondrial integrity and/or function. The present invention further provides kits for use in carrying out a subject screening method. The present invention provides agents that reduce apoE-induced impairment of mitochondrial integrity and/or function; and use of such agents in the treatment of apoE-related disorders.
摘要翻译：本发明提供了分离的细胞，其包含编码毒性形式的apoE的核酸。本发明还提供用于鉴定减少apoE诱导的线粒体完整性和/或功能损伤的化合物的筛选方法。本发明还提供了用于进行受试者筛选方法的试剂盒。本发明提供减少apoE诱导的线粒体完整性和/或功能损伤的药剂; 以及这些药物在治疗apoE相关疾病中的用途。

8. 发明申请

US20130017251A1 Antibody Specific for Apolipoprotein and Methods of Use Thereof 有权
标题翻译：载体蛋白特异性抗体及其使用方法
公开(公告)号：US20130017251A1
公开(公告)日：2013-01-17
申请号：US13581785
申请日：2011-02-25
申请人： Yadong Huang , Qin Xu , Thu Nga Bien-Ly , Karl H. Weisgraber , Ligong Chen , Clare Peters-Libeu
发明人： Yadong Huang , Qin Xu , Thu Nga Bien-Ly , Karl H. Weisgraber , Ligong Chen , Clare Peters-Libeu
IPC分类号： C07K16/18 , C07K17/08 , C12N15/63 , C07K17/10 , A61K9/127 , A61P25/00 , G01N33/566 , C07K17/02 , C07K16/46 , A61K39/395
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/76
摘要： The present disclosure provides synthetic antibodies specific for an epitope present on an apolipoprotein E polypeptide. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
摘要翻译：本公开提供对存在于载脂蛋白E多肽上的表位特异性的合成抗体。抗体可用于各种治疗，诊断和监测应用，这些也被提供。

9. 发明申请

US20090011415A1 REGULATION OF NEURONAL EXPRESSION OF APOLIPOPROTEIN E 有权
标题翻译： APOLIPOPROTEIN神经表达调控E
公开(公告)号：US20090011415A1
公开(公告)日：2009-01-08
申请号：US11960229
申请日：2007-12-19
申请人： Yadong Huang , Qin Xu
发明人： Yadong Huang , Qin Xu
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/00 , C12N1/20 , C12Q1/02
CPC分类号： C07K14/775 , C12Q1/6883 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/5058 , G01N2333/775
摘要： The present invention provides nucleic acids comprising a nucleotide sequence encoding an apolipoprotein E (apoE) splice variant, e.g., an unprocessed apoE, that retains intron 3; and vectors and host cells comprising same. The present invention further provides screening methods to identify agents that inhibit cleavage of intron-3 from the apoE splice variant. The present invention further provides methods of treating apoE-related neurological disorders, involving administering an agent that inhibits removal of intron-3 from a precursor apoE mRNA.
摘要翻译：本发明提供核酸，其包含编码保留内含子3的载脂蛋白E（apoE）剪接变体（例如未加工的apoE）的核苷酸序列; 以及包含其的载体和宿主细胞。本发明还提供了鉴定抑制内含子-3从apoE剪接变体切割的试剂的筛选方法。本发明还提供了治疗apoE相关神经系统疾病的方法，包括施用抑制内含子-3从前体apoE mRNA去除的药剂。

10. 发明授权

US09102717B2 Antibody specific for apolipoprotein and methods of use thereof 有权
标题翻译：对载脂蛋白特异的抗体及其使用方法
公开(公告)号：US09102717B2
公开(公告)日：2015-08-11
申请号：US13581785
申请日：2011-02-25
申请人： Yadong Huang , Qin Xu , Thu Nga Bien-Ly , Karl H. Weisgraber , Ligong Chen , Clare Peters-Libeu
发明人： Yadong Huang , Qin Xu , Thu Nga Bien-Ly , Karl H. Weisgraber , Ligong Chen , Clare Peters-Libeu
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/76
摘要： The present disclosure provides synthetic antibodies specific for an epitope present on an apolipoprotein E polypeptide. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
摘要翻译：本公开提供对存在于载脂蛋白E多肽上的表位特异性的合成抗体。抗体可用于各种治疗，诊断和监测应用，这些也被提供。

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